GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CACAO Spring 2014
|Status||Page||Date/Time||GO Term (Aspect)||Reference||Evidence||Notes||Links|
|RAT:DNAS1||2014-02-02 02:22:28 CST||GO:0004536 deoxyribonuclease activity (F)||PMID:8428592||ECO:0000314 direct assay evidence used in manual assertion|
|MOUSE:DNAS1||2014-02-02 02:52:14 CST||GO:0004530 deoxyribonuclease I activity (F)||PMID:15015938||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 1 has homogenous Dnase1 (+) and homogenous mutant Dnase1 (-) mice. Dnase1 activity was able to be detected in (+) mice in several tissues including stomach, pituitary, kidney, lymph, and thyroid. Double mutants had no Dnase1 activity in any of the tissues.
|HUMAN:THBG||2014-02-02 03:29:53 CST||GO:0009791 post-embryonic development (P)||PMID:22260853||ECO:0000314 direct assay evidence used in manual assertion|
The second half of Figure 2 shows the progression of thyroxine-binding globulin over time in hypothyroid women from stimulation, to post-embryonic development. It was tested between women who were treated for hypothyroidism vs. women who were not. Overall, the increase in TBG presence is gradual over time, but the increase is not statistically significant.
|HUMAN:CLCN1||2014-02-02 03:58:10 CST||GO:0005254 chloride channel activity (F)||PMID:0000037||ECO:0000314 direct assay evidence used in manual assertion|
Figure 1 depicts an RT-PCR of mRNAs of CLC-1 through CLC-7. Chloride ion flux is a necessary part of corneal wound electric current in human corneal epithelium. Chloride channel proteins 2,3,4, 5, and 6, but chloride channel 1 is not involved.
|HUMAN:CLCN1||2014-02-02 04:11:38 CST||GO:0042493 response to drug (P)||PMID:19153558||ECO:0000314 direct assay evidence used in manual assertion|
Figure 2Ac depicts the increase in chloride sensing of drug by increase in pH. The quick response of chloride ions to drug implies the possibility of chloride channel drug targeting for inhibition of disease progression.
|RAT:Q6I9B6||2014-02-02 17:52:35 CST||GO:0005267 potassium channel activity (F)||PMID:17346910||ECO:0000314 direct assay evidence used in manual assertion|
Figure 3 is a gel electrophoresis of the RT-PCR experiment of amplifying DNA of the rat cochlear nucleus. This gel electrophoresis shows that a subset of potassium channel's are expressed in the rat cochlear nucleus and present in all subdivisions of the cochlear nucleus.
|HUMAN:CDKN3||2014-02-02 18:17:48 CST||GO:0004721 phosphoprotein phosphatase activity (F)||PMID:18669648||ECO:0000314 direct assay evidence used in manual assertion|
Figure 5 B and C are entire proteome topographical plots of up-regulated phosphorylation in G1 (B) and M-phase (C) cells. M-phase cells have much more M-phase phosphoprotein phosphatase activity than G1 protein activity seen in G1 cells based on a Protein Regulated Phosphorylation (P-RePh) scores > 10.
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