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Category:Team BAMF

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableMYCTU:FABGEturner, Team BAMF2014-02-01 19:22:23 CSTGO:0030497 fatty acid elongation (P)PMID:11932442ECO:0000314 direct assay evidence used in manual assertion

Figure 1

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unacceptableYEAST:ABF1Eturner, Team BAMF2014-02-01 19:07:33 CSTGO:0001968 fibronectin binding (F)PMID:1386839ECO:0000314 direct assay evidence used in manual assertion

Figure 6

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unacceptableHUMAN:TNFAAross, Team BAMF2014-02-01 18:02:17 CSTGO:0010468 regulation of gene expression (P)PMID:23914732ECO:0000314 direct assay evidence used in manual assertion

Figure 1A: Human macrophages were treated with increasing doses of TNFa. Using PCR, the levels of mRNA were measured. As the dose of mRNA increased, the level of ABCA1 mRNA decreased.

challenge
unacceptableHUMAN:TNFAAross, Team BAMF2014-02-01 17:54:13 CSTGO:0010874 regulation of cholesterol efflux (P)PMID:23914732ECO:0000314 direct assay evidence used in manual assertion

Figure 1: Human macrophages were labeled with 3H-cholesterol. TNFa was added to the cell cultures in increasing doses. apoA-I or HDL were added. The figures show that cholesterol efflux decreased in a dose-dependent manner in cells treated with TNFa.

challenge
updatedbyinstructorDROME:ABLAross, Team BAMF2014-02-01 15:35:04 CSTGO:0010977 negative regulation of neuron projection development (P)PMID:24466097ECO:0000315 mutant phenotype evidence used in manual assertion

Consistent with the altered neuronal growth in the larval CNS culture [24], neurons in Abl cultures displayed... more swollen, dark nodes along neurites (Fig. 4B1).

challenge
updatedbyinstructorDROME:ABLAross, Team BAMF2014-02-01 15:24:43 CSTGO:0010592 positive regulation of lamellipodium assembly (P)PMID:24466097ECO:0000315 mutant phenotype evidence used in manual assertion

Compared to WT control, Abl neurons exhibited tendency to show fewer veil-like structures and well developed, large lamellipodia (>4 µm2) occurred only at a lower frequency (Fig. 5)

challenge
unacceptableEBOZM:VP30Eturner, Team BAMF2014-01-30 16:58:48 CSTGO:0043021 ribonucleoprotein complex binding (F)PMID:17567691ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows that when this protein is present it binds to RNA

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unacceptableYEFV1:POLGEturner, Team BAMF2014-01-30 16:36:05 CSTGO:0031079 picornain 3C activity (F)PMID:15831952ECO:0000314 direct assay evidence used in manual assertion

Figure 5 showed that different mutations in this protein caused different effects in cleavage

challenge
unacceptableHUMAN:M3KL4Eturner, Team BAMF2014-01-30 15:58:29 CSTGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway (P)PMID:21602844ECO:0000314 direct assay evidence used in manual assertion

Looking at Figure 5 it proves that this protein negatively regulates LSP

challenge
unacceptableHUMAN:FOXO1Aross, Team BAMF2014-01-27 21:06:57 CSTGO:0005634 nucleus (C)PMID:18079193ECO:0000314 direct assay evidence used in manual assertion

Figure 1A shows staining of C2C12 cells expressing FoxO1-3A-ER. The cells were immunostained using anti-ER and DAPI nuclear staining. The control showed some overlap of areas showing staining for FoxO1-3A-ER and DAPI(nuclear stain), but when the cells were treated with 4-HT, there was more overlap of FoxO1-3A-ER and DAPI stained areas. This suggests after treatment with 4-HT, FoxO1-3A-ER was located in the nucleus.

challenge

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Pages in category "Team BAMF"

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