PMID:18281291

Citation	Zhang, H, Bosch-Marce, M, Shimoda, LA, Tan, YS, Baek, JH, Wesley, JB, Gonzalez, FJ and Semenza, GL (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 283:10892-903
Abstract	Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.
Links	PubMed PMC2447655 Online version:10.1074/jbc.M800102200
Keywords	Animals; Anoxia; Apoptosis Regulatory Proteins; Autophagy; Cell Death; Cytoplasm/metabolism; Hypoxia-Inducible Factor 1/metabolism; Membrane Proteins/biosynthesis; Mice; Mice, Knockout; Microtubule-Associated Proteins/biosynthesis; Mitochondria/metabolism; Mitochondrial Proteins/biosynthesis; Models, Biological; Molecular Conformation; Proteins/metabolism; Reactive Oxygen Species
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:HIF1A	involved_in	GO:1903599: positive regulation of autophagy of mitochondrion	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) has_regulation_target:(UniProtKB:Q99J83) has_regulation_target:(UniProtKB:O88597)	Seeded From UniProt	complete
MOUSE:HIF1A	involved_in	GO:1903715: regulation of aerobic respiration	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) has_regulation_target:(UniProtKB:Q99J83) has_regulation_target:(UniProtKB:O88597)	Seeded From UniProt	complete
MOUSE:HIF1A	involved_in	GO:2000378: negative regulation of reactive oxygen species metabolic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
MOUSE:HIF1A	involved_in	GO:0043066: negative regulation of apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
MOUSE:HIF1A	involved_in	GO:0010508: positive regulation of autophagy	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)|part_of:(GO:0071456) has_regulation_target:(UniProtKB:Q99J83)|part_of(GO:0071456) has_regulation_target:(UniProtKB:O88597)|part_of(GO:0071456) has_regulation_target:(UniProtKB:O55003)	Seeded From UniProt	complete
MOUSE:HIF1A	involved_in	GO:0010468: regulation of gene expression	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O55003) part_of:(GO:0071456)|has_regulation_target(UniProtKB:O55003) occurs_in:(UBERON:0002048)	Seeded From UniProt	complete
MOUSE:BCL2	involved_in	GO:2000378: negative regulation of reactive oxygen species metabolic process	ECO:0000315: mutant phenotype evidence used in manual assertion	UniProtKB:Q61221	P	part_of:(GO:0071456)	Seeded From UniProt	complete
MOUSE:BCL2	involved_in	GO:0010507: negative regulation of autophagy	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
MOUSE:BECN1	involved_in	GO:0000422: autophagy of mitochondrion	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:BECN1	involved_in	GO:0043066: negative regulation of apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456)	Seeded From UniProt	complete
MOUSE:BECN1	involved_in	GO:2000378: negative regulation of reactive oxygen species metabolic process	ECO:0000315: mutant phenotype evidence used in manual assertion	UniProtKB:Q61221	P	part_of:(GO:0071456)	Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.