GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

MOUSE:BCL2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Bcl2 (synonyms: Bcl-2)
Protein Name(s) Apoptosis regulator Bcl-2
External Links
UniProt P10417
EMBL L31532
M16506
M16506
AC122842
AC162916
CH466520
BC095964
CCDS CCDS15209.1
PIR A25960
B25960
RefSeq NP_033871.2
UniGene Mm.257460
ProteinModelPortal P10417
SMR P10417
DIP DIP-1065N
IntAct P10417
MINT MINT-209615
PhosphoSite P10417
PaxDb P10417
PRIDE P10417
Ensembl ENSMUST00000112751
ENSMUST00000189999
GeneID 12043
KEGG mmu:12043
UCSC uc007cgw.1
CTD 596
MGI MGI:88138
eggNOG NOG275924
GeneTree ENSGT00530000062935
HOGENOM HOG000056452
HOVERGEN HBG004472
InParanoid P10417
KO K02161
OMA IVLKYIH
OrthoDB EOG70GMGD
TreeFam TF315834
Reactome REACT_198658
REACT_223399
ChiTaRS Bcl2
NextBio 280313
PRO PR:P10417
Proteomes UP000000589
CleanEx MM_BCL2
ExpressionAtlas P10417
Genevestigator P10417
GO GO:0005737
GO:0005829
GO:0005783
GO:0005789
GO:0005622
GO:0016020
GO:0031966
GO:0005741
GO:0005739
GO:0043209
GO:0031965
GO:0005634
GO:0046930
GO:0015267
GO:0016248
GO:0046982
GO:0042803
GO:0051721
GO:0019903
GO:0043565
GO:0008134
GO:0007015
GO:0008637
GO:0006915
GO:0031103
GO:0007409
GO:0030183
GO:0001782
GO:0002326
GO:0042100
GO:0050853
GO:0001662
GO:0001658
GO:0043375
GO:0007569
GO:0016049
GO:0000902
GO:0008283
GO:0006874
GO:0042149
GO:0071456
GO:0071310
GO:0021747
GO:0051607
GO:0048589
GO:0048066
GO:0048546
GO:0043583
GO:0032469
GO:0097192
GO:0008625
GO:0048041
GO:0022612
GO:0032835
GO:0040007
GO:0031069
GO:0030097
GO:0048873
GO:0002520
GO:0008630
GO:0070059
GO:0008631
GO:0001822
GO:0001776
GO:0002260
GO:0002320
GO:0008584
GO:0006582
GO:0030318
GO:0014031
GO:0001656
GO:2000811
GO:0043066
GO:2001234
GO:0010523
GO:0030308
GO:0030336
GO:0008285
GO:0032848
GO:2001240
GO:2000134
GO:2001243
GO:0045930
GO:0033033
GO:0043524
GO:0030279
GO:0033689
GO:0046671
GO:0051402
GO:0048599
GO:0035265
GO:0009887
GO:0001503
GO:0001541
GO:0018105
GO:0018107
GO:0048753
GO:0043473
GO:0030890
GO:0043085
GO:0030307
GO:0008284
GO:0048087
GO:0045636
GO:0040018
GO:0014042
GO:0033138
GO:0048743
GO:0014911
GO:0009791
GO:0006470
GO:0000209
GO:0072593
GO:0042981
GO:0051924
GO:0050790
GO:0051726
GO:0001952
GO:0048070
GO:0010468
GO:0010559
GO:0046902
GO:0051881
GO:0006808
GO:0043067
GO:0043497
GO:0043496
GO:0032880
GO:0031647
GO:0022898
GO:0045069
GO:0001836
GO:0003014
GO:0034097
GO:0042493
GO:0010332
GO:0051384
GO:0042542
GO:0010039
GO:0002931
GO:0035094
GO:0006979
GO:0048545
GO:0009636
GO:0010224
GO:0016337
GO:0048536
GO:0030217
GO:0033077
GO:0043029
GO:0002360
GO:0048538
GO:0001657
InterPro IPR013278
IPR002475
IPR004725
IPR020717
IPR020726
IPR020728
IPR003093
IPR020731
IPR026298
PANTHER PTHR11256
PTHR11256:SF11
Pfam PF00452
PF02180
PRINTS PR01863
PR01862
SMART SM00265
TIGRFAMs TIGR00865
PROSITE PS50062
PS01080
PS01258
PS01259
PS01260
PS50063

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010506

regulation of autophagy

PMID:22258505[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000378

negative regulation of reactive oxygen species metabolic process

PMID:18281291[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

UniProtKB:Q61221

P

part_of:(GO:0071456)

Seeded From UniProt

complete

involved_in

GO:0010507

negative regulation of autophagy

PMID:18281291[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0071456)

