BACSU:RPSB

Species (Taxon ID)	Bacillus subtilis (strain 168). (224308)
Gene Name(s)	sigB (synonyms: rpoF)
Protein Name(s)	RNA polymerase sigma-B factor General stress protein 84 GSP84 Sigma-37
External Links
UniProt	P06574
EMBL	M13927 M14508 M34995 AB001488 AL009126
PIR	A27762
RefSeq	NP_388354.2
ProteinModelPortal	P06574
SMR	P06574
IntAct	P06574
STRING	224308.BSU04730
PaxDb	P06574
EnsemblBacteria	CAB12280
GeneID	939937
KEGG	bsu:BSU04730
PATRIC	18972530
GenoList	BSU04730
eggNOG	COG1191
HOGENOM	HOG000270270
InParanoid	P06574
KO	K03090
OMA	QCDEAQE
OrthoDB	EOG6TBHDX
PhylomeDB	P06574
BioCyc	BSUB:BSU04730-MONOMER
Proteomes	UP000001570
GO	GO:0003677 GO:0003700 GO:0016987 GO:0006352 GO:0043620
Gene3D	1.10.10.10
InterPro	IPR014284 IPR014288 IPR014322 IPR000943 IPR007627 IPR007624 IPR007630 IPR013325 IPR013324 IPR011991
Pfam	PF04542 PF04539 PF04545
PRINTS	PR00046
SUPFAM	SSF88659 SSF88946
TIGRFAMs	TIGR02980 TIGR02937 TIGR02941
PROSITE	PS00716

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0080134	regulation of response to stress	PMID:10383961	ECO:0000315			P		The authors used a null mutation of the sigma b factor to determine whether it would effect the survival of the bacteria under various conditions. A large drop in survival was found in bacteria with the null mutation under heat, ethanol, shock, salt, and acid stress.	complete CACAO 11558
	GO:0016987	sigma factor activity	PMID:8320211	ECO:0000315			F		The authors performed transformations on B. subtilis in order to inactivate the sigma B factor by introducing a null sigma B factor mutation. These bacteria had a socB1 frameshift mutation which inhibited a negative regulator of Sigma B factor, thus increasing the amount of sigma B factor produced in cells without the null mutation of sigma B factor, increasing the experiments sensitivity. They then monitored the gene expression of the bacteria by measuring the amount of b-galactosidase activity produced within them due to a lacz fusion with random genes on the B.subtilis genome. By locating the the fusion and measuring their activity, they found which genes were dependent to an extent on sigma B factor for activation by finding those with altered B-galactosidase activity.	complete CACAO 11559
involved_in	GO:0043620	regulation of DNA-templated transcription in response to stress	PMID:8012595	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000142	regulation of DNA-templated transcription, initiation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016987	P		Seeded From UniProt	complete
involved_in	GO:2000142	regulation of DNA-templated transcription, initiation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016987	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014322	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000943 InterPro:IPR007624 InterPro:IPR007627 InterPro:IPR007630 InterPro:IPR013325 InterPro:IPR014284 InterPro:IPR014322	F		Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000943 InterPro:IPR007624 InterPro:IPR007627 InterPro:IPR007630 InterPro:IPR013325 InterPro:IPR014284 InterPro:IPR014322	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000943 InterPro:IPR007624 InterPro:IPR007627 InterPro:IPR007630 InterPro:IPR013325 InterPro:IPR014284 InterPro:IPR014322	P		Seeded From UniProt	complete
enables	GO:0016987	sigma factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014288 InterPro:IPR014322	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
enables	GO:0016987	sigma factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0731	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0731	P		Seeded From UniProt	complete
	GO:0043620	regulation of DNA-dependent transcription in response to stress	PMID:8012595	ECO:0000315			P		The synthesis of stress proteins in the sigB mutant ML6 during heat shock was analysed by two-dimensional protein electrophoresis(Fig. 5).	complete CACAO 2655
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References

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