HUMAN:ANGI

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ANG (synonyms: RNASE5)
Protein Name(s)	Angiogenin Ribonuclease 5 RNase 5
External Links
UniProt	P03950
EMBL	M11567 AF449647 AF449648 AF449649 AF449650 AF449651 FJ236304 CR407633 AK313989 CH471078 CH471078 BC020704 BC054880 BC062698
CCDS	CCDS9554.1
PIR	A90498
RefSeq	NP_001091046.1 NP_001136.1
UniGene	Hs.283749
PDB	1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36
PDBsum	1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36
ProteinModelPortal	P03950
SMR	P03950
BioGrid	106780
IntAct	P03950
STRING	9606.ENSP00000336762
BindingDB	P03950
ChEMBL	CHEMBL5829
PhosphoSite	P03950
DMDM	113873
PaxDb	P03950
PeptideAtlas	P03950
PRIDE	P03950
DNASU	283
Ensembl	ENST00000336811 ENST00000397990
GeneID	283
KEGG	hsa:283
UCSC	uc001vxw.4
CTD	283
GeneCards	GC14P021152
GeneReviews	ANG
HGNC	HGNC:483
MIM	105850 611895
neXtProt	NX_P03950
Orphanet	803
PharmGKB	PA24790
eggNOG	NOG283332
HOGENOM	HOG000276883
HOVERGEN	HBG008396
InParanoid	P03950
KO	K16631
OMA	PCKYRAT
OrthoDB	EOG7J1826
PhylomeDB	P03950
TreeFam	TF333393
EvolutionaryTrace	P03950
GeneWiki	Angiogenin
GenomeRNAi	283
NextBio	1141
PRO	PR:P03950
Proteomes	UP000005640
Bgee	P03950
CleanEx	HS_ANG
ExpressionAtlas	P03950
Genevestigator	P03950
GO	GO:0032311 GO:0005605 GO:0005615 GO:0070062 GO:0030426 GO:0043025 GO:0005730 GO:0005634 GO:0003779 GO:0005507 GO:0003677 GO:0004519 GO:0008201 GO:0042277 GO:0005102 GO:0004540 GO:0019843 GO:0030041 GO:0032431 GO:0007202 GO:0032148 GO:0001525 GO:0007154 GO:0016477 GO:0006651 GO:0042592 GO:0048662 GO:0017148 GO:0090305 GO:0001556 GO:0001541 GO:0001890 GO:0001938 GO:0042327 GO:0050714 GO:0009725 GO:0001666 GO:0090501 GO:0009303
Gene3D	3.10.130.10
InterPro	IPR001427 IPR023411 IPR023412
PANTHER	PTHR11437
Pfam	PF00074
PRINTS	PR00794
ProDom	PD000535
SMART	SM00092
SUPFAM	SSF54076
PROSITE	PS00127