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

PMID:9843949[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046902

regulation of mitochondrial membrane permeability

PMID:9843949[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001836

release of cytochrome c from mitochondria

PMID:9843949[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045069

regulation of viral genome replication

PMID:16950491[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043473

pigmentation

PMID:8402909[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031069

hair follicle morphogenesis

PMID:8402909[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

PMID:11983915[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000135647
UniProtKB:P10415
UniProtKB:Q07817
ZFIN:ZDB-GENE-010730-1

P

Seeded From UniProt

complete

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:108052
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
UniProtKB:Q07820

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2199
RGD:2200
RGD:620525
RGD:620621
RGD:620717
RGD:621635
RGD:70984
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q07820
UniProtKB:Q16611
UniProtKB:Q92843
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-030825-1
ZFIN:ZDB-GENE-051012-1

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:102687
MGI:MGI:88138
MGI:MGI:88139
PANTHER:PTN000135647
RGD:2199
RGD:2200
RGD:620525
UniProtKB:P10415
UniProtKB:Q07817
UniProtKB:Q07820
UniProtKB:Q92843
WB:WBGene00000423
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-010730-1

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330841
MGI:MGI:1858494
MGI:MGI:99702
PANTHER:PTN000135648
RGD:621635
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q16611

F

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029131
MGI:MGI:101769
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2200
UniProtKB:P10415
UniProtKB:Q07817
WB:WBGene00000423

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001234

negative regulation of apoptotic signaling pathway

PMID:11546872[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001234

negative regulation of apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000811

negative regulation of anoikis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:14660795[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000763)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

PMID:14660795[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098609

cell-cell adhesion

PMID:15292044[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

has_participant:(EMAPA:28281)|has_participant:(EMAPA:28407)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:12082633[12]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1309517

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072593

reactive oxygen species metabolic process

PMID:9681465[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

occurs_in:(EMAPA:16894)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072593

reactive oxygen species metabolic process

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000763)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072593

reactive oxygen species metabolic process

PMID:10726970[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071456

cellular response to hypoxia

PMID:7595537[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071310

cellular response to organic substance

PMID:12606450[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:15776018[17]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051924

regulation of calcium ion transport

PMID:8022822[18]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051726

regulation of cell cycle

PMID:10200548[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

  • occurs_in:(EMAPA:17525)
  • occurs_in:(CL:0000362)

Seeded From UniProt

complete

enables

GO:0051721

protein phosphatase 2A binding

PMID:16717086[20]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:16894)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051607

defense response to virus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:10762311[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:7546744[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

  • occurs_in:(EMAPA:18438)
  • occurs_in:(CL:0000540)

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051384

response to glucocorticoid

PMID:8372353[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051384

response to glucocorticoid

PMID:8313913[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050853

B cell receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050790

regulation of catalytic activity

PMID:9681465[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:16894)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048873

homeostasis of number of cells within a tissue

PMID:9241272[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048873

homeostasis of number of cells within a tissue

PMID:16427619[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

occurs_in:(EMAPA:36528)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048753

pigment granule organization

PMID:8758925[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

  • occurs_in:(EMAPA:18771)
  • occurs_in:(CL:0000148)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048743

positive regulation of skeletal muscle fiber development

PMID:11146504[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:35578)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048599

oocyte development

PMID:7628407[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

  • occurs_in:(EMAPA:30755)
  • results_in_development_of:(CL:0000023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048589

developmental growth

PMID:15818405[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048546

digestive tract morphogenesis

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048545

response to steroid hormone

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048538

thymus development

PMID:15818405[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

results_in_development_of:(EMAPA:18768)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048538

thymus development

PMID:9241272[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:18768)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048538

thymus development

PMID:15818405[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_development_of:(EMAPA:18768)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048536

spleen development

PMID:15818405[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

results_in_development_of:(EMAPA:18767)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048536

spleen development

PMID:15818405[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_development_of:(EMAPA:18767)

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048087

positive regulation of developmental pigmentation

PMID:9241272[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048087

positive regulation of developmental pigmentation

PMID:10674380[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(EMAPA:17525)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048070

regulation of developmental pigmentation

PMID:15818405[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048066

developmental pigmentation

PMID:11709185[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048066

developmental pigmentation

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

has_participant:(EMAPA:18769)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048066

developmental pigmentation

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048041

focal adhesion assembly

PMID:15292044[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

occurs_in:(EMAPA:28281)|occurs_in:(EMAPA:28407)

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8918887[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P70444

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:7834748[36]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q61337

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:11226327[37]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:10582606[38]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

