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RAT:DNAS1
Contents
| Species (Taxon ID) | Rattus norvegicus (Rat). (10116) | |
| Gene Name(s) | Dnase1 (synonyms: Dnl1) | |
| Protein Name(s) | Deoxyribonuclease-1
Deoxyribonuclease I DNase I | |
| External Links | ||
| UniProt | P21704 | |
| EMBL | X56060 U76635 AF397150 AF397151 BC089764 | |
| PIR | S13676 | |
| RefSeq | NP_037229.1 XP_006245891.1 | |
| UniGene | Rn.6077 | |
| ProteinModelPortal | P21704 | |
| SMR | P21704 | |
| STRING | 10116.ENSRNOP00000009283 | |
| PaxDb | P21704 | |
| PRIDE | P21704 | |
| Ensembl | ENSRNOT00000009283 | |
| GeneID | 25633 | |
| KEGG | rno:25633 | |
| UCSC | RGD:2510 | |
| CTD | 1773 | |
| RGD | 2510 | |
| eggNOG | NOG46375 | |
| GeneTree | ENSGT00390000013146 | |
| HOGENOM | HOG000059570 | |
| HOVERGEN | HBG051368 | |
| InParanoid | P21704 | |
| KO | K11994 | |
| OMA | TSTHCAY | |
| OrthoDB | EOG73V6KW | |
| PhylomeDB | P21704 | |
| TreeFam | TF329541 | |
| BRENDA | 3.1.21.1 | |
| NextBio | 607443 | |
| PRO | PR:P21704 | |
| Proteomes | UP000002494 | |
| Genevestigator | P21704 | |
| GO | GO:0070062 GO:0005635 GO:0004530 GO:0006915 GO:0000737 | |
| Gene3D | 3.60.10.10 | |
| InterPro | IPR018057 IPR016202 IPR005135 | |
| PANTHER | PTHR11371 | |
| Pfam | PF03372 | |
| PIRSF | PIRSF000988 | |
| PRINTS | PR00130 | |
| SMART | SM00476 | |
| SUPFAM | SSF56219 | |
| PROSITE | PS00919 PS00918 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004536 |
deoxyribonuclease activity |
ECO:0000314 |
F |
Fig 4. |
complete | |||||
|
involved_in |
GO:0070948 |
regulation of neutrophil mediated cytotoxicity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002673 |
regulation of acute inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002283 |
neutrophil activation involved in immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103157 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006308 |
DNA catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913955 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1314633 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260967 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103157 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002260967 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070948 |
regulation of neutrophil mediated cytotoxicity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49183 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49183 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002673 |
regulation of acute inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49183 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002283 |
neutrophil activation involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49183 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000737 |
DNA catabolic process, endonucleolytic |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49183 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004536 |
deoxyribonuclease activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006308 |
DNA catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004530 |
deoxyribonuclease I activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004518 |
nuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004519 |
endonuclease activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Peitsch, MC et al. (1993) Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12 371-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Jiménez-Alcázar, M et al. (2017) Host DNases prevent vascular occlusion by neutrophil extracellular traps. Science 358 1202-1206 PubMed GONUTS page
- ↑ Tsutsumi, S et al. () DNase I is present in the chief cells of human and rat stomachs. Histochem. J. 33 531-5 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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