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Category:GO:0002315 ! marginal zone B cell differentiation
name: marginal zone B cell differentiation
namespace: biological_process
def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149]
comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
synonym: "marginal zone B cell development" RELATED [GOC:add]
synonym: "marginal zone B lymphocyte differentiation" EXACT []
synonym: "marginal zone B-cell differentiation" EXACT []
synonym: "marginal zone B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation involved in immune response
AmiGO
<GOterm>GO:0002315</GOterm>
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