F

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046671

negative regulation of retinal cell programmed cell death

PMID:10321489[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

  • regulates_o_occurs_in:(EMAPA:17168)
  • regulates_o_occurs_in:(CL:0000740)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045930

negative regulation of mitotic cell cycle

PMID:9241272[25]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045636

positive regulation of melanocyte differentiation

PMID:16427619[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

  • occurs_in:(EMAPA:36528)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000148)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045471

response to ethanol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043583

ear development

PMID:11709185[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043583

ear development

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_development_of:(EMAPA:16193)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043583

ear development

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:9681465[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

  • occurs_in:(EMAPA:17787)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:11027399[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

  • occurs_in:(EMAPA:17597)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:10762311[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

  • regulates_o_occurs_in:(CL:0000540)
  • occurs_in:(EMAPA:17155)|occurs_in:(EMAPA:16797)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:8625820[41]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

GO:0010506

regulation of autophagy

PMID:22258505[1]

ECO:0000315

P

Figure 2 shows that in the BCL2 mutant mice exercise and starvation induced autophagy were blocked

complete
CACAO 6204

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:7472523[42]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:32763)
  • regulates_o_occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:7546744[22]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043497

regulation of protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043375

CD8-positive, alpha-beta T cell lineage commitment

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:32760)
  • results_in_commitment_to:(CL:0000625)|occurs_in(EMAPA:18768)
  • results_in_commitment_to:(CL:0000625)|occurs_in(EMAPA:18767)
  • results_in_commitment_to:(CL:0000625)|occurs_in(EMAPA:35523)
  • results_in_commitment_to:(CL:0000625)

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

PMID:7953633[43]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)
  • part_of:(CL:0000540)|part_of:(EMAPA:16894)
  • part_of:(CL:0000127)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043085

positive regulation of catalytic activity

PMID:17382917[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:18603)
  • regulates_o_occurs_in:(CL:0000192)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043067

regulation of programmed cell death

PMID:16672320[45]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97486

P

regulates_o_occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7834747[46]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108047

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:9681465[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:18767)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:9374413[47]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • regulates_o_occurs_in:(EMAPA:16039)
  • regulates_o_occurs_in:(CL:0000101)|regulates_o_occurs_in:(EMAPA:16039)
  • regulates_o_occurs_in:(CL:0000101)|regulates_o_occurs_in:(EMAPA:16039)
  • regulates_o_occurs_in:(CL:0000101)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:9153592[48]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

  • regulates_o_occurs_in:(EMAPA:17787)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8760259[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8663032[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8623928[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

regulates_o_occurs_in:(EMAPA:17954)|regulates_o_occurs_in:(EMAPA:17954)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • regulates_o_occurs_in:(EMAPA:16332)
  • regulates_o_occurs_in:(CL:0000542)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7840250[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:17373)|regulates_o_occurs_in:(EMAPA:17645)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:17068116[53]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

regulates_o_occurs_in:(EMAPA:17023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:14660795[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:10602483[54]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • regulates_o_occurs_in:(EMAPA:18939)
  • regulates_o_occurs_in:(CL:0000066)|regulates_o_occurs_in:(EMAPA:32834)
  • regulates_o_occurs_in:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:10321489[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

  • regulates_o_occurs_in:(EMAPA:17168)
  • regulates_o_occurs_in:(CL:0000740)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:10200548[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

  • regulates_o_occurs_in:(EMAPA:17525)
  • regulates_o_occurs_in:(CL:0000362)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:9560217[55]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8313913[24]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7834747[46]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7751019[56]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:17267035[57]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000451)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:14660795[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:14551195[58]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8080725[59]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:8050499[60]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7772249[61]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:7650367[62]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:1373874[63]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:15776018[17]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043029

T cell homeostasis

PMID:17591857[64]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043029

T cell homeostasis

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043029

T cell homeostasis

PMID:7650488[65]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

PMID:8918887[35]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108093

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

PMID:15818405[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

occurs_in:(EMAPA:18767)

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:9098922[66]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:16039)|occurs_in:(EMAPA:16039)|occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:8949945[67]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042149

cellular response to glucose starvation

PMID:7595537[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042100

B cell proliferation

PMID:1373874[63]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040018

positive regulation of multicellular organism growth

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040008

regulation of growth

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040008

regulation of growth

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035265

organ growth

PMID:8623928[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035265

organ growth

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035094

response to nicotine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034097

response to cytokine

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000763)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034097

response to cytokine

PMID:9184696[68]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033689

negative regulation of osteoblast proliferation

PMID:10193316[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033138

positive regulation of peptidyl-serine phosphorylation

PMID:15613488[70]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161
MGI:MGI:99702

P

regulates_o_has_input:(MGI:MGI:96623)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033077

T cell differentiation in thymus

PMID:9028316[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033077

T cell differentiation in thymus

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:18768)
  • results_in_acquisition_of_features_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033033

negative regulation of myeloid cell apoptotic process

PMID:9202146[72]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000763)

