HUMAN:FOXO1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOXO1 (synonyms: FKHR, FOXO1A)
Protein Name(s)	Forkhead box protein O1 Forkhead box protein O1A Forkhead in rhabdomyosarcoma
External Links
UniProt	Q12778
EMBL	U02310 AF032885 BT007455 AL355132 AL133318 AL133318 AL355132 BC021981 BC070065
CCDS	CCDS9371.1
PIR	S40521
RefSeq	NP_002006.2
UniGene	Hs.370666
PDB	3CO6 3CO7 3COA 4LG0
PDBsum	3CO6 3CO7 3COA 4LG0
ProteinModelPortal	Q12778
SMR	Q12778
BioGrid	108597
DIP	DIP-35654N
IntAct	Q12778
STRING	9606.ENSP00000368880
BindingDB	Q12778
ChEMBL	CHEMBL5294
PhosphoSite	Q12778
DMDM	116241368
MaxQB	Q12778
PaxDb	Q12778
PRIDE	Q12778
DNASU	2308
Ensembl	ENST00000379561
GeneID	2308
KEGG	hsa:2308
UCSC	uc001uxl.4
CTD	2308
GeneCards	GC13M041129
HGNC	HGNC:3819
HPA	CAB022326 HPA001252
MIM	136533 268220
neXtProt	NX_Q12778
Orphanet	99756
PharmGKB	PA28237
eggNOG	COG5025
GeneTree	ENSGT00390000000589
HOGENOM	HOG000251635
HOVERGEN	HBG057789
InParanoid	Q12778
KO	K07201
OMA	DSLDFNF
OrthoDB	EOG7SJD45
PhylomeDB	Q12778
TreeFam	TF315583
Reactome	REACT_12442 REACT_13655 REACT_13819 REACT_147727
SignaLink	Q12778
ChiTaRS	FOXO1
EvolutionaryTrace	Q12778
GeneWiki	FOXO1
GenomeRNAi	2308
NextBio	9375
PRO	PR:Q12778
Proteomes	UP000005640
Bgee	Q12778
CleanEx	HS_FOXO1
Genevestigator	Q12778
GO	GO:0005737 GO:0005829 GO:0005739 GO:0005654 GO:0005634 GO:0003682 GO:0051721 GO:0001078 GO:0043565 GO:0000989 GO:0031625 GO:0006915 GO:0006914 GO:0001568 GO:0001678 GO:0070417 GO:0006974 GO:0071455 GO:0032869 GO:0071732 GO:0034599 GO:0009267 GO:0031018 GO:0007173 GO:0045444 GO:0038095 GO:0008543 GO:0045087 GO:0008286 GO:0043066 GO:0045599 GO:0032873 GO:0045892 GO:0048011 GO:0048015 GO:0043065 GO:0010508 GO:0045722 GO:0045732 GO:0045944 GO:0045893 GO:0006473 GO:0042127 GO:2000505 GO:0035947 GO:0001659
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043276	anoikis	PMID:21487105^[1]	ECO:0000314			P		Figure 3 describes various assays performed to measure FOXO1 expression and activity. Figure 3D shows that when FOXO1 is expressed in prostate cancer cells, it blocks the cells' ability to form colonies in a colony-forming assay due to lack of cell-cell interactions/adhesion. Figure 3E/F show that when FOXO1 is knocked-down, ER ligands can no longer signal apoptosis, suggesting that the FOXO1 gene product is involved in apoptosis upon loss of cell adhesion.	complete
	GO:0005634	nucleus	PMID:18079193^[2]	ECO:0000314			C		Figure 1A shows staining of C2C12 cells expressing FoxO1-3A-ER. The cells were immunostained using anti-ER and DAPI nuclear staining. The control showed some overlap of areas showing staining for FoxO1-3A-ER and DAPI(nuclear stain), but when the cells were treated with 4-HT, there was more overlap of FoxO1-3A-ER and DAPI stained areas. This suggests after treatment with 4-HT, FoxO1-3A-ER was located in the nucleus.	complete CACAO 9240
	GO:0048523	negative regulation of cellular process	PMID:18079193^[2]	ECO:0000314			P		Figure 2A shows the effect on the production of raptor by the FOX01 when exposed to 4-HT versus when not. The figure shows that over time the production of raptor decreased when exposed to 4-HT versus not.	complete CACAO 9469
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001766	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61660	F		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G3V7R4	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:15905404^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032873	negative regulation of stress-activated MAPK cascade	PMID:19696738^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
involved_in	GO:0071732	cellular response to nitric oxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1E0	P		Seeded From UniProt	complete
involved_in	GO:0071455	cellular response to hyperoxia	PMID:20543840^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070417	cellular response to cold	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1E0	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10871843^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:27577745^[9]	ECO:0000315			P		Figure 6C and D show that shRNA-mediated knockdown of FOXO1 decrease expression of MARCH1. Figure 6G shows that, while insulin is absent, FOXO1 binds to the MARCH1 promoter, and while insulin is present, FOXO1 binding is inhibited.	complete CACAO 12112
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12228231^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:7862145^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10871843^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12228231^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:20543840^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1E0	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A4L7N3	P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12228231^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10871843^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:20543840^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1E0	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1E0	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:20543840^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95352	F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:20543840^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:20543840^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:A4L7N3	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1E0	P		Seeded From UniProt	complete
involved_in	GO:0006473	protein acetylation	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20543840^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11237865^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12228231^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11311120^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20543840^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18680538^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12228231^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11311120^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	F		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	PMID:22510882^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DJI6	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:1891915 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN000215135 UniProtKB:A4L7N3 UniProtKB:P98177 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN002908599 UniProtKB:P98177	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1NNE8 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 WB:WBGene00000912	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2676586 PANTHER:PTN002908599	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002908599 UniProtKB:O43524 WB:WBGene00000912 ZFIN:ZDB-GENE-990708-6	P		Seeded From UniProt	complete
involved_in	GO:1903243	negative regulation of cardiac muscle hypertrophy in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:1902617	response to fluoride	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0070166	enamel mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	F		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	F		Seeded From UniProt	complete
enables	GO:0001223	transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V7R4 ensembl:ENSRNOP00000018244	F		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:2000177	regulation of neural precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0097150	neuronal stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0071732	cellular response to nitric oxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0045722	positive regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0035947	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	F		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R1E0 ensembl:ENSMUSP00000055308	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	Reactome:R-HSA-210745	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9614423 Reactome:R-HSA-9614414 Reactome:R-HSA-211178	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9625758 Reactome:R-NUL-9625492 Reactome:R-NUL-9624599 Reactome:R-NUL-9620857 Reactome:R-NUL-9620806 Reactome:R-HSA-9626928 Reactome:R-HSA-9625091 Reactome:R-HSA-9624976 Reactome:R-HSA-9623415 Reactome:R-HSA-9622980 Reactome:R-HSA-9617996 Reactome:R-HSA-9617840 Reactome:R-HSA-9614662 Reactome:R-HSA-9614414 Reactome:R-HSA-6790036 Reactome:R-HSA-5692785 Reactome:R-HSA-5692779 Reactome:R-HSA-2399992 Reactome:R-HSA-211178 Reactome:R-HSA-211164 Reactome:R-HSA-199299	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page
↑ ^2.0 ^2.1 Wu, AL et al. (2008) Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology 149 1407-14 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page
↑ Park, HJ et al. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 28 2908-18 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Nakae, J et al. (2012) Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J. 31 2275-95 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Zhao, Y et al. (2010) Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12 665-75 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Margue, CM et al. (2000) Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene 19 2921-9 PubMed GONUTS page
↑ Nagarajan, A et al. (2016) MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun 7 12639 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Zhang, X et al. (2002) Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277 45276-84 PubMed GONUTS page
↑ Fredericks, WJ et al. (1995) The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol. Cell. Biol. 15 1522-35 PubMed GONUTS page
↑ Rena, G et al. (2001) Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem. J. 354 605-12 PubMed GONUTS page
↑ ^13.0 ^13.1 Woods, YL et al. (2001) The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem. J. 355 597-607 PubMed GONUTS page
↑ Ganopolsky, JG et al. (2008) GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. J. Thromb. Haemost. 6 1804-11 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 ^15.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21487105-1] Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page

