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HUMAN:CDKN3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDKN3 (synonyms: CDI1, CIP2, KAP)
Protein Name(s) Cyclin-dependent kinase inhibitor 3

CDK2-associated dual-specificity phosphatase Cyclin-dependent kinase interactor 1 Cyclin-dependent kinase-interacting protein 2 Kinase-associated phosphatase

External Links
UniProt Q16667
EMBL U02681
L27711
AF213033
AF213036
AF213038
AF213039
AF213041
AF213042
AF213046
AF213047
AF213049
AF213053
AY257474
L25876
EF560750
CR407666
BT019451
AY194117
CH471061
CH471061
BC064965
CCDS CCDS45109.1
CCDS9716.1
PIR A49436
RefSeq NP_001124323.1
NP_005183.2
UniGene Hs.84113
PDB 1FPZ
1FQ1
PDBsum 1FPZ
1FQ1
ProteinModelPortal Q16667
SMR Q16667
BioGrid 107467
DIP DIP-24231N
DIP-245N
IntAct Q16667
MINT MINT-204916
DEPOD Q16667
PhosphoSite Q16667
DMDM 2499769
MaxQB Q16667
PaxDb Q16667
PRIDE Q16667
DNASU 1033
Ensembl ENST00000335183
ENST00000442975
GeneID 1033
KEGG hsa:1033
UCSC uc001xap.3
uc001xar.3
CTD 1033
GeneCards GC14P054863
HGNC HGNC:1791
HPA CAB005285
HPA039311
MIM 114550
123832
neXtProt NX_Q16667
PharmGKB PA26324
eggNOG COG2453
GeneTree ENSGT00390000004717
HOVERGEN HBG075798
InParanoid Q16667
KO K14167
OMA TVKQYNF
OrthoDB EOG7M0NSV
PhylomeDB Q16667
TreeFam TF101040
ChiTaRS CDKN3
EvolutionaryTrace Q16667
GeneWiki CDKN3
GenomeRNAi 1033
NextBio 4349
PRO PR:Q16667
Proteomes UP000005640
Bgee Q16667
ExpressionAtlas Q16667
Genevestigator Q16667
GO GO:0005737
GO:0048471
GO:0004722
GO:0004725
GO:0008138
GO:0007050
GO:0000082
GO:0008285
GO:0035335
GO:0000079
Gene3D 3.90.190.10
InterPro IPR008425
IPR022778
IPR029021
IPR000387
PANTHER PTHR23339:SF24
Pfam PF05706
PIRSF PIRSF037322
SUPFAM SSF52799
PROSITE PS50056

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004721

phosphoprotein phosphatase activity

PMID:18669648[1]

ECO:0000314

F

Figure 5 B and C are entire proteome topographical plots of up-regulated phosphorylation in G1 (B) and M-phase (C) cells. M-phase cells have much more M-phase phosphoprotein phosphatase activity than G1 protein activity seen in G1 cells based on a Protein Regulated Phosphorylation (P-RePh) scores > 10.

complete
CACAO 9467

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:10669749[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001155430
UniProtKB:Q16667

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0024734
PANTHER:PTN000596945
PomBase:SPAC1782.09c
SGD:S000001924
UniProtKB:O75365
UniProtKB:Q12974
UniProtKB:Q93096
WB:WBGene00000383

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000596945
RGD:61970
UniProtKB:O60729
UniProtKB:Q16667
UniProtKB:Q8IIN1

F

Seeded From UniProt

complete

enables

GO:0004722

protein serine/threonine phosphatase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001515873
UniProtKB:Q16667

F

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

PMID:8242750[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:8242750[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004722

protein serine/threonine phosphatase activity

PMID:12745075[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004721

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008138

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004722

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004722

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004721

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004721

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008425
InterPro:IPR022778

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008425
InterPro:IPR022778

F

Seeded From UniProt

complete

involved_in

GO:0016311

dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

P

Seeded From UniProt

complete

enables

GO:0016791

phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000387

F

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.16

F

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:8242750[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008138

protein tyrosine/serine/threonine phosphatase activity

PMID:8242750[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

PMID:8242750[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

PMID:8127873[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:8242750[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Dephoure, N et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 105 10762-7 PubMed GONUTS page
  2. ↑ Lee, SW et al. (2000) Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. Mol. Cell. Biol. 20 1723-32 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gyuris, J et al. (1993) Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75 791-803 PubMed GONUTS page
  5. ↑ Yeh, CT et al. (2003) Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. Biochem. Biophys. Res. Commun. 305 311-4 PubMed GONUTS page
  6. ↑ Hannon, GJ et al. (1994) KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Proc. Natl. Acad. Sci. U.S.A. 91 1731-5 PubMed GONUTS page
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