PSEAE:RPSH

Species (Taxon ID)	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). (208964)
Gene Name(s)	algU (synonyms: algT)
Protein Name(s)	RNA polymerase sigma-H factor Sigma-30
External Links
UniProt	Q06198
EMBL	U49151 L14760 L14761 L36379 AE004091 U17232
PIR	A49704
RefSeq	NP_249453.1 WP_003085543.1
ProteinModelPortal	Q06198
SMR	Q06198
STRING	208964.PA0762
PaxDb	Q06198
DNASU	882125
EnsemblBacteria	AAG04151
GeneID	882125
KEGG	pae:PA0762
PATRIC	19835798
PseudoCAP	PA0762
eggNOG	ENOG4105EMN COG1595
InParanoid	Q06198
KO	K03088
OMA	AEFYETG
PhylomeDB	Q06198
Proteomes	UP000002438
GO	GO:0000345 GO:0003677 GO:0016987 GO:0003700 GO:0042121 GO:0071236 GO:0036460 GO:0006352 GO:1902201 GO:0009405 GO:1900189 GO:1900036 GO:1902884 GO:1900233 GO:0032885
Gene3D	1.10.10.10
InterPro	IPR014284 IPR000838 IPR007627 IPR013249 IPR014286 IPR013325 IPR013324 IPR011991
Pfam	PF04542 PF08281
SUPFAM	SSF88659 SSF88946
TIGRFAMs	TIGR02939 TIGR02937
PROSITE	PS01063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:1900189	positive regulation of cell adhesion involved in single-species biofilm formation	PMID:20348252^[1]	ECO:0000315			P	Two rich media were compared for biofilm formation, LB broth and PPGAS, which is limited in phosphate and thereby promotes rhamnolipid production. P. aeruginosa PAOU mutant was constructed in which 546 bp of the 582-bp sequence of algU were deleted. The algU mutation did not affect the growth rate in liquid PPGAS at 37°C (data not shown)	complete CACAO 12449
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14645293^[2]	ECO:0005657	primer extension assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11807066^[3]	ECO:0005657	primer extension assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:14645293^[2]	ECO:0005667	site-directed mutagenesis evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0001216	DNA-binding transcription activator activity	PMID:14645293^[2]	ECO:0005667	site-directed mutagenesis evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:14645293^[2]	ECO:0005667	site-directed mutagenesis evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1902884	positive regulation of response to oxidative stress	PMID:7961422^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902201	negative regulation of bacterial-type flagellum-dependent cell motility	PMID:16291668^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900233	positive regulation of single-species biofilm formation on inanimate substrate	PMID:20348252^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900189	positive regulation of cell adhesion involved in single-species biofilm formation	PMID:20348252^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900036	positive regulation of cellular response to heat	PMID:9159526^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071236	cellular response to antibiotic	PMID:18838593^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036460	cellular response to cell envelope stress	PMID:19226327^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032885	regulation of polysaccharide biosynthetic process	PMID:7928961^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032885	regulation of polysaccharide biosynthetic process	PMID:14645293^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016987	sigma factor activity	PMID:7644517^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	PMID:8698507^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000345	cytosolic DNA-directed RNA polymerase complex	PMID:7644517^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000142	regulation of DNA-templated transcription, initiation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016987	P	Seeded From UniProt	complete
involved_in	GO:2000142	regulation of DNA-templated transcription, initiation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016987	P	Seeded From UniProt	complete
involved_in	GO:2000142	regulation of DNA-templated transcription, initiation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016987	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000838 InterPro:IPR013249 InterPro:IPR014286	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000838 InterPro:IPR007627 InterPro:IPR013249 InterPro:IPR013325 InterPro:IPR014284 InterPro:IPR014286	F	Seeded From UniProt	complete
involved_in	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000838 InterPro:IPR007627 InterPro:IPR013249 InterPro:IPR013325 InterPro:IPR014284 InterPro:IPR014286	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000838 InterPro:IPR007627 InterPro:IPR013249 InterPro:IPR013325 InterPro:IPR014284 InterPro:IPR014286	P	Seeded From UniProt	complete
enables	GO:0016987	sigma factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000838 InterPro:IPR013249 InterPro:IPR014286	F	Seeded From UniProt	complete
involved_in	GO:0042121	alginic acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0016	P	Seeded From UniProt	complete
enables	GO:0016987	sigma factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0731	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0731	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Bazire, A et al. (2010) The sigma factor AlgU plays a key role in formation of robust biofilms by nonmucoid Pseudomonas aeruginosa. J. Bacteriol. 192 3001-10 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wozniak, DJ et al. (2003) Control of Pseudomonas aeruginosa algZ expression by the alternative sigma factor AlgT. J. Bacteriol. 185 7297-300 PubMed GONUTS page
↑ Firoved, AM et al. (2002) Global genomic analysis of AlgU (sigma(E))-dependent promoters (sigmulon) in Pseudomonas aeruginosa and implications for inflammatory processes in cystic fibrosis. J. Bacteriol. 184 1057-64 PubMed GONUTS page
↑ Martin, DW et al. (1994) Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response. J. Bacteriol. 176 6688-96 PubMed GONUTS page
↑ Tart, AH et al. (2005) The alternative sigma factor AlgT represses Pseudomonas aeruginosa flagellum biosynthesis by inhibiting expression of fleQ. J. Bacteriol. 187 7955-62 PubMed GONUTS page
↑ Schurr, MJ & Deretic, V (1997) Microbial pathogenesis in cystic fibrosis: co-ordinate regulation of heat-shock response and conversion to mucoidy in Pseudomonas aeruginosa. Mol. Microbiol. 24 411-20 PubMed GONUTS page
↑ Fraud, S et al. (2008) MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor. Antimicrob. Agents Chemother. 52 4478-82 PubMed GONUTS page
↑ Wood, LF & Ohman, DE (2009) Use of cell wall stress to characterize sigma 22 (AlgT/U) activation by regulated proteolysis and its regulon in Pseudomonas aeruginosa. Mol. Microbiol. 72 183-201 PubMed GONUTS page
↑ Wozniak, DJ & Ohman, DE (1994) Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT. J. Bacteriol. 176 6007-14 PubMed GONUTS page
↑ ^10.0 ^10.1 Hershberger, CD et al. (1995) The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E). Proc. Natl. Acad. Sci. U.S.A. 92 7941-5 PubMed GONUTS page
↑ Yu, H et al. (1996) Virulence properties of Pseudomonas aeruginosa lacking the extreme-stress sigma factor AlgU (sigmaE). Infect. Immun. 64 2774-81 PubMed GONUTS page

