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HUMAN:SRP68

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SRP68
Protein Name(s) Signal recognition particle subunit SRP68

SRP68 Signal recognition particle 68 kDa protein

External Links
UniProt Q9UHB9
EMBL AF195951
AK074698
AK097962
AK126258
AC040980
CH471099
CH471099
BC020238
CCDS CCDS11738.1
CCDS58600.1
CCDS58601.1
RefSeq NP_001247431.1
NP_001247432.1
NP_055045.2
UniGene Hs.514495
PDB 4P3E
4P3F
PDBsum 4P3E
4P3F
ProteinModelPortal Q9UHB9
SMR Q9UHB9
BioGrid 112608
IntAct Q9UHB9
MINT MINT-3080223
STRING 9606.ENSP00000312066
TCDB 3.A.5.9.1
PhosphoSite Q9UHB9
DMDM 37154869
MaxQB Q9UHB9
PaxDb Q9UHB9
PeptideAtlas Q9UHB9
PRIDE Q9UHB9
Ensembl ENST00000307877
ENST00000539137
ENST00000602720
GeneID 6730
KEGG hsa:6730
UCSC uc002jqj.2
uc002jqk.2
uc002jql.2
CTD 6730
GeneCards GC17M074035
HGNC HGNC:11302
HPA HPA023303
MIM 604858
neXtProt NX_Q9UHB9
PharmGKB PA36126
eggNOG NOG325632
GeneTree ENSGT00390000011856
HOGENOM HOG000231195
HOVERGEN HBG059793
InParanoid Q9UHB9
KO K03107
OMA IGDQSAM
OrthoDB EOG7C5M7W
PhylomeDB Q9UHB9
TreeFam TF105779
Reactome REACT_115902
ChiTaRS SRP68
GenomeRNAi 6730
NextBio 26254
PRO PR:Q9UHB9
Proteomes UP000005640
Bgee Q9UHB9
CleanEx HS_SRP68
ExpressionAtlas Q9UHB9
Genevestigator Q9UHB9
GO GO:0005829
GO:0005783
GO:0005730
GO:0005840
GO:0005786
GO:0008312
GO:0030942
GO:0044822
GO:0005047
GO:0044267
GO:0010467
GO:0042493
GO:0006614
GO:0006412
InterPro IPR026258
PIRSF PIRSF038995

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

PMID:24455187[1]

ECO:0000314

Figure 2 shows apoptosis is induced by an excess of SRP proteins and proteotoxic stress

Missing: GO ID
CACAO 9409

contributes_to

GO:0043022

ribosome binding

PMID:27899666[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0048500

signal recognition particle

PMID:27899666[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008312

7S RNA binding

PMID:27899666[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019904

protein domain specific binding

PMID:27899666[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O76094

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:18089836[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005786

signal recognition particle, endoplasmic reticulum targeting

PMID:18089836[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005047

signal recognition particle binding

PMID:17254600[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O76094

F

Seeded From UniProt

complete

part_of

GO:0005786

signal recognition particle, endoplasmic reticulum targeting

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304791
SGD:S000006164
UniProtKB:Q9UHB9

C

Seeded From UniProt

complete

enables

GO:0005047

signal recognition particle binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000304791
UniProtKB:Q9UHB9

F

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034652

F

Seeded From UniProt

complete

enables

GO:0005047

signal recognition particle binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026258

F

Seeded From UniProt

complete

part_of

GO:0005786

signal recognition particle, endoplasmic reticulum targeting

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026258

C

Seeded From UniProt

complete

involved_in

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026258

P

Seeded From UniProt

complete

enables

GO:0008312

7S RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026258

F

Seeded From UniProt

complete

enables

GO:0030942

endoplasmic reticulum signal peptide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026258

F

Seeded From UniProt

complete

part_of

GO:0005840

ribosome

PMID:10618370[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005786

signal recognition particle, endoplasmic reticulum targeting

PMID:10618370[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:10618370[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:10618370[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

Reactome:R-HSA-1799339

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1799332

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005786

signal recognition particle, endoplasmic reticulum targeting

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0733

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Baryakin, DN et al. (2013) Alu- and 7SL RNA Analogues Suppress MCF-7 Cell Viability through Modulating the Transcription of Endoplasmic Reticulum Stress Response Genes. Acta Naturae 5 83-93 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Becker, MM et al. (2017) Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction. Nucleic Acids Res. 45 470-481 PubMed GONUTS page
  3. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. ↑ 4.0 4.1 Yoshida, M et al. (2008) A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads. Mol. Pharmacol. 73 987-94 PubMed GONUTS page
  5. ↑ Menichelli, E et al. (2007) Protein-induced conformational changes of RNA during the assembly of human signal recognition particle. J. Mol. Biol. 367 187-203 PubMed GONUTS page
  6. ↑ 6.0 6.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Politz, JC et al. (2000) Signal recognition particle components in the nucleolus. Proc. Natl. Acad. Sci. U.S.A. 97 55-60 PubMed GONUTS page
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