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PMID:18680538

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Citation

Ganopolsky, JG, Abid, MR, Aird, WC and Blostein, MD (2008) GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. J. Thromb. Haemost. 6:1804-11

Abstract

Growth Arrest Specific gene product 6 (gas6) is a gamma-carboxylated protein that protects endothelial cells against apoptosis. Gas6 has previously been shown to induce phospatidyl-3-inositol-kinase (PI3K)/Akt signaling. Other studies have demonstrated a link between PI3K/Akt signaling and forkhead transcription factors in endothelial cells.

Links

PubMed Online version:10.1111/j.1538-7836.2008.03114.x

Keywords

Active Transport, Cell Nucleus; Cell Survival; Cyclin-Dependent Kinase Inhibitor p27/genetics; Down-Regulation/genetics; Endothelial Cells/metabolism; Forkhead Transcription Factors/metabolism; Humans; Intercellular Signaling Peptides and Proteins/pharmacology; Kinetics; Phosphatidylinositol 3-Kinases; Phosphorylation; Signal Transduction; Transcription, Genetic; Umbilical Veins/cytology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:FOXO1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0002618)

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0018105: peptidyl-serine phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P31749)|has_input:(UniProtKB:Q12778)|happens_during(GO:0043491)

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0007165: signal transduction

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:2000352: negative regulation of endothelial cell apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0051897: positive regulation of protein kinase B signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0046827: positive regulation of protein export from nucleus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P46527)

Seeded From UniProt

complete

HUMAN:GAS6

involved_in

GO:0043433: negative regulation of DNA-binding transcription factor activity

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:Q12778)

Seeded From UniProt

complete

HUMAN:FOXO1

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0002618)

Seeded From UniProt

complete

See also

References

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