GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:DNAS1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Dnase1 (synonyms: Dnl1) | |
| Protein Name(s) | Deoxyribonuclease-1
Deoxyribonuclease I DNase I | |
| External Links | ||
| UniProt | P49183 | |
| EMBL | U00478 D83038 | |
| CCDS | CCDS27913.1 | |
| PIR | JC2526 | |
| RefSeq | NP_034191.3 XP_006521837.1 XP_006521838.1 XP_006521839.1 | |
| UniGene | Mm.440565 | |
| ProteinModelPortal | P49183 | |
| SMR | P49183 | |
| IntAct | P49183 | |
| PhosphoSite | P49183 | |
| MaxQB | P49183 | |
| PaxDb | P49183 | |
| PRIDE | P49183 | |
| Ensembl | ENSMUST00000006136 ENSMUST00000120009 | |
| GeneID | 13419 | |
| KEGG | mmu:13419 | |
| UCSC | uc007xzh.1 | |
| CTD | 1773 | |
| MGI | MGI:103157 | |
| eggNOG | NOG46375 | |
| HOGENOM | HOG000059570 | |
| HOVERGEN | HBG051368 | |
| InParanoid | P49183 | |
| KO | K11994 | |
| OMA | TSTHCAY | |
| PhylomeDB | P49183 | |
| TreeFam | TF329541 | |
| BRENDA | 3.1.21.1 | |
| ChiTaRS | Dnase1 | |
| NextBio | 283827 | |
| PRO | PR:P49183 | |
| Proteomes | UP000000589 | |
| Bgee | P49183 | |
| CleanEx | MM_DNASE1 | |
| ExpressionAtlas | P49183 | |
| Genevestigator | P49183 | |
| GO | GO:0070062 GO:0005635 GO:0004530 GO:0006915 | |
| Gene3D | 3.60.10.10 | |
| InterPro | IPR018057 IPR016202 IPR005135 | |
| PANTHER | PTHR11371 | |
| Pfam | PF03372 | |
| PIRSF | PIRSF000988 | |
| PRINTS | PR00130 | |
| SMART | SM00476 | |
| SUPFAM | SSF56219 | |
| PROSITE | PS00919 PS00918 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004530 |
deoxyribonuclease I activity |
ECO:0000315 |
F |
Figure 1 has homogenous Dnase1 (+) and homogenous mutant Dnase1 (-) mice. Dnase1 activity was able to be detected in (+) mice in several tissues including stomach, pituitary, kidney, lymph, and thyroid. Double mutants had no Dnase1 activity in any of the tissues. |
complete | |||||
|
involved_in |
GO:0002283 |
neutrophil activation involved in immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070948 |
regulation of neutrophil mediated cytotoxicity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002673 |
regulation of acute inflammatory response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006308 |
DNA catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913955 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1314633 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260967 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103157 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260967 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103157 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2510 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2510 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21704 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P21704 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006308 |
DNA catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Napirei, M et al. (2004) Expression pattern of the deoxyribonuclease 1 gene: lessons from the Dnase1 knockout mouse. Biochem. J. 380 929-37 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Jiménez-Alcázar, M et al. (2017) Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358 1202-1206 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
d
e
g
n
r
