GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16923147
| Citation |
Fernandes, C, Hoyle, E, Dempster, E, Schalkwyk, LC and Collier, DA (2006) Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 5:433-40 |
|---|---|
| Abstract |
Patients with schizophrenia exhibit deficits in a range of cognitive functions, particularly working and episodic memory, which are thought to be core features of the disorder. Memory dysfunction in schizophrenia is familial and thus a promising endophenotype for genetic studies. Both human and animal studies suggest a role for the neural nicotinic acid receptor family in cognition and specifically the alpha7-receptor subunit in schizophrenia and its endophenotypes. Consequently, we tested mice lacking the alpha7 subunit of the neural nicotinic receptor (B6.129S7-Chrna7(tm1Bay)/J) in the delayed matching-to-place (DMP) task of the Morris water maze, a measure of working/episodic memory akin to human episodic memory. We report that a minor impairment in alpha7 knockout mice was observed in the DMP task, with knockout mice taking longer to find the hidden platform than their wildtype controls. This suggests a role for the alpha7 subunit in working/episodic memory and a potential role for the alpha7 neural nicotinic receptor gene (CHRNA7) in schizophrenia and its endophenotypes. |
| Links |
PubMed Online version:10.1111/j.1601-183X.2005.00176.x |
| Keywords |
Acetylcholine/metabolism; Animals; Brain/metabolism; Brain/physiopathology; Disease Models, Animal; Learning Disorders/genetics; Learning Disorders/metabolism; Learning Disorders/physiopathology; Male; Maze Learning/physiology; Memory Disorders/genetics; Memory Disorders/metabolism; Memory Disorders/physiopathology; Memory, Short-Term/physiology; Mice; Mice, Knockout; Neuropsychological Tests; Psychomotor Performance/physiology; Receptors, Nicotinic/genetics; Schizophrenia/genetics; Schizophrenia/metabolism; Schizophrenia/physiopathology; Schizophrenic Psychology; Synaptic Transmission/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
