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MYCTU:FABG
Contents
| Species (Taxon ID) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). (83332) | |
| Gene Name(s) | fabG1 (synonyms: mabA) | |
| Protein Name(s) | 3-oxoacyl-[acyl-carrier-protein] reductase FabG1
3-ketoacyl-acyl carrier protein reductase Beta-ketoacyl-ACP reductase Beta-ketoacyl-acyl carrier protein reductase | |
| External Links | ||
| UniProt | P9WGT3 | |
| EMBL | U66801 AL123456 | |
| PIR | F70710 | |
| RefSeq | NP_215999.1 YP_006514867.1 | |
| PDB | 1UZL 1UZM 1UZN 2NTN | |
| PDBsum | 1UZL 1UZM 1UZN 2NTN | |
| ProteinModelPortal | P9WGT3 | |
| SMR | P9WGT3 | |
| GeneID | 13320076 886551 | |
| KEGG | mtu:Rv1483 mtv:RVBD_1483 | |
| TubercuList | Rv1483 | |
| KO | K11610 | |
| OMA | ANACLFF | |
| PhylomeDB | P9WGT3 | |
| UniPathway | UPA00094 | |
| Proteomes | UP000001584 | |
| GO | GO:0005886 GO:0004316 GO:0018454 GO:0071768 GO:0055114 GO:0046459 | |
| Gene3D | 3.40.50.720 | |
| InterPro | IPR002198 IPR002347 IPR016040 IPR020904 | |
| Pfam | PF00106 | |
| PRINTS | PR00081 PR00080 | |
| PROSITE | PS00061 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071768 |
mycolic acid biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046459 |
short-chain fatty acid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0030497 |
fatty acid elongation |
ECO:0000314 |
P |
Figure 1 |
complete | |||||
|
enables |
GO:0018454 |
acetoacetyl-CoA reductase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004316 |
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004316 |
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004316 |
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070402 |
NADPH binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102131 |
3-oxo-glutaryl-[acp] methyl ester reductase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102132 |
3-oxo-pimeloyl-[acp] methyl ester reductase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004316 |
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006633 |
fatty acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0275 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Gu, S et al. (2003) Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain. Mol. Cell Proteomics 2 1284-96 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Marrakchi, H et al. (2002) MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II. Microbiology (Reading, Engl.) 148 951-60 PubMed GONUTS page
- ↑ 3.0 3.1 Gurvitz, A (2009) The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2. Mol. Genet. Genomics 282 407-16 PubMed GONUTS page
- ↑ Silva, RG et al. (2006) Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms. Biochemistry 45 13064-73 PubMed GONUTS page
- ↑ Banerjee, A et al. (1998) The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Microbiology (Reading, Engl.) 144 ( Pt 10) 2697-704 PubMed GONUTS page
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