GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:9374413
Citation |
Piñón, LG, Middleton, G and Davies, AM (1997) Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development. Development 124:4173-8 |
---|---|
Abstract |
To ascertain the role of endogenous Bcl-2 in maintaining the survival of developing neurons and modulating their responses to neurotrophins, we compared the in vitro and in vivo survival of cranial sensory neurons of wild-type and bcl-2 null mouse embryos. At the peak of naturally occurring neuronal death in the trigeminal ganglion at E14, trigeminal neurons from bcl-2(-/-) embryos initially survived in culture in response to NGF but were not sustained as well as neurons from wild-type embryos. At the end of the period of naturally occurring neuronal death at E18, Bcl-2-deficient trigeminal neurons survived with NGF as well as wild-type neurons. At E14 in vivo, the number of trigeminal neurons undergoing apoptosis was significantly greater in bcl-2(-/-) embryos, and there were significantly fewer neurons in the trigeminal ganglia of bcl-2(-/-) embryos at E16 and E18. Similar age-related changes in the responses of nodose ganglion neurons to BDNF were observed in cultures established from bcl-2(-/-) and wild-type embryos between E14 and E18. These results suggest that endogenous Bcl-2 is required for the sustained survival response of a subset of cranial sensory neurons to neurotrophins at particular stages of embryonic development and show that its absence leads to reduced numbers of these neurons in vivo. |
Links | |
Keywords |
Animals; Cell Death/genetics; Cell Survival/genetics; Embryonic and Fetal Development/genetics; Gene Expression Regulation, Developmental; Mice; Nervous System/cytology; Nervous System/embryology; Neurons, Afferent/cytology; Proto-Oncogene Proteins c-bcl-2/genetics |
edit table |
Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
---|---|---|---|---|---|---|---|---|
edit table |
See also
References
See Help:References for how to manage references in GONUTS.