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005730	nucleolus	PMID:24356419^[1]	ECO:0000314			C	Figure 2A provides data confirming that ANG is in the nucleus of Hela cells.	complete CACAO 9468
part_of	GO:0005634	nucleus	PMID:25372031^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:25372031^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	PMID:2646638^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10152	P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:10103013^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21570	C	Seeded From UniProt	complete
involved_in	GO:0042592	homeostatic process	PMID:15166501^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:17125737^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042277	peptide binding	PMID:11782452^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032431	activation of phospholipase A2 activity	PMID:2646638^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032311	angiogenin-PRI complex	PMID:3470787^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P13489	C	Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	PMID:17125737^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21570	C	Seeded From UniProt	complete
involved_in	GO:0030041	actin filament polymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10152	P	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:17125737^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:10999833^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009303	rRNA transcription	PMID:15735021^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:10103013^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007202	activation of phospholipase C activity	PMID:2457905^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007154	cell communication	PMID:10103013^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006651	diacylglycerol biosynthetic process	PMID:2457905^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5WRG2	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10649442^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15735021^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:3663649^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16461950^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16490744^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	PMID:15166501^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:9245697^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9122172^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:2730651^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:2424496^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:7679494^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:11782452^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10649442^[12]	ECO:0000305	curator inference used in manual assertion	GO:0005634	F	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:9707554^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:9122172^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	PMID:11984825^[22]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:10999833^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:15979542^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16490744^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:15776477^[24]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001556	oocyte maturation	PMID:11438326^[25]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	PMID:12770725^[26]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:2479414^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:17125737^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004540	ribonuclease activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104984 MGI:MGI:1201793 MGI:MGI:1890463 MGI:MGI:1890464 MGI:MGI:2656551 MGI:MGI:88022 PANTHER:PTN001350296 UniProtKB:P00669 UniProtKB:P03950 UniProtKB:P07998 UniProtKB:P10152 UniProtKB:P10153 UniProtKB:P27043 UniProtKB:P30374 UniProtKB:Q93091 UniProtKB:Q9H1E1	F	Seeded From UniProt	complete
part_of	GO:0032311	angiogenin-PRI complex	PMID:3470787^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:8448182^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004519	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001427	F	Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:12548285^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019731	antibacterial humoral response	PMID:12548285^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:12548285^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:12548285^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001878	response to yeast	PMID:12548285^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019732	antifungal humoral response	PMID:12548285^[30]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019843	rRNA binding	PMID:2457905^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	PMID:10103013^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:16567967^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034332	adherens junction organization	Reactome:R-HSA-418990	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-5692437	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0652	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhu, J et al. (2013) Phospholipid scramblase 1 functionally interacts with angiogenin and regulates angiogenin-enhanced rRNA transcription. Cell. Physiol. Biochem. 32 1695-706 PubMed GONUTS page
↑ ^2.0 ^2.1 Padhi, AK et al. (2014) Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis. PLoS ONE 9 e111963 PubMed GONUTS page
↑ ^3.0 ^3.1 Bicknell, R & Vallee, BL (1989) Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2. Proc. Natl. Acad. Sci. U.S.A. 86 1573-7 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Hatzi, E & Badet, J (1999) Expression of receptors for human angiogenin in vascular smooth muscle cells. Eur. J. Biochem. 260 825-32 PubMed GONUTS page
↑ ^5.0 ^5.1 Pavlov, N et al. (2003) Angiogenin distribution in human term placenta, and expression by cultured trophoblastic cells. Angiogenesis 6 317-30 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Kim, HM et al. (2007) Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells. Biochem. Biophys. Res. Commun. 352 509-13 PubMed GONUTS page
↑ ^7.0 ^7.1 Gho, YS et al. (2002) Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin. J. Biol. Chem. 277 9690-4 PubMed GONUTS page
↑ ^8.0 ^8.1 Shapiro, R & Vallee, BL (1987) Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin. Proc. Natl. Acad. Sci. U.S.A. 84 2238-41 PubMed GONUTS page
↑ ^9.0 ^9.1 Koga, K et al. (2000) Evidence for the presence of angiogenin in human follicular fluid and the up-regulation of its production by human chorionic gonadotropin and hypoxia. J. Clin. Endocrinol. Metab. 85 3352-5 PubMed GONUTS page
↑ ^10.0 ^10.1 Tsuji, T et al. (2005) Angiogenin is translocated to the nucleus of HeLa cells and is involved in ribosomal RNA transcription and cell proliferation. Cancer Res. 65 1352-60 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Bicknell, R & Vallee, BL (1988) Angiogenin activates endothelial cell phospholipase C. Proc. Natl. Acad. Sci. U.S.A. 85 5961-5 PubMed GONUTS page
↑ ^12.0 ^12.1 Hu, Gf et al. (2000) Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA. J. Cell. Biochem. 76 452-62 PubMed GONUTS page
↑ Shapiro, R et al. (1987) Isolation of angiogenin from normal human plasma. Biochemistry 26 5141-6 PubMed GONUTS page
↑ De Ceuninck, F et al. (2005) Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome. J Biomol Tech 16 256-65 PubMed GONUTS page
↑ ^15.0 ^15.1 Nakamura, M et al. (2006) Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture. Nephrol. Dial. Transplant. 21 1489-95 PubMed GONUTS page
↑ Soncin, F et al. (1997) Interaction of human angiogenin with copper modulates angiogenin binding to endothelial cells. Biochem. Biophys. Res. Commun. 236 604-10 PubMed GONUTS page
↑ ^17.0 ^17.1 Hu, GF et al. (1997) A putative angiogenin receptor in angiogenin-responsive human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 94 2204-9 PubMed GONUTS page
↑ Lee, FS & Vallee, BL (1989) Characterization of ribonucleolytic activity of angiogenin towards tRNA. Biochem. Biophys. Res. Commun. 161 121-6 PubMed GONUTS page
↑ Shapiro, R et al. (1986) Characteristic ribonucleolytic activity of human angiogenin. Biochemistry 25 3527-32 PubMed GONUTS page
↑ Hu, GF et al. (1993) Actin is a binding protein for angiogenin. Proc. Natl. Acad. Sci. U.S.A. 90 1217-21 PubMed GONUTS page
↑ Hu, GF (1998) Neomycin inhibits angiogenin-induced angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 95 9791-5 PubMed GONUTS page
↑ Rajashekhar, G et al. (2002) Expression and localization of angiogenin in placenta: enhanced levels at term over first trimester villi. Mol. Reprod. Dev. 62 159-66 PubMed GONUTS page
↑ Rajashekhar, G et al. (2005) Hypoxia up-regulated angiogenin and down-regulated vascular cell adhesion molecule-1 expression and secretion in human placental trophoblasts. J. Soc. Gynecol. Investig. 12 310-9 PubMed GONUTS page
↑ Campo, L et al. (2005) Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival. J. Pathol. 205 585-91 PubMed GONUTS page
↑ Malamitsi-Puchner, A et al. (2001) Concentrations of angiogenic factors in follicular fluid and oocyte-cumulus complex culture medium from women undergoing in vitro fertilization: association with oocyte maturity and fertilization. Fertil. Steril. 76 98-101 PubMed GONUTS page
↑ Kawano, Y et al. (2003) Production of vascular endothelial growth factor and angiogenic factor in human follicular fluid. Mol. Cell. Endocrinol. 202 19-23 PubMed GONUTS page
↑ Shapiro, R & Vallee, BL (1989) Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis. Biochemistry 28 7401-8 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Bond, MD et al. (1993) Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim. Biophys. Acta 1162 177-86 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Hooper, LV et al. (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4 269-73 PubMed GONUTS page
↑ Song, J et al. (2006) Influence of angiogenin on the growth of A375 human melanoma cells and the expression of basic fibroblast growth factor. Melanoma Res. 16 119-26 PubMed GONUTS page

