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HUMAN:CFAD
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CFD (synonyms: DF, PFD) | |
| Protein Name(s) | Complement factor D
Adipsin C3 convertase activator Properdin factor D | |
| External Links | ||
| UniProt | P00746 | |
| EMBL | AJ313463 AK300963 CH471139 BC034529 BC040146 BC051001 BC057807 M84526 | |
| CCDS | CCDS12046.1 | |
| PIR | A40197 | |
| RefSeq | NP_001919.2 | |
| UniGene | Hs.155597 | |
| PDB | 1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4CBN 4CBO 4D9R | |
| PDBsum | 1BIO 1DFP 1DIC 1DST 1DSU 1FDP 1HFD 2XW9 2XWA 2XWB 4CBN 4CBO 4D9R | |
| ProteinModelPortal | P00746 | |
| SMR | P00746 | |
| BioGrid | 108039 | |
| IntAct | P00746 | |
| STRING | 9606.ENSP00000332139 | |
| BindingDB | P00746 | |
| ChEMBL | CHEMBL2176771 | |
| MEROPS | S01.191 | |
| PhosphoSite | P00746 | |
| DMDM | 158515408 | |
| PaxDb | P00746 | |
| PRIDE | P00746 | |
| Ensembl | ENST00000327726 ENST00000617994 | |
| GeneID | 1675 | |
| KEGG | hsa:1675 | |
| UCSC | uc002lqc.3 | |
| CTD | 1675 | |
| GeneCards | GC19P000859 | |
| HGNC | HGNC:2771 | |
| HPA | CAB016383 | |
| MIM | 134350 613912 | |
| neXtProt | NX_P00746 | |
| Orphanet | 169467 | |
| PharmGKB | PA142 | |
| eggNOG | COG5640 | |
| GeneTree | ENSGT00760000118895 | |
| HOVERGEN | HBG013304 | |
| InParanoid | P00746 | |
| KO | K01334 | |
| OrthoDB | EOG7MKW6Q | |
| PhylomeDB | P00746 | |
| TreeFam | TF333630 | |
| BRENDA | 3.4.21.46 | |
| Reactome | REACT_8001 | |
| ChiTaRS | CFD | |
| EvolutionaryTrace | P00746 | |
| GenomeRNAi | 1675 | |
| NextBio | 6892 | |
| PRO | PR:P00746 | |
| Proteomes | UP000005640 UP000005640 | |
| Bgee | P00746 | |
| CleanEx | HS_CFD | |
| ExpressionAtlas | P00746 | |
| Genevestigator | P00746 | |
| GO | GO:0005576 GO:0005615 GO:0070062 GO:0031093 GO:0004252 GO:0008236 GO:0007596 GO:0006956 GO:0006957 GO:0045087 GO:0030168 GO:0002576 GO:0006508 | |
| InterPro | IPR001254 IPR018114 IPR001314 IPR009003 | |
| Pfam | PF00089 | |
| PRINTS | PR00722 | |
| SMART | SM00020 | |
| SUPFAM | SSF50494 | |
| PROSITE | PS50240 PS00134 PS00135 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
| GO:0003817 |
complement factor D activity |
PMID:P00746 |
ECO:0000314 |
F |
Figure 5 depects that overall, the tertiary structure of the S94Y/T214S/S215W mutant is very similar to that of native factor D. |
complete | ||||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001254 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006957 |
complement activation, alternative pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006956 |
complement activation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1904813 |
ficolin-1-rich granule lumen |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0034774 |
secretory granule lumen |
Reactome:R-HSA-6798748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031093 |
platelet alpha granule lumen |
Reactome:R-HSA-481007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006957 |
complement activation, alternative pathway |
Reactome:R-HSA-173736 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0002576 |
platelet degranulation |
Reactome:R-HSA-114608 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006957 |
complement activation, alternative pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 White, RT et al. (1992) Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J. Biol. Chem. 267 9210-3 PubMed GONUTS page
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