MOUSE:5HT2B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Htr2b
Protein Name(s)	5-hydroxytryptamine receptor 2B 5-HT-2B 5-HT2B 5-HT-2F NP75 protein Serotonin receptor 2B
External Links
UniProt	Q02152
EMBL	Z15119 AJ012488 AF498254 AF498255 AK033713 BC023690
CCDS	CCDS35644.1
PIR	S27269
RefSeq	NP_032337.2 XP_006529210.1
UniGene	Mm.439747
ProteinModelPortal	Q02152
SMR	Q02152
ChEMBL	CHEMBL2096671
GuidetoPHARMACOLOGY	7
PhosphoSite	Q02152
PRIDE	Q02152
Ensembl	ENSMUST00000027431
GeneID	15559
KEGG	mmu:15559
UCSC	uc007buz.1
CTD	3357
MGI	MGI:109323
eggNOG	NOG247243
GeneTree	ENSGT00770000120457
HOGENOM	HOG000240378
HOVERGEN	HBG107487
InParanoid	Q02152
KO	K04157
OMA	QYNSRAT
OrthoDB	EOG70ZZN5
TreeFam	TF316350
Reactome	REACT_207651 REACT_232980
NextBio	288504
PRO	PR:Q02152
Proteomes	UP000000589
Bgee	Q02152
CleanEx	MM_HTR2B
ExpressionAtlas	Q02152
Genevestigator	Q02152
GO	GO:0030054 GO:0005737 GO:0005887 GO:0043005 GO:0005886 GO:0045202 GO:0008144 GO:0001965 GO:0005099 GO:0051378 GO:0004993 GO:0007202 GO:0007610 GO:0019722 GO:0003300 GO:0071502 GO:0006182 GO:0048598 GO:0070371 GO:0002031 GO:0007186 GO:0007507 GO:0003007 GO:0014827 GO:0043066 GO:0010507 GO:0060548 GO:0014033 GO:0001755 GO:0014065 GO:0007208 GO:0016310 GO:0051781 GO:0008284 GO:0001819 GO:0050715 GO:0001938 GO:0070374 GO:0043123 GO:0043406 GO:0051000 GO:0010513 GO:0032320 GO:0070528 GO:0007205 GO:0050795 GO:0051209 GO:0042493 GO:0007210 GO:0042310
InterPro	IPR000482 IPR002231 IPR000276 IPR017452
PANTHER	PTHR24247:SF31
Pfam	PF00001
PRINTS	PR00651 PR01101 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008144	drug binding	PMID:16940156^[1]	ECO:0000314			F	Figure 3 and Figure 6 show such activity.	complete CACAO 9337
involved_in	GO:0071502	cellular response to temperature stimulus	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070528	protein kinase C signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:8621713^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:20450948^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	PMID:8621713^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	PMID:21179162^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	PMID:19023134^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048598	embryonic morphogenesis	PMID:9165122^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9165122^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0014827	intestine smooth muscle contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0014033	neural crest cell differentiation	PMID:9165122^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	PMID:17325130^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:8621713^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0003300	cardiac muscle hypertrophy	PMID:19023134^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:9165122^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	PMID:17325130^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:19308295^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:9165122^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0030594	neurotransmitter receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:71034	F	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2342 RGD:2343 RGD:2518 RGD:2522 RGD:2851 RGD:61800 RGD:61801 RGD:620023 RGD:62044 RGD:71034	C	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2830 RGD:2846	P	Seeded From UniProt	complete
involved_in	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2851 RGD:62044	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000037 PANTHER:PTN000664111 RGD:2343 UniProtKB:P08172 UniProtKB:P08908 UniProtKB:P21917 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30546 UniProtKB:P30939 WB:WBGene00001519	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004168 FB:FBgn0004573 FB:FBgn0087012 FB:FBgn0263116 MGI:MGI:109323 MGI:MGI:96273 MGI:MGI:96274 MGI:MGI:96276 MGI:MGI:96281 MGI:MGI:96284 PANTHER:PTN000664111 RGD:2845 RGD:2846 RGD:2848 RGD:2850 RGD:2851 RGD:61800 RGD:62044 RGD:62388 RGD:71034 UniProtKB:A0A0B4KFU6 UniProtKB:P08908 UniProtKB:P28221 UniProtKB:P28222 UniProtKB:P28223 UniProtKB:P28335 UniProtKB:P28566 UniProtKB:P30939 UniProtKB:P41595 UniProtKB:P47898 UniProtKB:Q13639 WB:WBGene00004776 WB:WBGene00004779	F	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664111 RGD:2518	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904015	cellular response to serotonin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071418	cellular response to amine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070528	protein kinase C signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	PMID:7582481^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050795	regulation of behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042310	vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034220	ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	P	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019934	cGMP-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019722	calcium-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016310	phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014827	intestine smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010507	negative regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:10944220^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888735	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007202	activation of phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:61801	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:7582481^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001819	positive regulation of cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P41595	P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:0070528	protein kinase C signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
enables	GO:0051378	serotonin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	F	Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0019934	cGMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0014827	intestine smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	F	Seeded From UniProt	complete
involved_in	GO:0007210	serotonin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0007202	activation of phospholipase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	C	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	F	Seeded From UniProt	complete
enables	GO:0001965	G-protein alpha-subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	F	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41595 ensembl:ENSP00000258400	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000482 InterPro:IPR002231	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002231	C	Seeded From UniProt	complete
involved_in	GO:0006939	smooth muscle contraction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000482	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000482 InterPro:IPR002231	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000482	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000482 InterPro:IPR017452	C	Seeded From UniProt	complete
involved_in	GO:0042310	vasoconstriction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000482	P	Seeded From UniProt	complete
involved_in	GO:0050795	regulation of behavior	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000482	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	PMID:10944220^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004993	G protein-coupled serotonin receptor activity	PMID:10944220^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Launay, JM et al. (2006) Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB J. 20 1843-54 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Janoshazi, A et al. (2007) Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol. Pharmacol. 71 1463-74 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Launay, JM et al. (1996) Ras involvement in signal transduction by the serotonin 5-HT2B receptor. J. Biol. Chem. 271 3141-7 PubMed GONUTS page
↑ Li, B et al. (2010) Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors. Neurochem. Int. 57 432-9 PubMed GONUTS page
↑ Bevilacqua, L et al. (2010) A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468 1061-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Jaffré, F et al. (2009) Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ. Res. 104 113-23 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Choi, DS et al. (1997) 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development 124 1745-55 PubMed GONUTS page
↑ Asada, M et al. (2009) Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia 11 408-17 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 Bonhaus, DW et al. (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115 622-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Nebigil, CG et al. (2000) Serotonin 2B receptor is required for heart development. Proc. Natl. Acad. Sci. U.S.A. 97 9508-13 PubMed GONUTS page