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032880

regulation of protein localization

PMID:9950951[73]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032848

negative regulation of cellular pH reduction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032835

glomerulus development

PMID:8623928[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_development_of:(EMAPA:28239)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032469

endoplasmic reticulum calcium ion homeostasis

PMID:15613488[70]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161
MGI:MGI:88138

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:11980919[74]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16985)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

PMID:8030757[75]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)|part_of:(EMAPA:18631)

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031647

regulation of protein stability

PMID:14660795[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031103

axon regeneration

PMID:9009190[76]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(EMAPA:17168)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030890

positive regulation of B cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030336

negative regulation of cell migration

PMID:15292044[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:28281)|regulates_o_occurs_in:(EMAPA:28407)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030318

melanocyte differentiation

PMID:12086670[77]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:104554

P

results_in_acquisition_of_features_of:(CL:0000148)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030318

melanocyte differentiation

PMID:8758925[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

  • occurs_in:(EMAPA:18771)
  • results_in_acquisition_of_features_of:(CL:0000148)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030318

melanocyte differentiation

PMID:12086670[77]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

results_in_acquisition_of_features_of:(CL:0000148)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030318

melanocyte differentiation

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:35246)
  • results_in_acquisition_of_features_of:(CL:0000148)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030308

negative regulation of cell growth

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000763)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030307

positive regulation of cell growth

PMID:8022822[18]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030279

negative regulation of ossification

PMID:9008714[78]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030217

T cell differentiation

PMID:9215624[79]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96562

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030217

T cell differentiation

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_acquisition_of_features_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030183

B cell differentiation

PMID:9028316[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

occurs_in:(EMAPA:32760)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030183

B cell differentiation

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_acquisition_of_features_of:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030097

hemopoiesis

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0022898

regulation of transmembrane transporter activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0022612

gland morphogenesis

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021747

cochlear nucleus development

PMID:11027399[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:17597)

Seeded From UniProt

complete

enables

GO:0019903

protein phosphatase binding

PMID:12617961[80]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:16894)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0018107

peptidyl-threonine phosphorylation

PMID:14660795[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0018105

peptidyl-serine phosphorylation

PMID:14660795[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016248

channel inhibitor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:8030757[75]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)|part_of:(EMAPA:18631)

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:7896880[81]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014911

positive regulation of smooth muscle cell migration

PMID:17382917[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:18603)
  • regulates_o_results_in_movement_of:(CL:0000192)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014042

positive regulation of neuron maturation

PMID:9547242[82]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • regulates_o_occurs_in:(EMAPA:16797)
  • regulates_o_results_in_maturation_of:(CL:0000101)|regulates_o_occurs_in(EMAPA:16797)
  • regulates_o_results_in_maturation_of:(CL:0000101)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014031

mesenchymal cell development

PMID:8623928[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:35592)
  • results_in_development_of:(CL:0000134)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010559

regulation of glycoprotein biosynthetic process

PMID:15292044[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_occurs_in:(EMAPA:28281)|regulates_o_occurs_in:(EMAPA:28407)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010523

negative regulation of calcium ion transport into cytosol

PMID:15613488[70]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161
MGI:MGI:96623
MGI:MGI:99702

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:15292044[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

  • occurs_in:(EMAPA:28281)
  • has_regulation_target:(MGI:MGI:96604)|occurs_in(EMAPA:28281)
  • has_regulation_target:(MGI:MGI:96602)|occurs_in(EMAPA:28281)
  • has_regulation_target:(MGI:MGI:96605)|occurs_in(EMAPA:28281)
  • has_regulation_target:(MGI:MGI:96610)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010468

regulation of gene expression

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(CL:0000763)
  • has_regulation_target:(MGI:MGI:98351)|occurs_in(CL:0000763)
  • has_regulation_target:(MGI:MGI:88271)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:8372353[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:18767)
  • occurs_in:(CL:0000084)|occurs_in:(EMAPA:18767)
  • occurs_in:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:16332)
  • occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:17068116[53]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

occurs_in:(EMAPA:17023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:10815637[83]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

occurs_in:(EMAPA:32834)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010224

response to UV-B

PMID:10200548[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010039

response to iron ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009887

animal organ morphogenesis

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

has_participant:(EMAPA:17373)|has_participant:(EMAPA:16542)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:9241272[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:11709185[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:8755480[84]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:10674380[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009636

response to toxic substance

PMID:10602483[54]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009636

response to toxic substance

PMID:16717086[20]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009636

response to toxic substance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008637

apoptotic mitochondrial changes

PMID:14707049[85]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008631

intrinsic apoptotic signaling pathway in response to oxidative stress

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:15983387[86]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2442925