[PMID:18079193-2] 2.0 ^2.1 Wu, AL et al. (2008) Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology 149 1407-14 PubMed GONUTS page

[PMID:19274049-3] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:15905404-4] Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page

[PMID:19696738-5] Park, HJ et al. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 28 2908-18 PubMed GONUTS page

[PMID:22510882-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 Nakae, J et al. (2012) Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J. 31 2275-95 PubMed GONUTS page

[PMID:20543840-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Zhao, Y et al. (2010) Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12 665-75 PubMed GONUTS page

[PMID:10871843-8] 8.0 ^8.1 ^8.2 Margue, CM et al. (2000) Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene 19 2921-9 PubMed GONUTS page

[PMID:27577745-9] Nagarajan, A et al. (2016) MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun 7 12639 PubMed GONUTS page

[PMID:12228231-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Zhang, X et al. (2002) Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277 45276-84 PubMed GONUTS page

[PMID:7862145-11] Fredericks, WJ et al. (1995) The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol. Cell. Biol. 15 1522-35 PubMed GONUTS page

[PMID:11237865-12] Rena, G et al. (2001) Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem. J. 354 605-12 PubMed GONUTS page

[PMID:11311120-13] 13.0 ^13.1 Woods, YL et al. (2001) The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem. J. 355 597-607 PubMed GONUTS page

[PMID:18680538-14] Ganopolsky, JG et al. (2008) GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. J. Thromb. Haemost. 6 1804-11 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 ^15.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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