[PMID:24356419-1] Zhu, J et al. (2013) Phospholipid scramblase 1 functionally interacts with angiogenin and regulates angiogenin-enhanced rRNA transcription. Cell. Physiol. Biochem. 32 1695-706 PubMed GONUTS page

[PMID:25372031-2] 2.0 ^2.1 Padhi, AK et al. (2014) Computational and functional characterization of Angiogenin mutations, and correlation with amyotrophic lateral sclerosis. PLoS ONE 9 e111963 PubMed GONUTS page

[PMID:2646638-3] 3.0 ^3.1 Bicknell, R & Vallee, BL (1989) Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2. Proc. Natl. Acad. Sci. U.S.A. 86 1573-7 PubMed GONUTS page

[PMID:10103013-4] 4.0 ^4.1 ^4.2 ^4.3 Hatzi, E & Badet, J (1999) Expression of receptors for human angiogenin in vascular smooth muscle cells. Eur. J. Biochem. 260 825-32 PubMed GONUTS page

[PMID:15166501-5] 5.0 ^5.1 Pavlov, N et al. (2003) Angiogenin distribution in human term placenta, and expression by cultured trophoblastic cells. Angiogenesis 6 317-30 PubMed GONUTS page

[PMID:17125737-6] 6.0 ^6.1 ^6.2 ^6.3 Kim, HM et al. (2007) Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells. Biochem. Biophys. Res. Commun. 352 509-13 PubMed GONUTS page

[PMID:11782452-7] 7.0 ^7.1 Gho, YS et al. (2002) Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin. J. Biol. Chem. 277 9690-4 PubMed GONUTS page

[PMID:3470787-8] 8.0 ^8.1 Shapiro, R & Vallee, BL (1987) Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin. Proc. Natl. Acad. Sci. U.S.A. 84 2238-41 PubMed GONUTS page

[PMID:10999833-9] 9.0 ^9.1 Koga, K et al. (2000) Evidence for the presence of angiogenin in human follicular fluid and the up-regulation of its production by human chorionic gonadotropin and hypoxia. J. Clin. Endocrinol. Metab. 85 3352-5 PubMed GONUTS page

