PMID:9028316

Citation	Matsuzaki, Y, Nakayama, K, Nakayama, K, Tomita, T, Isoda, M, Loh, DY and Nakauchi, H (1997) Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell. Blood 89:853-62
Abstract	To investigate the role of bcl-2 in lymphohematopoiesis, a long-term bone marrow reconstitution system was established. Transplantation of 1,000 c-Kit+ Sca-1+ and lineage markers negative cells from bcl-2-l-mouse bone marrow resulted in long-term reconstitution of nonlymphoid cells. However, T cells were totally absent and B-lymphocyte development was severely impaired at a very early stage of differentiation in the chimeric mouse. On the other hand, transplantation of day 14 fetal liver cells from bcl-2-l-mice resulted in generation of both T and B cells in the recipient, albeit transiently. These data suggest that bcl-2 plays a critical role in the development of lymphoid progenitor cells from the hematopoietic stem cell (HSC), but is not essential for the development of nonlymphoid cells and the self-renewal of HSC. In addition, lymphopoiesis from fetal liver HSC appears to be less dependent on bcl-2 than adult bone marrow HSC.
Links	PubMed
Keywords	Animals; Cell Differentiation/drug effects; Cell Differentiation/genetics; Graft Rejection/genetics; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/immunology; Immunologic Memory/drug effects; Lymphocytes/cytology; Lymphocytes/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins c-bcl-2/genetics; Proto-Oncogene Proteins c-bcl-2/physiology; T-Lymphocytes/drug effects
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