HUMAN:M3KL4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MLK4 (ECO:0000303 with Ref.1) (synonyms: KIAA1804 (ECO:0000312 with EMBL:BAB47433.1))
Protein Name(s)	Mitogen-activated protein kinase kinase kinase MLK4 Mixed lineage kinase 4
External Links
UniProt	Q5TCX8
EMBL	AJ311797 AJ311798 AB058707 AL133380 AL133380 AL133380 CH471098 BC136648 BC136649
CCDS	CCDS1598.1
RefSeq	NP_115811.2
UniGene	Hs.547779
ProteinModelPortal	Q5TCX8
SMR	Q5TCX8
BioGrid	124089
IntAct	Q5TCX8
PhosphoSite	Q5TCX8
DMDM	71153820
MaxQB	Q5TCX8
PaxDb	Q5TCX8
PRIDE	Q5TCX8
GeneID	84451
KEGG	hsa:84451
UCSC	uc001hvs.1 uc001hvt.4 uc001hvu.4
CTD	84451
GeneCards	GC01P233463
H-InvDB	HIX0001705
HPA	HPA007636
MIM	614793
neXtProt	NX_Q5TCX8
eggNOG	COG0515
GeneTree	ENSGT00760000118807
HOVERGEN	HBG067662
InParanoid	Q5TCX8
KO	K17534
OMA	CEEPKLS
PhylomeDB	Q5TCX8
ChiTaRS	KIAA1804
GenomeRNAi	84451
NextBio	74235
PRO	PR:Q5TCX8
Proteomes	UP000005640
Bgee	Q5TCX8
ExpressionAtlas	Q5TCX8
Genevestigator	Q5TCX8
GO	GO:0005524 GO:0004709 GO:0042803 GO:0004713 GO:0007257 GO:0046777 GO:0006468
InterPro	IPR011009 IPR016231 IPR000719 IPR017441 IPR001245 IPR008271 IPR001452 IPR020635
Pfam	PF07714 PF14604
PIRSF	PIRSF000556
PRINTS	PR00452 PR00109
SMART	SM00326 SM00219
SUPFAM	SSF50044 SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16584	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16584	F		Seeded From UniProt	complete
Colocalizes with	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	PMID:21602844	ECO:0000314			P		Looking at Figure 5 it proves that this protein negatively regulates LSP	complete CACAO 9329
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16584	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16584	P		Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004709	P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004709	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016231	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.25	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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References

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