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PMID:12548285

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Citation

Hooper, LV, Stappenbeck, TS, Hong, CV and Gordon, JI (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 4:269-73

Abstract

Although angiogenins have been implicated in tumor-associated angiogenesis, their normal physiologic function remains unclear. We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against intestinal microbes. Ang4 expression is induced by Bacteroides thetaiotaomicron, a predominant member of the gut microflora, revealing a mechanism whereby intestinal commensal bacteria influence gut microbial ecology and shape innate immunity. Furthermore, mouse Ang1 and human angiogenin, circulating proteins induced during inflammation, exhibit microbicidal activity against systemic bacterial and fungal pathogens, suggesting that they contribute to systemic responses to infection. These results establish angiogenins as a family of endogenous antimicrobial proteins.

Links

PubMed Online version:10.1038/ni888

Keywords

Animals; Bacteroides/immunology; Humans; Immunity, Innate/physiology; Mice; Molecular Sequence Data; Organ Specificity; Paneth Cells/physiology; Paneth Cells/secretion; Ribonuclease, Pancreatic/immunology; Ribonuclease, Pancreatic/physiology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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References

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