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PMID:8372353
| Citation |
Nakayama, K, Nakayama, K, Negishi, I, Kuida, K, Shinkai, Y, Louie, MC, Fields, LE, Lucas, PJ, Stewart, V and Alt, FW (1993) Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261:1584-8 |
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| Abstract |
The bcl-2 proto-oncogene can prevent the death of many cell types. Mice were generated that were chimeric for the homozygous inactivation of bcl-2. Lymphocytes without Bcl-2 differentiated into phenotypically mature cells. However, in vitro, the mature T cells that lacked Bcl-2 had shorter life-spans and increased sensitivity to glucocorticoids and gamma-irradiation. In contrast, stimulation of CD3 inhibited the death of these cells. T and B cells with no Bcl-2 disappeared from the bone marrow, thymus, and periphery by 4 weeks of age. Thus, Bcl-2 was dispensable for lymphocyte maturation, but was required for a stable immune system after birth. |
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| Keywords |
Animals; Antigens, CD3/immunology; Apoptosis; B-Lymphocytes/cytology; B-Lymphocytes/immunology; Base Sequence; Bone Marrow/immunology; Bone Marrow Cells; Cell Line; Chimera; Homozygote; Humans; Lymphoid Tissue/cytology; Lymphoid Tissue/immunology; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Receptors, Antigen, T-Cell/immunology; T-Lymphocytes/cytology; T-Lymphocytes/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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