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RAT:DNAS1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Dnase1 (synonyms: Dnl1)
Protein Name(s) Deoxyribonuclease-1

Deoxyribonuclease I DNase I

External Links
UniProt P21704
EMBL X56060
U76635
AF397150
AF397151
BC089764
PIR S13676
RefSeq NP_037229.1
XP_006245891.1
UniGene Rn.6077
ProteinModelPortal P21704
SMR P21704
STRING 10116.ENSRNOP00000009283
PaxDb P21704
PRIDE P21704
Ensembl ENSRNOT00000009283
GeneID 25633
KEGG rno:25633
UCSC RGD:2510
CTD 1773
RGD 2510
eggNOG NOG46375
GeneTree ENSGT00390000013146
HOGENOM HOG000059570
HOVERGEN HBG051368
InParanoid P21704
KO K11994
OMA TSTHCAY
OrthoDB EOG73V6KW
PhylomeDB P21704
TreeFam TF329541
BRENDA 3.1.21.1
NextBio 607443
PRO PR:P21704
Proteomes UP000002494
Genevestigator P21704
GO GO:0070062
GO:0005635
GO:0004530
GO:0006915
GO:0000737
Gene3D 3.60.10.10
InterPro IPR018057
IPR016202
IPR005135
PANTHER PTHR11371
Pfam PF03372
PIRSF PIRSF000988
PRINTS PR00130
SMART SM00476
SUPFAM SSF56219
PROSITE PS00919
PS00918

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004536

deoxyribonuclease activity

PMID:8428592[1]

ECO:0000314

F

Fig 4.

complete
CACAO 9411

involved_in

GO:0070948

regulation of neutrophil mediated cytotoxicity

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0002673

regulation of acute inflammatory response

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0002283

neutrophil activation involved in immune response

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:29191910[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49183

P

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

PMID:8428592[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

PMID:12005024[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103157
MGI:MGI:1314633
PANTHER:PTN000889801

P

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913955
PANTHER:PTN002260967
UniProtKB:Q9HXA4

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1314633
PANTHER:PTN000889801
RGD:620669
UniProtKB:Q13609

C

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260967
RGD:2510
UniProtKB:Q9HXA4

F

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103157
PANTHER:PTN002260967
RGD:2510

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260967
RGD:620669

F

Seeded From UniProt

complete

involved_in

GO:0070948

regulation of neutrophil mediated cytotoxicity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

F

Seeded From UniProt

complete

involved_in

GO:0002673

regulation of acute inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

involved_in

GO:0002283

neutrophil activation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

involved_in

GO:0000737

DNA catabolic process, endonucleolytic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49183
ensembl:ENSMUSP00000006136

P

Seeded From UniProt

complete

enables

GO:0004536

deoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016202

F

Seeded From UniProt

complete

involved_in

GO:0006308

DNA catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016202

P

Seeded From UniProt

complete

enables

GO:0004530

deoxyribonuclease I activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.21.1

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Peitsch, MC et al. (1993) Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12 371-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Jiménez-Alcázar, M et al. (2017) Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358 1202-1206 PubMed GONUTS page
  3. Tsutsumi, S et al. () DNase I is present in the chief cells of human and rat stomachs. Histochem. J. 33 531-5 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page