EBOZM:VP30

Species (Taxon ID)	Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus). (128952)
Gene Name(s)	VP30
Protein Name(s)	Minor nucleoprotein VP30 Transcription activator VP30
External Links
UniProt	Q05323
EMBL	L11365 AF086833 AF499101 AY142960 AF272001
RefSeq	NP_066249.1
DisProt	DP00627
ProteinModelPortal	Q05323
SMR	Q05323
GeneID	911826
Proteomes	UP000007209
GO	GO:0030430 GO:0030529 GO:0019013 GO:0046872 GO:0003723 GO:0050434 GO:0044414 GO:0006351
InterPro	IPR014459
Pfam	PF11507
PIRSF	PIRSF011356

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044414	suppression of host defenses	PMID:21228243	ECO:0000315			P		Fig. 2 Suppression of siRNA	complete CACAO 2417
	GO:0030529	ribonucleoprotein complex	PMID:19041915	ECO:0000314			C		Figure 3: VP30 was coexpressed in a plasmid with known Ribonucleoprotein complex components NP and L. Antisera against all components were used in two-color co-immunofluorescence. This figure shows that VP30 was able to be co-localized with both known RNP components, forming a bridge.	complete CACAO 6379
	GO:0050434	positive regulation of viral transcription	PMID:9971816	ECO:0000314			P		Figure 4B—a Northern blot that indicates significant increase in mRNA production in the present of VP30 and negligible or no mRNA production in its absence. This is supported by the CAT assay in Figure 4C, which shows a significant increase in mRNA expression with increase of VP30 concentration. This indicate that VP30 plays a significant role in increasing transcription activity in the Ebola virus.	complete CACAO 6383
	GO:0043021	ribonucleoprotein complex binding	PMID:17567691	ECO:0000314			F		Figure 3 shows that when this protein is present it binds to RNA	complete CACAO 9335
involved_in	GO:0050434	positive regulation of viral transcription	PMID:9971816	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044414	suppression of host defenses	PMID:21228243	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:17567691	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:17567691	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003727	single-stranded RNA binding	PMID:17567691	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:17567691	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C		Seeded From UniProt	complete
part_of	GO:0019013	viral nucleocapsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0543	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
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References

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