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:10597216[87]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008584

male gonad development

PMID:9241272[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

results_in_development_of:(EMAPA:31476)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:8663032[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

PMID:8084613[88]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:10762311[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

acts_on_population_of:(CL:0000540)

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:17382917[44]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P01108

F

  • occurs_in:(EMAPA:18603)
  • occurs_in:(CL:0000192)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007569

cell aging

PMID:8372353[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:18767)
  • occurs_in:(CL:0000084)|occurs_in:(EMAPA:18767)
  • occurs_in:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007409

axonogenesis

PMID:9009190[76]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007015

actin filament organization

PMID:9950951[73]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:12855558[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:8372353[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:32760)
  • occurs_in:(CL:0000084)|occurs_in:(EMAPA:32760)
  • occurs_in:(CL:0000236)|occurs_in:(EMAPA:18768)
  • occurs_in:(CL:0000084)|occurs_in:(EMAPA:18768)
  • occurs_in:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:16332)
  • occurs_in:(CL:0000542)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:8949945[67]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:8022822[18]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006874

cellular calcium ion homeostasis

PMID:7945396[89]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006808

regulation of nitrogen utilization

PMID:9241272[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006582

melanin metabolic process

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

occurs_in:(EMAPA:18771)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006470

protein dephosphorylation

PMID:16717086[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:8030757[75]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)|part_of:(EMAPA:18631)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:14551195[58]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:12050152[90]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

PMID:15613488[70]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:8030757[75]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)|part_of:(EMAPA:18631)

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[91]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14651853[92]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:7953633[43]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)
  • part_of:(CL:0000540)|part_of:(EMAPA:16894)
  • part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:7945396[89]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:12420306[93]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:7896880[81]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:8030757[75]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)|part_of:(EMAPA:18631)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7675327[94]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32845)
  • part_of:(CL:0000598)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7563251[95]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17787)
  • part_of:(CL:0000121)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7546744[22]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2199

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:8030757[75]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:16894)|part_of:(EMAPA:18631)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7953633[43]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16894)
  • part_of:(CL:0000540)|part_of:(EMAPA:16894)
  • part_of:(CL:0000127)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7945396[89]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7896880[81]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7546744[22]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003014

renal system process

PMID:8760259[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

occurs_in:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002931

response to ischemia

PMID:10488913[96]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002520

immune system development

PMID:8372353[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002520

immune system development

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158305

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002360

T cell lineage commitment

PMID:8788039[97]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:18767)
  • occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002326

B cell lineage commitment

PMID:8788039[97]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

  • occurs_in:(EMAPA:32760)
  • results_in_commitment_to:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002320

lymphoid progenitor cell differentiation

PMID:9028316[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_acquisition_of_features_of:(CL:0000037)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002260

lymphocyte homeostasis

PMID:15818405[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002260

lymphocyte homeostasis

PMID:11709185[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002260

lymphocyte homeostasis

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002260

lymphocyte homeostasis

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

enables

GO:0002020

protease binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001952

regulation of cell-matrix adhesion

PMID:15292044[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

regulates_o_has_participant:(EMAPA:28281)|regulates_o_has_participant:(EMAPA:28407)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:9241272[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:16672320[45]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97486

P

results_in_development_of:(EMAPA:17373)|results_in_development_of:(EMAPA:35592)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:11709185[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:9950951[73]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:8760259[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:7840250[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:17373)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:7812968[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:16282979[98]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:15818405[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:11709185[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_development_of:(EMAPA:17373)|results_in_development_of:(EMAPA:35592)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001782

B cell homeostasis

PMID:8170972[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001782

B cell homeostasis

PMID:7650488[65]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001776

leukocyte homeostasis

PMID:9028316[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

occurs_in:(EMAPA:18768)|occurs_in:(EMAPA:35523)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001662

behavioral fear response

PMID:16095731[99]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:16672320[45]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97486

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001658

branching involved in ureteric bud morphogenesis

PMID:14699151[100]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001657

ureteric bud development

PMID:8623928[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001656

metanephros development

PMID:8623928[51]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2156165

P

results_in_development_of:(EMAPA:17954)|results_in_development_of:(EMAPA:17954)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001656

metanephros development

PMID:7840250[52]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:17373)|results_in_development_of:(EMAPA:17645)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

PMID:7628407[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857134

P

results_in_development_of:(EMAPA:30755)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001503

ossification

PMID:10193316[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000902

cell morphogenesis

PMID:10193316[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857430

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000209

protein polyubiquitination

PMID:16717086[20]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P10415

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015267

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015267

P

Seeded From UniProt

complete

involved_in

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:2001234

negative regulation of apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:2000811

negative regulation of anoikis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0051924

regulation of calcium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0043497

regulation of protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0042100

B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0035094

response to nicotine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

involved_in

GO:0032848

negative regulation of cellular pH reduction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

involved_in

GO:0030890

positive regulation of B cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0022898

regulation of transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

enables

GO:0016248

channel inhibitor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

involved_in

GO:0010039

response to iron ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

enables

GO:0002020

protease binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

F

Seeded From UniProt

complete

involved_in

GO:0000209

protein polyubiquitination

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P10415
ensembl:ENSP00000381185

