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PMID:7945396
Citation |
Magnelli, L, Cinelli, M, Turchetti, A and Chiarugi, VP (1994) Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts. Biochem. Biophys. Res. Commun. 204:84-90 |
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Abstract |
Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events "priming" apoptosis. |
Links |
PubMed Online version:10.1006/bbrc.1994.2429 |
Keywords |
3T3 Cells; Animals; Apoptosis/physiology; Calcium/metabolism; Culture Media, Serum-Free; Fibroblasts/cytology; Fibroblasts/metabolism; Fibroblasts/physiology; GTP-Binding Proteins/biosynthesis; Gene Expression; Humans; Kinetics; Mice; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins c-bcl-2; Time Factors; Transfection |
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Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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