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YEFV1:POLG
Contents
| Species (Taxon ID) | Yellow fever virus (strain 17D vaccine) (YFV). (11090) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Genome polyprotein
Capsid protein C Core protein prM Peptide pr Small envelope protein M Matrix protein Envelope protein E Non-structural protein 1 NS1 Non-structural protein 2A NS2A Non-structural protein 2A-alpha NS2A-alpha Serine protease subunit NS2B Flavivirin protease NS2B regulatory subunit Non-structural protein 2B Serine protease NS3 Flavivirin protease NS3 catalytic subunit Non-structural protein 3 Non-structural protein 4A NS4A Peptide 2k Non-structural protein 4B NS4B RNA-directed RNA polymerase NS5 Non-structural protein 5 | |
| External Links | ||
| UniProt | P03314 | |
| EMBL | X03700 X15062 U17066 U17067 AF052437 AF052438 AF052439 AF052444 AF052445 AF052446 DQ118157 DQ100292 | |
| PIR | A03914 S07757 | |
| RefSeq | NP_041726.1 | |
| PDB | 1NA4 1YKS 1YMF 3EVA 3EVB 3EVC 3EVD 3EVE 3EVF | |
| PDBsum | 1NA4 1YKS 1YMF 3EVA 3EVB 3EVC 3EVD 3EVE 3EVF | |
| ProteinModelPortal | P03314 | |
| SMR | P03314 | |
| PRIDE | P03314 | |
| GeneID | 1502173 | |
| EvolutionaryTrace | P03314 | |
| Proteomes | UP000000360 | |
| GO | GO:0044167 GO:0042025 GO:0016021 GO:0019028 GO:0019031 GO:0055036 GO:0005524 GO:0008026 GO:0003725 GO:0046872 GO:0004482 GO:0004483 GO:0003724 GO:0003968 GO:0004252 GO:0070008 GO:0005198 GO:0075512 GO:0039654 GO:0039520 GO:0006355 GO:0039502 GO:0006351 GO:0039694 GO:0019062 | |
| Gene3D | 2.60.40.350 2.60.98.10 3.30.387.10 3.40.50.150 3.40.50.300 | |
| InterPro | IPR011492 IPR000069 IPR013755 IPR001122 IPR026470 IPR001157 IPR000752 IPR000487 IPR000404 IPR001528 IPR002535 IPR000336 IPR001850 IPR027287 IPR014412 IPR011998 IPR013754 IPR014001 IPR001650 IPR014756 IPR026490 IPR027417 IPR000208 IPR007094 IPR002877 IPR029063 IPR009003 | |
| Pfam | PF01003 PF07652 PF02832 PF00869 PF01004 PF00948 PF01005 PF01002 PF01350 PF01349 PF00972 PF01570 PF01728 PF00271 PF00949 | |
| PIRSF | PIRSF003817 | |
| SMART | SM00487 SM00490 | |
| SUPFAM | SSF50494 SSF52540 SSF53335 SSF56983 SSF81296 | |
| TIGRFAMs | TIGR04240 | |
| PROSITE | PS51527 PS51528 PS51192 PS50507 PS51591 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0031079 |
picornain 3C activity |
ECO:0000314 |
F |
Figure 5 showed that different mutations in this protein caused different effects in cleavage |
complete | |||||
| GO:0019031 |
viral envelope |
ECO:0000315 |
C |
The infection rate of the 17D/Asibi M-E E T380R mutant (table 1) shows how the T380R mutation in EDIII favored the establishment of the viral infection in Ae. aegypti |
complete | |||||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001172 |
transcription, RNA-templated |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0003968 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080009 |
mRNA methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080009 |
mRNA methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0106005 |
RNA 5'-cap (guanine-N7)-methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004482 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0106005 |
RNA 5'-cap (guanine-N7)-methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004482 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003724 |
RNA helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003725 |
double-stranded RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004482 |
mRNA (guanine-N7-)-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004483 |
mRNA (nucleoside-2'-O-)-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005198 |
structural molecule activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008026 |
ATP-dependent helicase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016070 |
RNA metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016817 |
hydrolase activity, acting on acid anhydrides |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019058 |
viral life cycle |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039694 |
viral RNA genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004482 |
mRNA (guanine-N7-)-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017111 |
nucleoside-triphosphatase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004483 |
mRNA (nucleoside-2'-O-)-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900369 |
negative regulation of RNA interference |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046762 |
viral budding from ER membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004483 |
mRNA (nucleoside-2'-O-)-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004482 |
mRNA (guanine-N7-)-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006370 |
