HUMAN:FAK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTK2B (synonyms: FAK2, PYK2, RAFTK)
Protein Name(s)	Protein-tyrosine kinase 2-beta Calcium-dependent tyrosine kinase CADTK Calcium-regulated non-receptor proline-rich tyrosine kinase Cell adhesion kinase beta CAK-beta CAKB Focal adhesion kinase 2 FADK 2 Proline-rich tyrosine kinase 2 Related adhesion focal tyrosine kinase RAFTK
External Links
UniProt	Q14289
EMBL	U33284 L49207 D45853 U43522 S80542 AF311103 CH471080 CH471080 CH471080 BC036651 BC042599
CCDS	CCDS6057.1 CCDS6058.1
PIR	S60248
RefSeq	NP_004094.3 NP_775266.1 NP_775267.1 NP_775268.1 XP_005273504.1
UniGene	Hs.491322 Hs.735450
PDB	2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32
PDBsum	2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32
ProteinModelPortal	Q14289
SMR	Q14289
BioGrid	108480
IntAct	Q14289
MINT	MINT-1211326
STRING	9606.ENSP00000332816
BindingDB	Q14289
ChEMBL	CHEMBL5469
DrugBank	DB01097
GuidetoPHARMACOLOGY	2181
PhosphoSite	Q14289
DMDM	3183003
MaxQB	Q14289
PaxDb	Q14289
PRIDE	Q14289
DNASU	2185
Ensembl	ENST00000346049 ENST00000397501 ENST00000420218 ENST00000517339
GeneID	2185
KEGG	hsa:2185
UCSC	uc003xfn.2 uc003xfq.2
CTD	2185
GeneCards	GC08P027224
H-InvDB	HIX0168898
HGNC	HGNC:9612
HPA	CAB003850 HPA026091 HPA026276
MIM	601212
neXtProt	NX_Q14289
PharmGKB	PA33956
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000069938
HOVERGEN	HBG004018
InParanoid	Q14289
KO	K05871
OMA	VKTCKKD
OrthoDB	EOG7ZSHSB
PhylomeDB	Q14289
TreeFam	TF316643
BRENDA	2.7.10.2
Reactome	REACT_228166 REACT_23916 REACT_27283
SignaLink	Q14289
ChiTaRS	PTK2B
EvolutionaryTrace	Q14289
GeneWiki	PTK2B
GenomeRNAi	2185
NextBio	8821
PRO	PR:Q14289
Proteomes	UP000005640
Bgee	Q14289
CleanEx	HS_PTK2B
ExpressionAtlas	Q14289
Genevestigator	Q14289
GO	GO:0097440 GO:0030424 GO:0044297 GO:0005938 GO:0005737 GO:0005829 GO:0030425 GO:0005925 GO:0030426 GO:0030027 GO:0045121 GO:0017146 GO:0043025 GO:0005634 GO:0048471 GO:0014069 GO:0005524 GO:0004683 GO:0004972 GO:0004715 GO:0004713 GO:0004871 GO:0042976 GO:0032863 GO:0006915 GO:0043534 GO:0045453 GO:0007166 GO:0006968 GO:0071300 GO:0070098 GO:0007173 GO:0048041 GO:0014009 GO:0007229 GO:0035235 GO:0060291 GO:0000165 GO:0002315 GO:0043066 GO:0030502 GO:0008285 GO:0010656 GO:0045638 GO:0043524 GO:0043267 GO:0031175 GO:0001556 GO:0038083 GO:0018108 GO:0030838 GO:2000538 GO:0030307 GO:0030335 GO:0008284 GO:0001954 GO:0007204 GO:0010595 GO:0070374 GO:2000463 GO:0046330 GO:0043507 GO:0010976 GO:0050731 GO:0043552 GO:0045860 GO:2000379 GO:0051968 GO:0045727 GO:0046777 GO:0006461 GO:0006468 GO:2000249 GO:0030155 GO:0008360 GO:2000114 GO:0032960 GO:0010758 GO:2000310 GO:2000058 GO:0051279 GO:0051592 GO:0051591 GO:0042220 GO:0042493 GO:0045471 GO:0009749 GO:0009725 GO:0042542 GO:0001666 GO:0035902 GO:0010226 GO:0009612 GO:0006970 GO:0006950 GO:0007172 GO:0007165 GO:0002040 GO:0043149 GO:0033209 GO:0048010
Gene3D	1.20.80.10
InterPro	IPR019749 IPR014352 IPR019748 IPR000299 IPR005189 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR029071
Pfam	PF00373 PF03623 PF07714
PRINTS	PR00109
ProDom	PD006413
SMART	SM00295 SM00219
SUPFAM	SSF47031 SSF54236 SSF56112 SSF68993
PROSITE	PS50057 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:9545257^[1]	ECO:0000314			P		Figure 5	complete CACAO 9303
	GO:0033673	negative regulation of kinase activity	PMID:18339875^[2]	ECO:0000314			P		Figure 2 shows that after treatment with PF-562,271 more cells that were treated with 1.1 micro mole/L were in S and G2-M phase than other cells.	complete CACAO 9304
enables	GO:0008022	protein C-terminus binding	PMID:10022914^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:O00562)\|has_direct_input:(UniProtKB:Q9BZ72)\|has_direct_input:(UniProtKB:Q9BZ71)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10022914^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:O00562)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10518561^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9ULZ2)	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:10518561^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q9ULZ2)	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:10518561^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:9545257^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	C		Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	P		Seeded From UniProt	complete
contributes_to	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70600	F		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:17910947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21245381^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21245381^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:17910947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:21245381^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000538	positive regulation of B cell chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	PMID:19880522^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:7544443^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0051279	regulation of release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:18765415^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	PMID:8670418^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:7544443^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045638	negative regulation of myeloid cell differentiation	PMID:15050747^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0043267	negative regulation of potassium ion transport	PMID:7544443^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:19880522^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042976	activation of Janus kinase activity	PMID:8670418^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:8670418^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032960	regulation of inositol trisphosphate biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	PMID:18765415^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:18765415^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:19086031^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:18765415^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:7544443^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010758	regulation of macrophage chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:19086031^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:15050747^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18765415^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:15050747^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:8849729^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:18765415^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19880522^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:7544443^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002315	marginal zone B cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVP9	P		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	PMID:18765415^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700474 RGD:3443 RGD:628758	C		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87859 PANTHER:PTN001975310 UniProtKB:Q05397	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001975310 RGD:628758 UniProtKB:P00519 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231249 UniProtKB:Q14289	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001975310 RGD:628758	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231249 RGD:628758	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN002400754 RGD:3443 RGD:628758 UniProtKB:Q00944 UniProtKB:Q05397 UniProtKB:Q14289	C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000017 MGI:MGI:104908 MGI:MGI:1930958 MGI:MGI:95481 PANTHER:PTN001975310 UniProtKB:P00519 UniProtKB:Q05397 UniProtKB:Q14289 WB:WBGene00002213	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95481 PANTHER:PTN001231249 RGD:628758	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12771146^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0060292	long-term synaptic depression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0048041	focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	F		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0043534	blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0043507	positive regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