[PMID:15735021-10] 10.0 ^10.1 Tsuji, T et al. (2005) Angiogenin is translocated to the nucleus of HeLa cells and is involved in ribosomal RNA transcription and cell proliferation. Cancer Res. 65 1352-60 PubMed GONUTS page

[PMID:2457905-11] 11.0 ^11.1 ^11.2 Bicknell, R & Vallee, BL (1988) Angiogenin activates endothelial cell phospholipase C. Proc. Natl. Acad. Sci. U.S.A. 85 5961-5 PubMed GONUTS page

[PMID:10649442-12] 12.0 ^12.1 Hu, Gf et al. (2000) Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA. J. Cell. Biochem. 76 452-62 PubMed GONUTS page

[PMID:3663649-13] Shapiro, R et al. (1987) Isolation of angiogenin from normal human plasma. Biochemistry 26 5141-6 PubMed GONUTS page

[PMID:16461950-14] De Ceuninck, F et al. (2005) Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome. J Biomol Tech 16 256-65 PubMed GONUTS page

[PMID:16490744-15] 15.0 ^15.1 Nakamura, M et al. (2006) Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture. Nephrol. Dial. Transplant. 21 1489-95 PubMed GONUTS page

[PMID:9245697-16] Soncin, F et al. (1997) Interaction of human angiogenin with copper modulates angiogenin binding to endothelial cells. Biochem. Biophys. Res. Commun. 236 604-10 PubMed GONUTS page

[PMID:9122172-17] 17.0 ^17.1 Hu, GF et al. (1997) A putative angiogenin receptor in angiogenin-responsive human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 94 2204-9 PubMed GONUTS page

[PMID:2730651-18] Lee, FS & Vallee, BL (1989) Characterization of ribonucleolytic activity of angiogenin towards tRNA. Biochem. Biophys. Res. Commun. 161 121-6 PubMed GONUTS page

[PMID:2424496-19] Shapiro, R et al. (1986) Characteristic ribonucleolytic activity of human angiogenin. Biochemistry 25 3527-32 PubMed GONUTS page

[PMID:7679494-20] Hu, GF et al. (1993) Actin is a binding protein for angiogenin. Proc. Natl. Acad. Sci. U.S.A. 90 1217-21 PubMed GONUTS page

[PMID:9707554-21] Hu, GF (1998) Neomycin inhibits angiogenin-induced angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 95 9791-5 PubMed GONUTS page

[PMID:11984825-22] Rajashekhar, G et al. (2002) Expression and localization of angiogenin in placenta: enhanced levels at term over first trimester villi. Mol. Reprod. Dev. 62 159-66 PubMed GONUTS page

[PMID:15979542-23] Rajashekhar, G et al. (2005) Hypoxia up-regulated angiogenin and down-regulated vascular cell adhesion molecule-1 expression and secretion in human placental trophoblasts. J. Soc. Gynecol. Investig. 12 310-9 PubMed GONUTS page

[PMID:15776477-24] Campo, L et al. (2005) Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival. J. Pathol. 205 585-91 PubMed GONUTS page

[PMID:11438326-25] Malamitsi-Puchner, A et al. (2001) Concentrations of angiogenic factors in follicular fluid and oocyte-cumulus complex culture medium from women undergoing in vitro fertilization: association with oocyte maturity and fertilization. Fertil. Steril. 76 98-101 PubMed GONUTS page

[PMID:12770725-26] Kawano, Y et al. (2003) Production of vascular endothelial growth factor and angiogenic factor in human follicular fluid. Mol. Cell. Endocrinol. 202 19-23 PubMed GONUTS page

[PMID:2479414-27] Shapiro, R & Vallee, BL (1989) Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis. Biochemistry 28 7401-8 PubMed GONUTS page

[PMID:21873635-28] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8448182-29] Bond, MD et al. (1993) Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions. Biochim. Biophys. Acta 1162 177-86 PubMed GONUTS page

[PMID:12548285-30] 30.0 ^30.1 ^30.2 ^30.3 ^30.4 ^30.5 Hooper, LV et al. (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4 269-73 PubMed GONUTS page

[PMID:16567967-31] Song, J et al. (2006) Influence of angiogenin on the growth of A375 human melanoma cells and the expression of basic fibroblast growth factor. Melanoma Res. 16 119-26 PubMed GONUTS page

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HUMAN:ANGI

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