P

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R2B3
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R2B3
ensembl:ENSP00000381185

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004725

C

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003093
InterPro:IPR004725
InterPro:IPR020717
InterPro:IPR020726
InterPro:IPR020728
InterPro:IPR020731
InterPro:IPR026298
InterPro:IPR036834

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013278

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0182

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 He, C et al. (2012) Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 481 511-5 PubMed GONUTS page
  2. ↑ 2.0 2.1 Zhang, H et al. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283 10892-903 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Narita, M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 14681-6 PubMed GONUTS page
  4. ↑ Sciortino, MT et al. () Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology 356 136-46 PubMed GONUTS page
  5. ↑ 5.0 5.1 Veis, DJ et al. (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75 229-40 PubMed GONUTS page
  6. ↑ Limana, F et al. (2002) bcl-2 overexpression promotes myocyte proliferation. Proc. Natl. Acad. Sci. U.S.A. 99 6257-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ Puthalakath, H et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293 1829-32 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Deng, X et al. (2004) Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions. Proc. Natl. Acad. Sci. U.S.A. 101 153-8 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 Deng, X et al. (2003) Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood 102 3179-85 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Ziehr, J et al. (2004) Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice. Am. J. Physiol. Renal Physiol. 287 F1154-63 PubMed GONUTS page
  12. ↑ Fleischer, A et al. (2002) Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene 21 3181-9 PubMed GONUTS page
  13. ↑ 13.0 13.1 13.2 13.3 Hochman, A et al. (1998) Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice. J. Neurochem. 71 741-8 PubMed GONUTS page
  14. ↑ Hochman, A et al. (2000) Developmental changes in antioxidant enzymes and oxidative damage in kidneys, liver and brain of bcl-2 knockout mice. Cell. Mol. Biol. (Noisy-le-grand) 46 41-52 PubMed GONUTS page
  15. ↑ 15.0 15.1 Myers, KM et al. (1995) Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability. J. Neurochem. 65 2432-40 PubMed GONUTS page
  16. ↑ Mu, J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol. Reprod. 68 1968-74 PubMed GONUTS page
  17. ↑ 17.0 17.1 Ruiz-Vela, A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep. 6 379-85 PubMed GONUTS page
  18. ↑ 18.0 18.1 18.2 Lam, M et al. (1994) Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc. Natl. Acad. Sci. U.S.A. 91 6569-73 PubMed GONUTS page
  19. ↑ 19.0 19.1 19.2 Gillardon, F et al. (1999) Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. Cell Death Differ. 6 55-60 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 20.3 Lin, SS et al. (2006) PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J. Biol. Chem. 281 23003-12 PubMed GONUTS page
  21. ↑ 21.0 21.1 21.2 Middleton, G et al. (2000) Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations. Eur. J. Neurosci. 12 819-27 PubMed GONUTS page
  22. ↑ 22.0 22.1 22.2 22.3 Greenlund, LJ et al. (1995) Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 15 649-61 PubMed GONUTS page
  23. ↑ 23.0 23.1 23.2 23.3 23.4 Nakayama, K et al. (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261 1584-8 PubMed GONUTS page
  24. ↑ 24.0 24.1 Merino, R et al. (1994) Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J. 13 683-91 PubMed GONUTS page
  25. ↑ 25.0 25.1 25.2 25.3 25.4 25.5 25.6 25.7 Knudson, CM & Korsmeyer, SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat. Genet. 16 358-63 PubMed GONUTS page
  26. ↑ 26.0 26.1 Mak, SS et al. (2006) Indispensable role of Bcl2 in the development of the melanocyte stem cell. Dev. Biol. 291 144-53 PubMed GONUTS page
  27. ↑ 27.0 27.1 Yamamura, K et al. (1996) Accelerated disappearance of melanocytes in bcl-2-deficient mice. Cancer Res. 56 3546-50 PubMed GONUTS page
  28. ↑ Dominov, JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev. Dyn. 220 18-26 PubMed GONUTS page
  29. ↑ 29.0 29.1 Ratts, VS et al. (1995) Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology 136 3665-8 PubMed GONUTS page
  30. ↑ 30.0 30.1 30.2 30.3 30.4 30.5 30.6 30.7 30.8 Bouillet, P et al. (2005) Polycystic kidney disease prevented by transgenic RNA interference. Cell Death Differ. 12 831-3 PubMed GONUTS page