enables	GO:0043423	3-phosphoinositide-dependent protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0042976	activation of Janus kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0035902	response to immobilization stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	F		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
involved_in	GO:0014009	glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0010656	negative regulation of muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0010226	response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0001556	oocyte maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70600 ensembl:ENSRNOP00000031615	P		Seeded From UniProt	complete
involved_in	GO:2000538	positive regulation of B cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:2000114	regulation of establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0070098	chemokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0051279	regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0050848	regulation of calcium-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	C		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0045453	bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0045428	regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0032960	regulation of inositol trisphosphate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0010758	regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0010752	regulation of cGMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	F		Seeded From UniProt	complete
involved_in	GO:0002315	marginal zone B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVP9 ensembl:ENSMUSP00000022622	P		Seeded From UniProt	complete
involved_in	GO:0002688	regulation of leukocyte chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR020635 InterPro:IPR036137	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000299	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR036137	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR005189 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR036137	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
involved_in	GO:0007172	signal complex assembly	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005189 InterPro:IPR036137	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
involved_in	GO:0030500	regulation of bone mineralization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	C		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
involved_in	GO:2000249	regulation of actin cytoskeleton reorganization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030610	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:25707991^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(GO:0014069)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:25707991^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10867021^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007172	signal complex assembly	PMID:7529876^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7499242^[19] PMID:10867021^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10880513^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:7529876^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:10867021^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7499242^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:8497321^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8939945^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:8849729^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	Reactome:R-HSA-9020558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5218851 Reactome:R-HSA-5218836 Reactome:R-HSA-5218830 Reactome:R-HSA-508513 Reactome:R-HSA-508451 Reactome:R-HSA-391152	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Li, X et al. (1998) A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. J. Biol. Chem. 273 9361-4 PubMed GONUTS page
↑ Roberts, WG et al. (2008) Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res. 68 1935-44 PubMed GONUTS page
↑ ^3.0 ^3.1 Lev, S et al. (1999) Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol. Cell. Biol. 19 2278-88 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page
↑ ^5.0 ^5.1 Yamada, S et al. (2007) Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. Biochem. Biophys. Res. Commun. 363 926-30 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lim, ST et al. (2010) Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J. Biol. Chem. 285 1743-53 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Lev, S et al. (1995) Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 376 737-45 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Sun, CK et al. (2008) Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation. Carcinogenesis 29 2096-105 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tokiwa, G et al. (1996) Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 273 792-4 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Dylla, SJ et al. (2004) Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. Exp. Hematol. 32 365-74 PubMed GONUTS page
↑ ^12.0 ^12.1 Rufanova, VA et al. (2009) Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. J. Cell. Physiol. 219 45-56 PubMed GONUTS page
↑ ^13.0 ^13.1 Dikic, I et al. (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383 547-50 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kruljac-Letunic, A et al. (2003) The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J. Biol. Chem. 278 29560-70 PubMed GONUTS page
↑ ^16.0 ^16.1 Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Katagiri, T et al. (2000) Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402. J. Biol. Chem. 275 19645-52 PubMed GONUTS page
↑ ^18.0 ^18.1 Calalb, MB et al. (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 15 954-63 PubMed GONUTS page
↑ ^19.0 ^19.1 Avraham, S et al. (1995) Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem. 270 27742-51 PubMed GONUTS page
↑ Chauhan, D et al. (2000) SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. J. Biol. Chem. 275 27845-50 PubMed GONUTS page
↑ Manser, E et al. (1993) A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363 364-7 PubMed GONUTS page
↑ Yu, H et al. (1996) Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. J. Biol. Chem. 271 29993-8 PubMed GONUTS page

