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HUMAN:THBG
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SERPINA7 (synonyms: TBG) | |
| Protein Name(s) | Thyroxine-binding globulin
Serpin A7 T4-binding globulin | |
| External Links | ||
| UniProt | P05543 | |
| EMBL | M14091 X64171 L13470 Z83850 CH471120 CH471120 BC020747 | |
| CCDS | CCDS14518.1 | |
| PIR | A47224 | |
| RefSeq | NP_000345.2 | |
| UniGene | Hs.76838 | |
| PDB | 2CEO 2RIV 2RIW 2XN3 2XN5 2XN6 2XN7 | |
| PDBsum | 2CEO 2RIV 2RIW 2XN3 2XN5 2XN6 2XN7 | |
| ProteinModelPortal | P05543 | |
| SMR | P05543 | |
| BioGrid | 112769 | |
| STRING | 9606.ENSP00000329374 | |
| ChEMBL | CHEMBL3843 | |
| DrugBank | DB00451 DB00279 DB01583 | |
| MEROPS | I04.955 | |
| PhosphoSite | P05543 | |
| DMDM | 1351236 | |
| MaxQB | P05543 | |
| PaxDb | P05543 | |
| PeptideAtlas | P05543 | |
| PRIDE | P05543 | |
| DNASU | 6906 | |
| Ensembl | ENST00000327674 ENST00000372563 | |
| GeneID | 6906 | |
| KEGG | hsa:6906 | |
| UCSC | uc004eme.2 | |
| CTD | 6906 | |
| GeneCards | GC0XM105277 | |
| HGNC | HGNC:11583 | |
| HPA | HPA002803 | |
| MIM | 314200 | |
| neXtProt | NX_P05543 | |
| Orphanet | 209893 | |
| PharmGKB | PA36347 | |
| eggNOG | COG4826 | |
| GeneTree | ENSGT00760000118839 | |
| HOGENOM | HOG000238521 | |
| HOVERGEN | HBG005957 | |
| InParanoid | P05543 | |
| OMA | FNLTDTP | |
| OrthoDB | EOG7QC7W9 | |
| PhylomeDB | P05543 | |
| TreeFam | TF343201 | |
| EvolutionaryTrace | P05543 | |
| GenomeRNAi | 6906 | |
| NextBio | 27007 | |
| PRO | PR:P05543 | |
| Proteomes | UP000005640 | |
| Bgee | P05543 | |
| CleanEx | HS_SERPINA7 | |
| Genevestigator | P05543 | |
| GO | GO:0005576 GO:0005615 GO:0070062 GO:0042562 GO:0004867 GO:0007568 GO:0010951 GO:0009791 GO:0030162 GO:0051412 GO:0042493 GO:0043434 GO:0034695 GO:0033189 GO:0070327 | |
| InterPro | IPR023795 IPR023796 IPR000215 | |
| PANTHER | PTHR11461 | |
| Pfam | PF00079 | |
| SMART | SM00093 | |
| SUPFAM | SSF56574 | |
| PROSITE | PS00284 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070327 |
thyroid hormone transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002930 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002930 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0028988 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0009791 |
post-embryonic development |
ECO:0000314 |
P |
The second half of Figure 2 shows the progression of thyroxine-binding globulin over time in hypothyroid women from stimulation, to post-embryonic development. It was tested between women who were treated for hypothyroidism vs. women who were not. Overall, the increase in TBG presence is gradual over time, but the increase is not statistically significant. |
complete | |||||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Domingues, R et al. (2009) A novel variant in Serpina7 gene in a family with thyroxine-binding globulin deficiency. Endocrine 36 83-6 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Janssen, OE et al. (1995) Molecular and structural characterization of the heat-resistant thyroxine-binding globulin-Chicago. J. Biol. Chem. 270 28234-8 PubMed GONUTS page
- ↑ Gracia, CR et al. (2012) Thyroid function during controlled ovarian hyperstimulation as part of in vitro fertilization. Fertil. Steril. 97 585-91 PubMed GONUTS page
- ↑ Flink, IL et al. (1986) Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Proc. Natl. Acad. Sci. U.S.A. 83 7708-12 PubMed GONUTS page