  31. ↑ 31.0 31.1 31.2 31.3 31.4 31.5 31.6 31.7 Kamada, S et al. (1995) bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res. 55 354-9 PubMed GONUTS page
  32. ↑ 32.00 32.01 32.02 32.03 32.04 32.05 32.06 32.07 32.08 32.09 32.10 32.11 32.12 32.13 32.14 32.15 Nakayama, K et al. (1994) Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. U.S.A. 91 3700-4 PubMed GONUTS page
  33. ↑ 33.0 33.1 Müller-Röver, S et al. (1999) Hair follicle apoptosis and Bcl-2. J. Investig. Dermatol. Symp. Proc. 4 272-7 PubMed GONUTS page
  34. ↑ 34.00 34.01 34.02 34.03 34.04 34.05 34.06 34.07 34.08 34.09 34.10 34.11 34.12 Bouillet, P et al. (2001) Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev. Cell 1 645-53 PubMed GONUTS page
  35. ↑ 35.0 35.1 Wang, K et al. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10 2859-69 PubMed GONUTS page
  36. ↑ Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page
  37. ↑ Vila, M et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 98 2837-42 PubMed GONUTS page
  38. ↑ Vukosavic, S et al. (1999) Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 73 2460-8 PubMed GONUTS page
  39. ↑ 39.0 39.1 Cellerino, A et al. (1999) Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice. Neuroreport 10 1091-5 PubMed GONUTS page
  40. ↑ 40.0 40.1 Mostafapour, SP et al. (2000) Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal. J. Comp. Neurol. 426 561-71 PubMed GONUTS page
  41. ↑ Middleton, G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122 695-701 PubMed GONUTS page
  42. ↑ Sagot, Y et al. (1995) Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J. Neurosci. 15 7727-33 PubMed GONUTS page
  43. ↑ 43.0 43.1 43.2 Mizuguchi, M et al. (1994) Expression of Bcl-2 protein in murine neural cells in culture. Brain Res. 649 197-202 PubMed GONUTS page
  44. ↑ 44.0 44.1 44.2 Hou, Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc. Res. 75 186-94 PubMed GONUTS page
  45. ↑ 45.0 45.1 45.2 Dziarmaga, A et al. (2006) Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. J. Am. Soc. Nephrol. 17 1568-75 PubMed GONUTS page
  46. ↑ 46.0 46.1 Takayama, S et al. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80 279-84 PubMed GONUTS page
  47. ↑ Piñón, LG et al. (1997) Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. Development 124 4173-8 PubMed GONUTS page
  48. ↑ Tanabe, H et al. (1997) Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death. Eur. J. Neurosci. 9 848-56 PubMed GONUTS page
  49. ↑ 49.0 49.1 49.2 Sorenson, CM et al. (1996) Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse. Am. J. Physiol. 271 F184-93 PubMed GONUTS page
  50. ↑ 50.0 50.1 Borner, C (1996) Diminished cell proliferation associated with the death-protective activity of Bcl-2. J. Biol. Chem. 271 12695-8 PubMed GONUTS page
  51. ↑ 51.0 51.1 51.2 51.3 51.4 51.5 Nagata, M et al. (1996) Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice. Am. J. Pathol. 148 1601-11 PubMed GONUTS page
  52. ↑ 52.0 52.1 52.2 Sorenson, CM et al. (1995) Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am. J. Physiol. 268 F73-81 PubMed GONUTS page
  53. ↑ 53.0 53.1 Przemeck, SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G620-7 PubMed GONUTS page
  54. ↑ 54.0 54.1 Pritchard, DM et al. (1999) Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18 7287-93 PubMed GONUTS page
  55. ↑ Jürgensmeier, JM et al. (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 4997-5002 PubMed GONUTS page
  56. ↑ Broome, HE et al. (1995) Apoptosis and Bcl-2 expression in cultured murine splenic T cells. Immunology 84 375-82 PubMed GONUTS page
  57. ↑ Chen, M et al. (2007) Regulation of the lifespan in dendritic cell subsets. Mol. Immunol. 44 2558-65 PubMed GONUTS page
  58. ↑ 58.0 58.1 Kocher, O et al. (2003) Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism. J. Biol. Chem. 278 52820-5 PubMed GONUTS page
  59. ↑ Kondo, S et al. (1994) bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy. Br. J. Cancer 70 421-6 PubMed GONUTS page
  60. ↑ Kondo, S et al. (1994) bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp. Cell Res. 213 428-32 PubMed GONUTS page
  61. ↑ Takayama, S et al. (1994) Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein. DNA Cell Biol. 13 679-92 PubMed GONUTS page
  62. ↑ Broome, HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155 2311-7 PubMed GONUTS page
  63. ↑ 63.0 63.1 Borzillo, GV et al. (1992) Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture. Oncogene 7 869-76 PubMed GONUTS page
  64. ↑ Wojciechowski, S et al. (2007) Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J. Exp. Med. 204 1665-75 PubMed GONUTS page
