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PMID:7544443

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Citation

Lev, S, Moreno, H, Martinez, R, Canoll, P, Peles, E, Musacchio, JM, Plowman, GD, Rudy, B and Schlessinger, J (1995) Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 376:737-45

Abstract

The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.

Links

PubMed Online version:10.1038/376737a0

Keywords

3T3 Cells; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Brain/enzymology; Calcium/metabolism; Cells, Cultured; Cloning, Molecular; DNA Primers; Enzyme Activation; Focal Adhesion Kinase 2; GRB2 Adaptor Protein; GTP-Binding Proteins/metabolism; Humans; Ion Channels/metabolism; Kv1.2 Potassium Channel; Mice; Molecular Sequence Data; PC12 Cells; Phosphorylation; Potassium Channels/metabolism; Potassium Channels, Voltage-Gated; Protein Kinase C/metabolism; Protein Kinases/metabolism; Protein-Tyrosine Kinases/drug effects; Protein-Tyrosine Kinases/metabolism; Proteins/metabolism; Rats; Tyrosine/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:FAK2

enables

GO:0004715: non-membrane spanning protein tyrosine kinase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:FAK2

involved_in

GO:0018108: peptidyl-tyrosine phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FAK2

involved_in

GO:0043267: negative regulation of potassium ion transport

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FAK2

involved_in

GO:0045860: positive regulation of protein kinase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FAK2

involved_in

GO:0070374: positive regulation of ERK1 and ERK2 cascade

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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