Category:GO:0016987 ! sigma factor activity

name: sigma factor activity
namespace: molecular_function
alt_id: GO:0000996
alt_id: GO:0001053
def: "Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins." [GOC:txnOH-2018]
synonym: "bacterial sigma factor activity" NARROW []
synonym: "core DNA-dependent RNA polymerase binding promoter specificity activity" EXACT []
synonym: "DNA-dependent RNA polymerase promoter selection factor" EXACT []
synonym: "plastid sigma factor activity" NARROW []
synonym: "promoter selection factor activity" NARROW []
synonym: "sigma transcription factor" EXACT []
is_a: GO:0003700 ! DNA-binding transcription factor activity
relationship: has_part: GO:0001046 ! core promoter sequence-specific DNA binding
relationship: has_part: GO:0043175 ! RNA polymerase core enzyme binding
relationship: part_of: GO:2000142 ! regulation of DNA-templated transcription initiation
intersection_of: GO:0140110 ! transcription regulator activity
intersection_of: has_part GO:0001046 ! core promoter sequence-specific DNA binding
intersection_of: has_part GO:0043175 ! RNA polymerase core enzyme binding
intersection_of: part_of GO:2000142 ! regulation of DNA-templated transcription initiation

AmiGO <GOterm>GO:0016987</GOterm>
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