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PMID:24678844
| Citation |
Huang, YJ, Nuckols, JT, Horne, KM, Vanlandingham, D, Lobigs, M and Higgs, S (2014) Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus. Virol. J. 11:60 |
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| Abstract |
The RGD motif in the mosquito-borne flaviviruses envelope protein domain III (EDIII) FG loop was shown to bind negatively charged cellular molecules and mediate virus entry in mammals. However, its importance in virus entry in the mosquito has not yet been defined. The sequences of RGD motifs are conserved in JEV-serocomplex members primarily transmitted by Culex mosquitoes but absent from members of the DENV serocomplex, which utilize Aedes mosquitoes as vectors. Interestingly, the RGD sequence is present in the attenuated 17D strain of yellow fever virus as a result of the T380R mutation in the EDIII of Asibi strain following extensive in vitro passage in mice and chicken embryos and was found to contribute to the more rapid clearance in mice challenged with 17D. However, viral infectivity and dissemination in mosquitoes had not been evaluated for this mutant. |
| Links |
PubMed PMC3974419 Online version:10.1186/1743-422X-11-60 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0019031: viral envelope |
ECO:0000315: |
C |
The infection rate of the 17D/Asibi M-E E T380R mutant (table 1) shows how the T380R mutation in EDIII favored the establishment of the viral infection in Ae. aegypti |
complete | ||||
|
part_of |
GO:0019031: viral envelope |
ECO:0000315: mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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