  65. ↑ 65.0 65.1 Chao, DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182 821-8 PubMed GONUTS page
  66. ↑ Wlodarczyk, BC et al. (1996) Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology 54 284-97 PubMed GONUTS page
  67. ↑ 67.0 67.1 Lezoualc'h, F et al. (1996) Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol. Brain Res. 738 176-9 PubMed GONUTS page
  68. ↑ Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
  69. ↑ 69.0 69.1 69.2 Boot-Handford, RP et al. (1998) The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int J Exp Pathol 79 329-35 PubMed GONUTS page
  70. ↑ 70.0 70.1 70.2 70.3 Oakes, SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 102 105-10 PubMed GONUTS page
  71. ↑ 71.0 71.1 71.2 71.3 Matsuzaki, Y et al. (1997) Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood 89 853-62 PubMed GONUTS page
  72. ↑ Barge, RM et al. (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett. 409 207-10 PubMed GONUTS page
  73. ↑ 73.0 73.1 73.2 Sorenson, CM (1999) Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice. Am. J. Physiol. 276 F210-7 PubMed GONUTS page
  74. ↑ Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page
  75. ↑ 75.0 75.1 75.2 75.3 75.4 75.5 Novack, DV & Korsmeyer, SJ (1994) Bcl-2 protein expression during murine development. Am. J. Pathol. 145 61-73 PubMed GONUTS page
  76. ↑ 76.0 76.1 Chen, DF et al. (1997) Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 385 434-9 PubMed GONUTS page
  77. ↑ 77.0 77.1 McGill, GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109 707-18 PubMed GONUTS page
  78. ↑ Amling, M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J. Cell Biol. 136 205-13 PubMed GONUTS page
  79. ↑ Maraskovsky, E et al. (1997) Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell 89 1011-9 PubMed GONUTS page
  80. ↑ Erin, N et al. (2003) Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue. Neuroscience 117 541-55 PubMed GONUTS page
  81. ↑ 81.0 81.1 81.2 Yang, T et al. (1995) The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128 1173-84 PubMed GONUTS page
  82. ↑ Middleton, G et al. (1998) Bcl-2 accelerates the maturation of early sensory neurons. J. Neurosci. 18 3344-50 PubMed GONUTS page
  83. ↑ Hendry, JH et al. (2000) Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation. Int. J. Radiat. Biol. 76 559-65 PubMed GONUTS page
  84. ↑ Michaelidis, TM et al. (1996) Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 17 75-89 PubMed GONUTS page
  85. ↑ Jung, KC et al. (2004) TCR-independent and caspase-independent apoptosis of murine thymocytes by CD24 cross-linking. J. Immunol. 172 795-802 PubMed GONUTS page
  86. ↑ Ishii, H et al. (2005) Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc. Natl. Acad. Sci. U.S.A. 102 9655-60 PubMed GONUTS page
  87. ↑ Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page
  88. ↑ Cotter, FE et al. (1994) Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene 9 3049-55 PubMed GONUTS page
  89. ↑ 89.0 89.1 89.2 Magnelli, L et al. (1994) Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Biochem. Biophys. Res. Commun. 204 84-90 PubMed GONUTS page
  90. ↑ Hu, J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J. Biol. Chem. 277 30253-63 PubMed GONUTS page
  91. ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
  92. ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
  93. ↑ Nakamura, N et al. (2003) Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s). Mol. Reprod. Dev. 64 113-9 PubMed GONUTS page
  94. ↑ Gillardon, F et al. (1995) Up-regulation of bax and down-regulation of bcl-2 is associated with kainate-induced apoptosis in mouse brain. Neurosci. Lett. 192 85-8 PubMed GONUTS page
  95. ↑ Gillardon, F et al. (1995) Differential regulation of bcl-2, bax, c-fos, junB, and krox-24 expression in the cerebellum of Purkinje cell degeneration mutant mice. J. Neurosci. Res. 41 708-15 PubMed GONUTS page
  96. ↑ Hata, R et al. (1999) Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metab Brain Dis 14 117-24 PubMed GONUTS page
  97. ↑ 97.0 97.1 Li, T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 7 107-14 PubMed GONUTS page
  98. ↑ Hughes, P et al. (2006) Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ. 13 1123-7 PubMed GONUTS page
  99. ↑ Einat, H et al. (2005) Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behav. Brain Res. 165 172-80 PubMed GONUTS page
  100. ↑ Sorenson, CM (2004) Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching. J. Biol. Chem. 279 11368-74 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=MOUSE:BCL2&oldid=5954264"