MOUSE:TNAP3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tnfaip3 (synonyms: Tnfip3)
Protein Name(s)	Tumor necrosis factor alpha-induced protein 3 TNF alpha-induced protein 3 Putative DNA-binding protein A20 Zinc finger protein A20
External Links
UniProt	Q60769
EMBL	U19463 AK151921
CCDS	CCDS23715.1
PIR	I49237
RefSeq	NP_033423.3 XP_006512765.1
UniGene	Mm.116683
ProteinModelPortal	Q60769
SMR	Q60769
BioGrid	204243
DIP	DIP-41120N
IntAct	Q60769
MINT	MINT-97373
STRING	10090.ENSMUSP00000101167
MEROPS	C64.003
PhosphoSite	Q60769
MaxQB	Q60769
PRIDE	Q60769
Ensembl	ENSMUST00000019997 ENSMUST00000105527
GeneID	21929
KEGG	mmu:21929
UCSC	uc007ena.3
CTD	7128
MGI	MGI:1196377
eggNOG	NOG248343
GeneTree	ENSGT00530000062989
HOGENOM	HOG000133004
HOVERGEN	HBG059260
InParanoid	Q60769
KO	K11859
OMA	CETPNCP
OrthoDB	EOG7JHM57
TreeFam	TF323312
Reactome	REACT_198532 REACT_211125
NextBio	301520
PRO	PR:Q60769
Proteomes	UP000000589
Bgee	Q60769
CleanEx	MM_TNFAIP3
ExpressionAtlas	Q60769
Genevestigator	Q60769
GO	GO:0005813 GO:0005737 GO:0070062 GO:0005764 GO:0005634 GO:0003677 GO:0019900 GO:0016874 GO:0004221 GO:0004842 GO:0004843 GO:0008270 GO:0006915 GO:0001922 GO:0070301 GO:0071222 GO:0072666 GO:0006954 GO:0002315 GO:0010507 GO:0050869 GO:2000349 GO:0060548 GO:0002677 GO:0045736 GO:2000352 GO:1902042 GO:0002632 GO:0034115 GO:0043124 GO:0050728 GO:0045824 GO:0032691 GO:0032703 GO:0032715 GO:0032088 GO:0070429 GO:0070433 GO:0031397 GO:0048662 GO:0034140 GO:0034148 GO:0032720 GO:1903364 GO:2000347 GO:0045732 GO:0016579 GO:0035871 GO:0071108 GO:0070936 GO:0070536 GO:0002634 GO:0002637 GO:0045088 GO:0002237 GO:0032495 GO:0009611 GO:0072573
InterPro	IPR003323 IPR002653
Pfam	PF02338 PF01754
SMART	SM00259
PROSITE	PS50802 PS51036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045449	regulation of transcription	PMID:21437236^[1]	ECO:0000315			1		Fig 1, Fig2. A20/Tnfaip3 induces transcriptional changes at the basal level and after liver resection.	complete
involved_in	GO:2000349	negative regulation of CD40 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:2000347	positive regulation of hepatocyte proliferation	PMID:15962316^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:15962316^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:18342009^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	PMID:18342009^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	PMID:11009421^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050869	negative regulation of B cell activation	PMID:21088135^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:21088135^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:15962316^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	PMID:21088135^[5]	ECO:0000305	curator inference used in manual assertion	GO:0001922	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:18342009^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21088135^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034148	negative regulation of toll-like receptor 5 signaling pathway	PMID:19912257^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	PMID:19252225^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034115	negative regulation of heterotypic cell-cell adhesion	PMID:18006655^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:21088135^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:18342009^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:18006655^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:21088135^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	PMID:18342009^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032691	negative regulation of interleukin-1 beta production	PMID:18006655^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	PMID:18342009^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	PMID:18342009^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:18342009^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:20501938^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:20430393^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002677	negative regulation of chronic inflammatory response	PMID:18006655^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002637	regulation of immunoglobulin production	PMID:21088135^[5]	ECO:0000305	curator inference used in manual assertion	GO:0001922	P		Seeded From UniProt	complete
involved_in	GO:0002634	regulation of germinal center formation	PMID:21088135^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002632	negative regulation of granuloma formation	PMID:18006655^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002315	marginal zone B cell differentiation	PMID:21088135^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	PMID:19912257^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001922	B-1 B cell homeostasis	PMID:21088135^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:23609450^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	PMID:23609450^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045824	negative regulation of innate immune response	PMID:23609450^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
involved_in	GO:0035871	protein K11-linked deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
involved_in	GO:1990168	protein K33-linked deubiquitination	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001001090 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:Q9UGI0	F		Seeded From UniProt	complete
involved_in	GO:0035523	protein K29-linked deubiquitination	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037734 PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332188 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196377 MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:Q6GQQ9 UniProtKB:Q9UGI0	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001001090 UniProtKB:P21580 UniProtKB:Q6GQQ9 UniProtKB:Q9UGI0	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:P21580 UniProtKB:Q6GQQ9 UniProtKB:Q8TE49 UniProtKB:Q9UGI0	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000349	negative regulation of CD40 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903364	positive regulation of cellular protein catabolic process	PMID:18952128^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072666	establishment of protein localization to vacuole	PMID:18952128^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072573	tolerance induction to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071108	protein K48-linked deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070536	protein K63-linked deubiquitination	PMID:24012418^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
enables	GO:0061578	Lys63-specific deubiquitinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050713	negative regulation of interleukin-1 beta secretion	PMID:28094437^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035871	protein K11-linked deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10385526^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002237	response to molecule of bacterial origin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21580	F		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:2000349	negative regulation of CD40 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0072573	tolerance induction to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0070936	protein K48-linked ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0050713	negative regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
involved_in	GO:0035871	protein K11-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
enables	GO:0004842	ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21580 ensembl:ENSP00000481570	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002653	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002653	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033478	P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033478	P		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Damrauer, SM et al. (2011) A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE 6 e17715 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Longo, CR et al. (2005) A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. Hepatology 42 156-64 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Hitotsumatsu, O et al. (2008) The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28 381-90 PubMed GONUTS page
↑ Lee, EG et al. (2000) Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289 2350-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Chu, Y et al. (2011) B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood 117 2227-36 PubMed GONUTS page
↑ ^6.0 ^6.1 Oshima, N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 159 185-98 PubMed GONUTS page
↑ Zeng, W et al. (2009) A20 overexpression inhibits low shear flow-induced CD14-positive monocyte recruitment to endothelial cells. Biorheology 46 21-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wolfrum, S et al. (2007) The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes. Proc. Natl. Acad. Sci. U.S.A. 104 18601-6 PubMed GONUTS page
↑ Shi, CS & Kehrl, JH (2010) TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 3 ra42 PubMed GONUTS page
↑ Damrauer, SM et al. (2010) A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis 211 404-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Li, Y et al. (2013) Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J. Biol. Chem. 288 16225-34 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Li, L et al. (2009) The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim. Biophys. Acta 1793 346-53 PubMed GONUTS page
↑ Xia, M et al. (2013) Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity 39 470-81 PubMed GONUTS page
↑ Lee, JY et al. (2017) The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein. FEBS Lett. 591 479-490 PubMed GONUTS page
↑ Heyninck, K et al. (1999) The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. 145 1471-82 PubMed GONUTS page

