YEAST:ABF1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	ABF1 (synonyms: BAF1, OBF1, REB2, SBF1)
Protein Name(s)	ARS-binding factor 1 Bidirectionally acting factor 1 DNA replication enhancer-binding protein OBF1 SFB-B
External Links
UniProt	P14164
EMBL	X16385 X51654 M29067 M63578 S93804 Z28111 X77511 BK006944
PIR	S29870
RefSeq	NP_012810.1
ProteinModelPortal	P14164
BioGrid	34022
DIP	DIP-2199N
IntAct	P14164
MINT	MINT-2783533
STRING	4932.YKL112W
MaxQB	P14164
PaxDb	P14164
PeptideAtlas	P14164
EnsemblFungi	[example_ID YKL112W]
GeneID	853748
KEGG	sce:YKL112W
SGD	S000001595
eggNOG	NOG43177
InParanoid	P14164
KO	K09249
OMA	ACHLKNC
OrthoDB	EOG7KSXM9
BioCyc	YEAST:G3O-31897-MONOMER
NextBio	974810
Proteomes	UP000002311
Genevestigator	P14164
GO	GO:0000113 GO:0005634 GO:0003688 GO:0000978 GO:0001077 GO:0043565 GO:0044374 GO:0006338 GO:0030466 GO:0006261 GO:0070911 GO:0000122 GO:0045944
InterPro	IPR006774
Pfam	PF04684

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0043565	sequence-specific DNA binding	PMID:19111667^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:27016735^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0001968	fibronectin binding	PMID:1386839^[3]	ECO:0000314			F		Figure 6	complete CACAO 9400
involved_in	GO:0070911	global genome nucleotide-excision repair	PMID:10601031^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070911	global genome nucleotide-excision repair	PMID:15177043^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15192094^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044374	sequence-specific DNA binding, bending	PMID:8206955^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:3275867^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:7663308^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:16908533^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030466	chromatin silencing at silent mating-type cassette	PMID:8582634^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:11713306^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000029652	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:10684934^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005693	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:10684934^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:11713306^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006261	DNA-dependent DNA replication	PMID:11756546^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15522095^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15522095^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003688	DNA replication origin binding	PMID:3281162^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003688	DNA replication origin binding	PMID:16824194^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:7663308^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:7663308^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15192094^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000113	nucleotide-excision repair factor 4 complex	PMID:10601031^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006774	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006774	C		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006774	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Badis, G et al. (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol. Cell 32 878-87 PubMed GONUTS page
↑ Fermi, B et al. (2016) Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes in Saccharomyces cerevisiae. Nucleic Acids Res. 44 6113-26 PubMed GONUTS page
↑ Talay, SR et al. (1992) Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells. Infect. Immun. 60 3837-44 PubMed GONUTS page
↑ ^4.0 ^4.1 Reed, SH et al. (1999) Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair. Genes Dev. 13 3052-8 PubMed GONUTS page
↑ Yu, S et al. (2004) The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair. DNA Repair (Amst.) 3 277-87 PubMed GONUTS page
↑ ^6.0 ^6.1 Miyake, T et al. (2004) Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae. J. Biol. Chem. 279 34865-72 PubMed GONUTS page
↑ McBroom, LD & Sadowski, PD (1994) DNA bending by Saccharomyces cerevisiae ABF1 and its proteolytic fragments. J. Biol. Chem. 269 16461-8 PubMed GONUTS page
↑ Buchman, AR et al. (1988) Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae. Mol. Cell. Biol. 8 210-25 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Yoo, HY et al. (1995) Transcriptional control of the Saccharomyces cerevisiae ADH1 gene by autonomously replicating sequence binding factor 1. Curr. Microbiol. 31 163-8 PubMed GONUTS page
↑ Zou, Y et al. (2006) Asymmetric positioning of nucleosomes and directional establishment of transcriptionally silent chromatin by Saccharomyces cerevisiae silencers. Mol. Cell. Biol. 26 7806-19 PubMed GONUTS page
↑ Loo, S et al. (1995) Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae. Genetics 141 889-902 PubMed GONUTS page
↑ ^12.0 ^12.1 Bodmer-Glavas, M et al. (2001) RNA polymerase II and III transcription factors can stimulate DNA replication by modifying origin chromatin structures. Nucleic Acids Res. 29 4570-80 PubMed GONUTS page
↑ ^13.0 ^13.1 Lascaris, RF et al. (2000) Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene. Nucleic Acids Res. 28 1390-6 PubMed GONUTS page
↑ Miyake, T et al. (2002) Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing. Mol. Cell. Biol. 22 505-16 PubMed GONUTS page
↑ ^15.0 ^15.1 Loch, CM et al. (2004) Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery. Traffic 5 925-35 PubMed GONUTS page
↑ Diffley, JF & Stillman, B (1988) Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. U.S.A. 85 2120-4 PubMed GONUTS page
↑ Kawasaki, Y et al. (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11 745-56 PubMed GONUTS page

