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HUMAN:CFAD

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CFD (synonyms: DF, PFD)
Protein Name(s) Complement factor D

Adipsin C3 convertase activator Properdin factor D

External Links
UniProt P00746
EMBL AJ313463
AK300963
CH471139
BC034529
BC040146
BC051001
BC057807
M84526
CCDS CCDS12046.1
PIR A40197
RefSeq NP_001919.2
UniGene Hs.155597
PDB 1BIO
1DFP
1DIC
1DST
1DSU
1FDP
1HFD
2XW9
2XWA
2XWB
4CBN
4CBO
4D9R
PDBsum 1BIO
1DFP
1DIC
1DST
1DSU
1FDP
1HFD
2XW9
2XWA
2XWB
4CBN
4CBO
4D9R
ProteinModelPortal P00746
SMR P00746
BioGrid 108039
IntAct P00746
STRING 9606.ENSP00000332139
BindingDB P00746
ChEMBL CHEMBL2176771
MEROPS S01.191
PhosphoSite P00746
DMDM 158515408
PaxDb P00746
PRIDE P00746
Ensembl ENST00000327726
ENST00000617994
GeneID 1675
KEGG hsa:1675
UCSC uc002lqc.3
CTD 1675
GeneCards GC19P000859
HGNC HGNC:2771
HPA CAB016383
MIM 134350
613912
neXtProt NX_P00746
Orphanet 169467
PharmGKB PA142
eggNOG COG5640
GeneTree ENSGT00760000118895
HOVERGEN HBG013304
InParanoid P00746
KO K01334
OrthoDB EOG7MKW6Q
PhylomeDB P00746
TreeFam TF333630
BRENDA 3.4.21.46
Reactome REACT_8001
ChiTaRS CFD
EvolutionaryTrace P00746
GenomeRNAi 1675
NextBio 6892
PRO PR:P00746
Proteomes UP000005640
UP000005640
Bgee P00746
CleanEx HS_CFD
ExpressionAtlas P00746
Genevestigator P00746
GO GO:0005576
GO:0005615
GO:0070062
GO:0031093
GO:0004252
GO:0008236
GO:0007596
GO:0006956
GO:0006957
GO:0045087
GO:0030168
GO:0002576
GO:0006508
InterPro IPR001254
IPR018114
IPR001314
IPR009003
Pfam PF00089
PRINTS PR00722
SMART SM00020
SUPFAM SSF50494
PROSITE PS50240
PS00134
PS00135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

GO:0003817

complement factor D activity

PMID:P00746

ECO:0000314

F

Figure 5 depects that overall, the tertiary structure of the S94Y/T214S/S215W mutant is very similar to that of native factor D.

complete
CACAO 9318

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114
InterPro:IPR037561

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

involved_in

GO:0006957

complement activation, alternative pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037561

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

PMID:1374388[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006956

complement activation

PMID:1374388[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:1374388[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:1374388[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031093

platelet alpha granule lumen

Reactome:R-HSA-481007

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006957

complement activation, alternative pathway

Reactome:R-HSA-173736

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748
Reactome:R-HSA-481007
Reactome:R-HSA-183122
Reactome:R-HSA-173745

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

involved_in

GO:0002576

platelet degranulation

Reactome:R-HSA-114608

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006957

complement activation, alternative pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0179

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 White, RT et al. (1992) Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J. Biol. Chem. 267 9210-3 PubMed GONUTS page