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PMID:17125737

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Citation

Kim, HM, Kang, DK, Kim, HY, Kang, SS and Chang, SI (2007) Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells. Biochem. Biophys. Res. Commun. 352:509-13

Abstract

Angiogenin, a potent angiogenic factor, binds to endothelial cells and is endocytosed and rapidly translocated to and concentrated in the nucleolus where it binds to DNA. In this study, we report that angiogenin induces transient phosphorylation of protein kinase B/Akt in cultured human umbilical vein endothelial (HUVE) cells. LY294002 inhibits the angiogenin-induced protein kinase B/Akt activation and also angiogenin-induced cell migration in vitro as well as angiogenesis in chick embryo chorioallantoic membrane in vivo without affecting nuclear translocation of angiogenin in HUVE cells. These results suggest that cross-talk between angiogenin and protein kinase B/Akt signaling pathways is essential for angiogenin-induced angiogenesis in vitro and in vivo, and that angiogenin-induced PKB/Akt activation is independent of nuclear translocation of angiogenin in HUVE cells.

Links

PubMed Online version:10.1016/j.bbrc.2006.11.047

Keywords

Active Transport, Cell Nucleus/physiology; Cell Nucleus/metabolism; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Humans; Neovascularization, Physiologic/physiology; Oncogene Protein v-akt/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Ribonuclease, Pancreatic/administration & dosage; Ribonuclease, Pancreatic/metabolism; Umbilical Cord/cytology; Umbilical Cord/drug effects; Umbilical Cord/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:ANGI

involved_in

GO:0001525: angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ANGI

involved_in

GO:0042327: positive regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ANGI

involved_in

GO:0032148: activation of protein kinase B activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ANGI

involved_in

GO:0016477: cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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