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PMID:9215624
| Citation |
Maraskovsky, E, O'Reilly, LA, Teepe, M, Corcoran, LM, Peschon, JJ and Strasser, A (1997) Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell 89:1011-9 |
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| Abstract |
Signals from cytokine and antigen receptors play crucial roles during lymphocyte development. Mice lacking interleukin-7 receptor are lymphopenic, due to a defect in cell expansion at an early stage of differentiation, and the few mature T cells that develop in IL-7R-/- animals are functionally impaired. Both defects were rescued completely by overexpression of the anti-apoptosis protein Bcl-2. T cell progenitors lacking antigen receptor molecules are also blocked in differentiation and die, presumably because they fail to receive a positive signal via their pre-T cell receptor. Surprisingly, Bcl-2 did not promote survival or differentiation of T cells in rag-1-/- mice. These results provide evidence that blocking apoptosis is the essential function of IL-7R during differentiation and activation of T lymphocytes and that pre-TCR signaling blocks a pathway to apoptosis that is insensitive to Bcl-2. |
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| Keywords |
Animals; Antigens/pharmacology; Antigens, CD/genetics; Antigens, CD/metabolism; Apoptosis/immunology; CD4-Positive T-Lymphocytes/chemistry; CD4-Positive T-Lymphocytes/cytology; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/chemistry; CD8-Positive T-Lymphocytes/cytology; CD8-Positive T-Lymphocytes/immunology; Cell Differentiation/drug effects; Cell Differentiation/genetics; Cell Differentiation/immunology; Cells, Cultured; DNA-Binding Proteins/genetics; Gene Expression/immunology; Genes, RAG-1/genetics; Homeodomain Proteins; Humans; Interleukin-7/deficiency; Interleukin-7/genetics; Lymph Nodes/cytology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogens/pharmacology; Mutagenesis/immunology; Proto-Oncogene Proteins c-bcl-2/genetics; Receptors, Interleukin/genetics; Receptors, Interleukin/metabolism; Receptors, Interleukin-7; Signal Transduction/immunology; Spleen/cytology; Stem Cells/chemistry; Stem Cells/immunology; Thymus Gland/cytology; Transgenes/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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