[PMID:16940156-1] Launay, JM et al. (2006) Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB J. 20 1843-54 PubMed GONUTS page

[PMID:17325130-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Janoshazi, A et al. (2007) Modified receptor internalization upon coexpression of 5-HT1B receptor and 5-HT2B receptors. Mol. Pharmacol. 71 1463-74 PubMed GONUTS page

[PMID:8621713-3] 3.0 ^3.1 ^3.2 Launay, JM et al. (1996) Ras involvement in signal transduction by the serotonin 5-HT2B receptor. J. Biol. Chem. 271 3141-7 PubMed GONUTS page

[PMID:20450948-4] Li, B et al. (2010) Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors. Neurochem. Int. 57 432-9 PubMed GONUTS page

[PMID:21179162-5] Bevilacqua, L et al. (2010) A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468 1061-6 PubMed GONUTS page

[PMID:19023134-6] 6.0 ^6.1 Jaffré, F et al. (2009) Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ. Res. 104 113-23 PubMed GONUTS page

[PMID:9165122-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Choi, DS et al. (1997) 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development 124 1745-55 PubMed GONUTS page

[PMID:19308295-8] Asada, M et al. (2009) Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Neoplasia 11 408-17 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7582481-10] 10.0 ^10.1 Bonhaus, DW et al. (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115 622-8 PubMed GONUTS page

[PMID:10944220-11] 11.0 ^11.1 ^11.2 Nebigil, CG et al. (2000) Serotonin 2B receptor is required for heart development. Proc. Natl. Acad. Sci. U.S.A. 97 9508-13 PubMed GONUTS page

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MOUSE:5HT2B

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