User:Aross

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:FOXO1	2014-01-27 21:06:57 CST	GO:0005634 nucleus (C)	PMID:18079193	ECO:0000314 direct assay evidence used in manual assertion	Figure 1A shows staining of C2C12 cells expressing FoxO1-3A-ER. The cells were immunostained using anti-ER and DAPI nuclear staining. The control showed some overlap of areas showing staining for FoxO1-3A-ER and DAPI(nuclear stain), but when the cells were treated with 4-HT, there was more overlap of FoxO1-3A-ER and DAPI stained areas. This suggests after treatment with 4-HT, FoxO1-3A-ER was located in the nucleus.	challenge
updatedbyinstructor	DROME:ABL	2014-02-01 15:24:43 CST	GO:0010592 positive regulation of lamellipodium assembly (P)	PMID:24466097	ECO:0000315 mutant phenotype evidence used in manual assertion	Compared to WT control, Abl neurons exhibited tendency to show fewer veil-like structures and well developed, large lamellipodia (>4 µm2) occurred only at a lower frequency (Fig. 5)	challenge
updatedbyinstructor	DROME:ABL	2014-02-01 15:35:04 CST	GO:0010977 negative regulation of neuron projection development (P)	PMID:24466097	ECO:0000315 mutant phenotype evidence used in manual assertion	Consistent with the altered neuronal growth in the larval CNS culture [24], neurons in Abl cultures displayed... more swollen, dark nodes along neurites (Fig. 4B1).	challenge
unacceptable	HUMAN:TNFA	2014-02-01 17:54:13 CST	GO:0010874 regulation of cholesterol efflux (P)	PMID:23914732	ECO:0000314 direct assay evidence used in manual assertion	Figure 1: Human macrophages were labeled with 3H-cholesterol. TNFa was added to the cell cultures in increasing doses. apoA-I or HDL were added. The figures show that cholesterol efflux decreased in a dose-dependent manner in cells treated with TNFa.	challenge
unacceptable	HUMAN:TNFA	2014-02-01 18:02:17 CST	GO:0010468 regulation of gene expression (P)	PMID:23914732	ECO:0000314 direct assay evidence used in manual assertion	Figure 1A: Human macrophages were treated with increasing doses of TNFa. Using PCR, the levels of mRNA were measured. As the dose of mRNA increased, the level of ABCA1 mRNA decreased.	challenge

acceptable:0
unacceptable:3
requires_changes:0
flagged:0

Annotations challenged by Aross

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Grolfe, Team Pancakes At Nite	HUMAN:CIB1	GO:0051592 - response to calcium ion (P)	PMID:20473878	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
updatedbyinstructor	Csobelman, Team Lobster Soul	CHICK:MLE1	GO:0043520 - regulation of myosin II filament assembly (P)	PMID:1464306	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 6 fixed by Djgulizia
updatedbyinstructor	Rthompson, Team Bfast Taco	RAT:TAU	GO:0005874 - microtubule (C)	PMID:1396588	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2 fixed by Michelel
unacceptable	Rthompson, Team Bfast Taco	HUMAN:OPSD	GO:0071482 - cellular response to light stimulus (P)	PMID:8643442	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4
updatedbyinstructor	Aross, Team BAMF	DROME:ABL	GO:0010977 - negative regulation of neuron projection development (P)	PMID:24466097	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4

0 annotations fixed by Aross

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