[PMID:21437236-1] Damrauer, SM et al. (2011) A20 modulates lipid metabolism and energy production to promote liver regeneration. PLoS ONE 6 e17715 PubMed GONUTS page

[PMID:15962316-2] 2.0 ^2.1 ^2.2 Longo, CR et al. (2005) A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. Hepatology 42 156-64 PubMed GONUTS page

[PMID:18342009-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Hitotsumatsu, O et al. (2008) The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28 381-90 PubMed GONUTS page

[PMID:11009421-4] Lee, EG et al. (2000) Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289 2350-4 PubMed GONUTS page

[PMID:21088135-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Chu, Y et al. (2011) B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood 117 2227-36 PubMed GONUTS page

[PMID:19912257-6] 6.0 ^6.1 Oshima, N et al. (2010) A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 159 185-98 PubMed GONUTS page

[PMID:19252225-7] Zeng, W et al. (2009) A20 overexpression inhibits low shear flow-induced CD14-positive monocyte recruitment to endothelial cells. Biorheology 46 21-30 PubMed GONUTS page

[PMID:18006655-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wolfrum, S et al. (2007) The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes. Proc. Natl. Acad. Sci. U.S.A. 104 18601-6 PubMed GONUTS page

[PMID:20501938-9] Shi, CS & Kehrl, JH (2010) TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 3 ra42 PubMed GONUTS page

[PMID:20430393-10] Damrauer, SM et al. (2010) A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis 211 404-8 PubMed GONUTS page

[PMID:23609450-11] 11.0 ^11.1 ^11.2 Li, Y et al. (2013) Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J. Biol. Chem. 288 16225-34 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18952128-13] 13.0 ^13.1 Li, L et al. (2009) The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim. Biophys. Acta 1793 346-53 PubMed GONUTS page

[PMID:24012418-14] Xia, M et al. (2013) Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20. Immunity 39 470-81 PubMed GONUTS page

[PMID:28094437-15] Lee, JY et al. (2017) The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein. FEBS Lett. 591 479-490 PubMed GONUTS page

[PMID:10385526-16] Heyninck, K et al. (1999) The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. J. Cell Biol. 145 1471-82 PubMed GONUTS page

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