GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8623928
| Citation |
Nagata, M, Nakauchi, H, Nakayama, K, Nakayama, K, Loh, D and Watanabe, T (1996) Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice. Am. J. Pathol. 148:1601-11 |
|---|---|
| Abstract |
Renal development in bcl-2-deficient mice was monitored to examine the temporal and spatial function of this gene during nephrogenesis in vivo. Extensive apoptosis occurred during abnormal nephrogenesis in bcl-2-deficient mice. In embryos and newborn mice, the sequence of morphological events was monitored by morphology in conjunction with morphometry, and bcl-2 -/-, bcl-2 +/-, and bcl-2 +/+ mice were compared. In bcl-2 -/- mice, initial induction of nephrons was detected by embryonic day 13 (E-13) as normal. Then, apoptotic cells became five times more frequent at E-13 to E-16 with a significant reduction (1/5) in nephron number at E-17 to E-19 in bcl-2 -/- mice compared with bcl-2 +/+ mice. No morphological difference was evident between bcl-2 +/- mice and bcl-2 +/+ mice by morphometry. Apoptotic cells were found mainly among the mesenchyme and less frequently in tubuli. Little apoptosis among ureteric buds was noted. In bcl-2 -/- mice at E-17 to E-19, inactive branching and insufficient convolution of ureteric buds were accompanied by fulminant apoptosis in the mesenchyme. Neonatal bcl-2 -/- mice lacked the nephrogenic zone, exhibiting renal hypoplasia. Thus, bcl-2 seems to inhibit apoptosis in renal stem cells during the induction of nephrons in vivo. |
| Links | |
| Keywords |
Animals; Apoptosis; Base Sequence; DNA/analysis; DNA/chemistry; DNA/genetics; Female; Heterozygote; Kidney/chemistry; Kidney/embryology; Kidney/pathology; Kidney Diseases/etiology; Kidney Diseases/pathology; Kidney Diseases/physiopathology; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Nephrons/embryology; Nephrons/growth & development; Nephrons/pathology; Proto-Oncogene Proteins/deficiency; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-bcl-2; Stem Cells/chemistry; Stem Cells/pathology; Stem Cells/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
