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Category:Team Pancakes At Nite

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableHUMAN:FOXO1Malexander2, Team Pancakes At Nite2014-02-08 11:52:15 CSTGO:0048523 negative regulation of cellular process (P)PMID:18079193ECO:0000314 direct assay evidence used in manual assertion

Figure 2A shows the effect on the production of raptor by the FOX01 when exposed to 4-HT versus when not. The figure shows that over time the production of raptor decreased when exposed to 4-HT versus not.

challenge
unacceptableHUMAN:ANGIGrolfe, Team Pancakes At Nite2014-02-06 17:13:53 CSTGO:0005730 nucleolus (C)PMID:24356419ECO:0000314 direct assay evidence used in manual assertion

Figure 2A provides data confirming that ANG is in the nucleus of Hela cells.

challenge
updatedbyinstructorHUMAN:CIB1Malexander2, Team Pancakes At Nite2014-01-30 21:17:55 CSTGO:0030291 protein serine/threonine kinase inhibitor activity (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Fig 5

challenge
updatedbyinstructorHUMAN:CIB1Malexander2, Team Pancakes At Nite2014-01-30 21:04:19 CSTGO:0005886 plasma membrane (C)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

In figure 2Aii, CIB1 is seen localized along the cell membrane indicating plasma membrane localization as visualized in H & E stains.

challenge
updatedbyinstructorHUMAN:PLS1Grolfe, Team Pancakes At Nite2014-01-30 19:56:39 CSTGO:0005730 nucleolus (C)PMID:24356419ECO:0000314 direct assay evidence used in manual assertion

Figure 2A-C provides data confirming that ANG is in the nucleus of Hela cells.

challenge
unacceptableHUMAN:FAK2Malexander2, Team Pancakes At Nite2014-01-29 19:02:10 CSTGO:0033673 negative regulation of kinase activity (P)PMID:18339875ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that after treatment with PF-562,271 more cells that were treated with 1.1 micro mole/L were in S and G2-M phase than other cells.

challenge
updatedbyinstructorHUMAN:FAK2Malexander2, Team Pancakes At Nite2014-01-29 18:42:38 CSTGO:0038083 peptidyl-tyrosine autophosphorylation (P)PMID:9545257ECO:0000314 direct assay evidence used in manual assertion

Figure 5

challenge
updatedbyinstructorHUMAN:BTKMalexander2, Team Pancakes At Nite2014-01-29 17:56:38 CSTGO:0018108 peptidyl-tyrosine phosphorylation (P)PMID:11606584ECO:0000314 direct assay evidence used in manual assertion

When two additional peptides incorporating either the Y753F (peptide 2) or Y759F (peptide 3) mutation were used, it was shown that Tyr753 was phosphorylated in preference to Tyr759 (Fig. 6 B).

challenge
unacceptableHUMAN:CIB1Grolfe, Team Pancakes At Nite2014-01-28 18:52:49 CSTGO:0005515 protein binding (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 6A-D presents results suggesting that CIB1 is a regulatory subunit of Plk3.

challenge
unacceptableHUMAN:CIB1Grolfe, Team Pancakes At Nite2014-01-28 18:32:00 CSTGO:0051592 response to calcium ion (P)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 5A-C shows that calcium-bound CIB1 inhibits Plk3 kinase activity and an absence of calcium to bind to CIB1 prevents CIB1 from inhibiting Plk3 kinase activity.

challenge
unacceptableHUMAN:CIB1Grolfe, Team Pancakes At Nite2014-01-28 18:05:02 CSTGO:0005515 protein binding (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 4A-C proves that the interaction of CIB1 and Plk3 to bind to each other is independent of the presence or absence of intracellular calcium.

challenge
updatedbyinstructorHUMAN:CIB1Grolfe, Team Pancakes At Nite2014-01-28 17:16:13 CSTGO:0008427 calcium-dependent protein kinase inhibitor activity (F)PMID:20473878ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5

challenge
unacceptableHUMAN:CIB1Grolfe, Team Pancakes At Nite2014-01-28 17:11:38 CSTGO:0008427 calcium-dependent protein kinase inhibitor activity (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows CIB1 inhibits Plk3 kinase activity.

challenge
unacceptableHUMAN:CIB1Grolfe, Team Pancakes At Nite2014-01-28 16:31:21 CSTGO:0050685 positive regulation of mRNA processing (P)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 1A-C presents results suggesting that CIB1 mRNA expression is upregulated in breast cancer tissue.

challenge

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