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PMID:9202146
| Citation |
Barge, RM, Willemze, R, Vandenabeele, P, Fiers, W and Beyaert, R (1997) Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal. FEBS Lett. 409:207-10 |
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| Abstract |
To assess the potential involvement of the caspase family in the IL-3-dependent murine myeloid leukemic cell line 32D, we studied the effect of bcl-2, crmA and three synthetic caspase inhibitors on apoptosis induced by chemotherapy or IL-3 withdrawal. Apoptosis induced by IL-3 deprivation or by ActD appears to be mediated by a crmA-insensitive pathway. Cell death by IL-3 withdrawal is inhibited by the caspase-inhibitor ZVAD-fmk, but not DEVD-fmk or YVAD-cmk. In contrast, DEVD-fmk as well as ZVAD-fmk protect 32D cells from ActD-induced apoptosis. These results indicate that different caspases are involved in apoptosis induced by growth factor withdrawal and by chemotherapy. |
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| Keywords |
Animals; Apoptosis/drug effects; Cysteine Endopeptidases/metabolism; Cysteine Endopeptidases/physiology; Cysteine Proteinase Inhibitors/physiology; Dactinomycin/pharmacology; Enzyme Activation/drug effects; Interleukin-3/pharmacology; Leukemia, Myeloid/drug therapy; Leukemia, Myeloid/enzymology; Leukemia, Myeloid/pathology; Mice; Proto-Oncogene Proteins c-bcl-2/biosynthesis; Proto-Oncogene Proteins c-bcl-2/physiology; Serpins/biosynthesis; Serpins/physiology; Tumor Cells, Cultured; Viral Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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