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User:Grolfe

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CACAO Spring 2014

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableHUMAN:CIB12014-01-28 16:31:21 CSTGO:0050685 positive regulation of mRNA processing (P)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 1A-C presents results suggesting that CIB1 mRNA expression is upregulated in breast cancer tissue.

challenge
unacceptableHUMAN:CIB12014-01-28 17:11:38 CSTGO:0008427 calcium-dependent protein kinase inhibitor activity (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows CIB1 inhibits Plk3 kinase activity.

challenge
updatedbyinstructorHUMAN:CIB12014-01-28 17:16:13 CSTGO:0008427 calcium-dependent protein kinase inhibitor activity (F)PMID:20473878ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5

challenge
unacceptableHUMAN:CIB12014-01-28 18:05:02 CSTGO:0005515 protein binding (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 4A-C proves that the interaction of CIB1 and Plk3 to bind to each other is independent of the presence or absence of intracellular calcium.

challenge
unacceptableHUMAN:CIB12014-01-28 18:32:00 CSTGO:0051592 response to calcium ion (P)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 5A-C shows that calcium-bound CIB1 inhibits Plk3 kinase activity and an absence of calcium to bind to CIB1 prevents CIB1 from inhibiting Plk3 kinase activity.

challenge
unacceptableHUMAN:CIB12014-01-28 18:52:49 CSTGO:0005515 protein binding (F)PMID:20473878ECO:0000314 direct assay evidence used in manual assertion

Figure 6A-D presents results suggesting that CIB1 is a regulatory subunit of Plk3.

challenge
updatedbyinstructorHUMAN:PLS12014-01-30 19:56:39 CSTGO:0005730 nucleolus (C)PMID:24356419ECO:0000314 direct assay evidence used in manual assertion

Figure 2A-C provides data confirming that ANG is in the nucleus of Hela cells.

challenge
unacceptableHUMAN:ANGI2014-02-06 17:13:53 CSTGO:0005730 nucleolus (C)PMID:24356419ECO:0000314 direct assay evidence used in manual assertion

Figure 2A provides data confirming that ANG is in the nucleus of Hela cells.

challenge

acceptable:0
unacceptable:6
requires_changes:0
flagged:0

Annotations challenged by Grolfe

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
unacceptableBmanieri,
Team Chicken Day
YEAST:TAF14GO:0005674 - transcription factor TFIIF complex (C)PMID:7995524ECO:0000314 direct assay evidence used in manual assertionchallengeC: 2
unacceptableBmanieri,
Team Chicken Day
HUMAN:CFADGO:0003817 - obsolete complement factor D activity (F)PMID:00746ECO:0000314 direct assay evidence used in manual assertionchallengeC: 2
updatedbyinstructorTrange,
Team Kitten Me Right Meow
RAT:DNAS1GO:0004536 - DNA nuclease activity (F)PMID:8428592ECO:0000314 direct assay evidence used in manual assertionchallengeC: 3
unacceptableChong,
Team Kitten Me Right Meow
PIG:OXYRGO:0004990 - oxytocin receptor activity (F)PMID:8393786ECO:0000314 direct assay evidence used in manual assertionchallengeC: 2
unacceptableEturner,
Team BAMF
MYCTU:FABGGO:0030497 - fatty acid elongation (P)PMID:11932442ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1

0 annotations fixed by Grolfe

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