[PMID:20348252-1] 1.0 ^1.1 ^1.2 Bazire, A et al. (2010) The sigma factor AlgU plays a key role in formation of robust biofilms by nonmucoid Pseudomonas aeruginosa. J. Bacteriol. 192 3001-10 PubMed GONUTS page

[PMID:14645293-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wozniak, DJ et al. (2003) Control of Pseudomonas aeruginosa algZ expression by the alternative sigma factor AlgT. J. Bacteriol. 185 7297-300 PubMed GONUTS page

[PMID:11807066-3] Firoved, AM et al. (2002) Global genomic analysis of AlgU (sigma(E))-dependent promoters (sigmulon) in Pseudomonas aeruginosa and implications for inflammatory processes in cystic fibrosis. J. Bacteriol. 184 1057-64 PubMed GONUTS page

[PMID:7961422-4] Martin, DW et al. (1994) Analysis of promoters controlled by the putative sigma factor AlgU regulating conversion to mucoidy in Pseudomonas aeruginosa: relationship to sigma E and stress response. J. Bacteriol. 176 6688-96 PubMed GONUTS page

[PMID:16291668-5] Tart, AH et al. (2005) The alternative sigma factor AlgT represses Pseudomonas aeruginosa flagellum biosynthesis by inhibiting expression of fleQ. J. Bacteriol. 187 7955-62 PubMed GONUTS page

[PMID:9159526-6] Schurr, MJ & Deretic, V (1997) Microbial pathogenesis in cystic fibrosis: co-ordinate regulation of heat-shock response and conversion to mucoidy in Pseudomonas aeruginosa. Mol. Microbiol. 24 411-20 PubMed GONUTS page

[PMID:18838593-7] Fraud, S et al. (2008) MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor. Antimicrob. Agents Chemother. 52 4478-82 PubMed GONUTS page

[PMID:19226327-8] Wood, LF & Ohman, DE (2009) Use of cell wall stress to characterize sigma 22 (AlgT/U) activation by regulated proteolysis and its regulon in Pseudomonas aeruginosa. Mol. Microbiol. 72 183-201 PubMed GONUTS page

[PMID:7928961-9] Wozniak, DJ & Ohman, DE (1994) Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT. J. Bacteriol. 176 6007-14 PubMed GONUTS page

[PMID:7644517-10] 10.0 ^10.1 Hershberger, CD et al. (1995) The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E). Proc. Natl. Acad. Sci. U.S.A. 92 7941-5 PubMed GONUTS page

[PMID:8698507-11] Yu, H et al. (1996) Virulence properties of Pseudomonas aeruginosa lacking the extreme-stress sigma factor AlgU (sigmaE). Infect. Immun. 64 2774-81 PubMed GONUTS page

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PSEAE:RPSH

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