7-methylguanosine mRNA capping |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004482 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0080009 |
mRNA methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004483 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0106005 |
RNA 5'-cap (guanine-N7)-methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004482 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046762 |
viral budding from ER membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019028 |
viral capsid |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075509 |
endocytosis involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006370 |
7-methylguanosine mRNA capping |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044165 |
host cell endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003968 |
RNA-directed 5'-3' RNA polymerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046718 |
viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039663 |
membrane fusion involved in viral entry into host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019062 |
virion attachment to host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039564 |
suppression by virus of host STAT2 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039520 |
induction by virus of host autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019031 |
viral envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016779 |
nucleotidyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030430 |
host cell cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0075512 |
clathrin-dependent endocytosis of virus by host cell |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039654 |
fusion of virus membrane with host endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044167 |
host cell endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055036 |
virion membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044220 |
host cell perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Chambers, TJ et al. (2005) Yellow fever virus NS2B-NS3 protease: characterization of charged-to-alanine mutant and revertant viruses and analysis of polyprotein-cleavage activities. J. Gen. Virol. 86 1403-13 PubMed GONUTS page
- ↑ 2.0 2.1 Huang, YJ et al. (2014) Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus. Virol. J. 11 60 PubMed GONUTS page
- ↑ Samuel, GH et al. (2016) Yellow fever virus capsid protein is a potent suppressor of RNA silencing that binds double-stranded RNA. Proc. Natl. Acad. Sci. U.S.A. 113 13863-13868 PubMed GONUTS page
- ↑ 4.0 4.1 Op De Beeck, A et al. (2004) The transmembrane domains of the prM and E proteins of yellow fever virus are endoplasmic reticulum localization signals. J. Virol. 78 12591-602 PubMed GONUTS page
- ↑ Muñoz-Jordán, JL et al. (2005) Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J. Virol. 79 8004-13 PubMed GONUTS page
- ↑ 6.0 6.1 Issur, M et al. (2009) The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure. RNA 15 2340-50 PubMed GONUTS page
- ↑ Laurent-Rolle, M et al. (2014) The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon. Cell Host Microbe 16 314-327 PubMed GONUTS page
h
- GO:0004386 ! helicase activity
- GO:0030430 ! host cell cytoplasm
- GO:0044165 ! host cell endoplasmic reticulum
- GO:0044167 ! host cell endoplasmic reticulum membrane
- GO:0033644 ! host cell membrane
- GO:0042025 ! host cell nucleus
- GO:0044220 ! host cell perinuclear region of cytoplasm
- GO:0016787 ! hydrolase activity
- GO:0016817 ! hydrolase activity, acting on acid anhydrides
m
- GO:0016020 ! membrane
- GO:0039663 ! membrane fusion involved in viral entry into host cell
- GO:0008152 ! metabolic process
- GO:0046872 ! metal ion binding
- GO:0032259 ! methylation
- GO:0008168 ! methyltransferase activity
- GO:0030683 ! mitigation of host immune response by virus
- GO:0004483 ! mRNA (nucleoside-2'-O-)-methyltransferase activity
- GO:0004482 ! mRNA 5'-cap (guanine-N7-)-methyltransferase activity
- GO:0006397 ! mRNA processing
n
o
p
r
s
- GO:0008236 ! serine-type peptidase activity
- GO:0004252 ! serine-type endopeptidase activity
- ssRNA positive-strand viruses, no DNA stage
- GO:0005198 ! structural molecule activity
- GO:0039564 ! symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
- GO:0039502 ! symbiont-mediated suppression of host type I interferon-mediated signaling pathway
- GO:0039520 ! symbiont-mediated activation of host autophagy
- GO:0046718 ! symbiont entry into host cell
v
- GO:0046762 ! viral budding from endoplasmic reticulum membrane
- GO:0019028 ! viral capsid
- GO:0019031 ! viral envelope
- GO:0019058 ! viral life cycle
- GO:0016032 ! viral process
- GO:0039694 ! viral RNA genome replication
- GO:0019012 ! virion
- GO:0019062 ! virion attachment to host cell
- GO:0055036 ! virion membrane
- Viruses