[PMID:19111667-1] Badis, G et al. (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol. Cell 32 878-87 PubMed GONUTS page

[PMID:27016735-2] Fermi, B et al. (2016) Promoter architecture and transcriptional regulation of Abf1-dependent ribosomal protein genes in Saccharomyces cerevisiae. Nucleic Acids Res. 44 6113-26 PubMed GONUTS page

[PMID:1386839-3] Talay, SR et al. (1992) Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells. Infect. Immun. 60 3837-44 PubMed GONUTS page

[PMID:10601031-4] 4.0 ^4.1 Reed, SH et al. (1999) Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair. Genes Dev. 13 3052-8 PubMed GONUTS page

[PMID:15177043-5] Yu, S et al. (2004) The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair. DNA Repair (Amst.) 3 277-87 PubMed GONUTS page

[PMID:15192094-6] 6.0 ^6.1 Miyake, T et al. (2004) Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae. J. Biol. Chem. 279 34865-72 PubMed GONUTS page

[PMID:8206955-7] McBroom, LD & Sadowski, PD (1994) DNA bending by Saccharomyces cerevisiae ABF1 and its proteolytic fragments. J. Biol. Chem. 269 16461-8 PubMed GONUTS page

[PMID:3275867-8] Buchman, AR et al. (1988) Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae. Mol. Cell. Biol. 8 210-25 PubMed GONUTS page

[PMID:7663308-9] 9.0 ^9.1 ^9.2 Yoo, HY et al. (1995) Transcriptional control of the Saccharomyces cerevisiae ADH1 gene by autonomously replicating sequence binding factor 1. Curr. Microbiol. 31 163-8 PubMed GONUTS page

[PMID:16908533-10] Zou, Y et al. (2006) Asymmetric positioning of nucleosomes and directional establishment of transcriptionally silent chromatin by Saccharomyces cerevisiae silencers. Mol. Cell. Biol. 26 7806-19 PubMed GONUTS page

[PMID:8582634-11] Loo, S et al. (1995) Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae. Genetics 141 889-902 PubMed GONUTS page

[PMID:11713306-12] 12.0 ^12.1 Bodmer-Glavas, M et al. (2001) RNA polymerase II and III transcription factors can stimulate DNA replication by modifying origin chromatin structures. Nucleic Acids Res. 29 4570-80 PubMed GONUTS page

[PMID:10684934-13] 13.0 ^13.1 Lascaris, RF et al. (2000) Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene. Nucleic Acids Res. 28 1390-6 PubMed GONUTS page

[PMID:11756546-14] Miyake, T et al. (2002) Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing. Mol. Cell. Biol. 22 505-16 PubMed GONUTS page

[PMID:15522095-15] 15.0 ^15.1 Loch, CM et al. (2004) Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery. Traffic 5 925-35 PubMed GONUTS page

[PMID:3281162-16] Diffley, JF & Stillman, B (1988) Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer. Proc. Natl. Acad. Sci. U.S.A. 85 2120-4 PubMed GONUTS page

[PMID:16824194-17] Kawasaki, Y et al. (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11 745-56 PubMed GONUTS page

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YEAST:ABF1

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