[PMID:9545257-1] 1.0 ^1.1 Li, X et al. (1998) A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. J. Biol. Chem. 273 9361-4 PubMed GONUTS page

[PMID:18339875-2] Roberts, WG et al. (2008) Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res. 68 1935-44 PubMed GONUTS page

[PMID:10022914-3] 3.0 ^3.1 Lev, S et al. (1999) Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol. Cell. Biol. 19 2278-88 PubMed GONUTS page

[PMID:10518561-4] 4.0 ^4.1 ^4.2 Ohya, K et al. (1999) Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc. Natl. Acad. Sci. U.S.A. 96 11976-81 PubMed GONUTS page

[PMID:17910947-5] 5.0 ^5.1 Yamada, S et al. (2007) Identification of twinfilin-2 as a factor involved in neurite outgrowth by RNAi-based screen. Biochem. Biophys. Res. Commun. 363 926-30 PubMed GONUTS page

[PMID:21245381-6] 6.0 ^6.1 ^6.2 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page

[PMID:19880522-7] 7.0 ^7.1 ^7.2 Lim, ST et al. (2010) Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J. Biol. Chem. 285 1743-53 PubMed GONUTS page

[PMID:7544443-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Lev, S et al. (1995) Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 376 737-45 PubMed GONUTS page

[PMID:18765415-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Sun, CK et al. (2008) Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation. Carcinogenesis 29 2096-105 PubMed GONUTS page

[PMID:8670418-10] 10.0 ^10.1 ^10.2 Tokiwa, G et al. (1996) Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science 273 792-4 PubMed GONUTS page

[PMID:15050747-11] 11.0 ^11.1 ^11.2 Dylla, SJ et al. (2004) Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. Exp. Hematol. 32 365-74 PubMed GONUTS page

[PMID:19086031-12] 12.0 ^12.1 Rufanova, VA et al. (2009) Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading. J. Cell. Physiol. 219 45-56 PubMed GONUTS page

[PMID:8849729-13] 13.0 ^13.1 Dikic, I et al. (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383 547-50 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12771146-15] Kruljac-Letunic, A et al. (2003) The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J. Biol. Chem. 278 29560-70 PubMed GONUTS page

[PMID:25707991-16] 16.0 ^16.1 Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page

[PMID:10867021-17] 17.0 ^17.1 ^17.2 Katagiri, T et al. (2000) Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402. J. Biol. Chem. 275 19645-52 PubMed GONUTS page

[PMID:7529876-18] 18.0 ^18.1 Calalb, MB et al. (1995) Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 15 954-63 PubMed GONUTS page

[PMID:7499242-19] 19.0 ^19.1 Avraham, S et al. (1995) Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem. 270 27742-51 PubMed GONUTS page

[PMID:10880513-20] Chauhan, D et al. (2000) SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. J. Biol. Chem. 275 27845-50 PubMed GONUTS page

[PMID:8497321-21] Manser, E et al. (1993) A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 363 364-7 PubMed GONUTS page

[PMID:8939945-22] Yu, H et al. (1996) Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. J. Biol. Chem. 271 29993-8 PubMed GONUTS page

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