GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8402909
| Citation |
Veis, DJ, Sorenson, CM, Shutter, JR and Korsmeyer, SJ (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-40 |
|---|---|
| Abstract |
bcl-2-/-mice complete embryonic development, but display growth retardation and early mortality postnatally. Hematopoiesis including lymphocyte differentiation is initially normal, but thymus and spleen undergo massive apoptotic involution. Thymocytes require an apoptotic signal to manifest accelerated cell death. Renal failure results from severe polycystic kidney disease characterized by dilated proximal and distal tubular segments and hyperproliferation of epithelium and interstitium. bcl-2-/-mice turn gray with the second hair follicle cycle, implicating a defect in redox-regulated melanin synthesis. The abnormalities in these loss of function mice argue that Bcl-2 is a death repressor molecule functioning in an antioxidant pathway. |
| Links | |
| Keywords |
Animals; Apoptosis/genetics; Dexamethasone/pharmacology; Disease Models, Animal; Hair/pathology; Hematopoiesis; Hypopigmentation/genetics; Lymphocytes/physiology; Lymphoid Tissue/embryology; Lymphoid Tissue/pathology; Mice; Mice, Mutant Strains; Phenotype; Polycystic Kidney Diseases/genetics; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2; Spleen/pathology; Thymus Gland/drug effects; Thymus Gland/pathology; Thymus Gland/radiation effects |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
