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PMID:16950491
| Citation |
Sciortino, MT, Perri, D, Medici, MA, Grelli, S, Serafino, A, Borner, C and Mastino, A Role of Bcl-2 expression for productive herpes simplex virus 2 replication. Virology 356:136-46 |
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| Abstract |
Herpes simplex viruses infect a variety of cells in vitro. However, not all infected cells sustain a fully productive replication of these viruses. We have shown that, in U937 monocytoid cells, herpes simplex virus 2 (HSV-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. This effect was associated with a down-regulation of the Bcl-2 protein. We therefore asked whether destabilization of Bcl-2 expression could act as a limiting factor for the productive HSV-2 infection. We found that overexpression of Bcl-2 in U937 cells dramatically increased the capability of these cells to sustain a fully productive infection, while protecting against apoptosis induced by HSV-2. Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication. |
| Links |
PubMed Online version:10.1016/j.virol.2006.08.001 |
| Keywords |
Animals; Apoptosis; Cercopithecus aethiops; Herpesvirus 2, Human/pathogenicity; Humans; Mice; Proto-Oncogene Proteins c-bcl-2/metabolism; Proto-Oncogene Proteins c-bcl-2/pharmacology; U937 Cells; Vero Cells; Virus Replication/drug effects |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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