Category:GO:0005085 ! guanyl-nucleotide exchange factor activity

name: guanyl-nucleotide exchange factor activity
namespace: molecular_function
alt_id: GO:0005086
alt_id: GO:0005087
alt_id: GO:0005088
alt_id: GO:0005089
alt_id: GO:0005090
alt_id: GO:0008321
alt_id: GO:0008433
alt_id: GO:0016219
alt_id: GO:0016220
alt_id: GO:0017034
alt_id: GO:0017112
alt_id: GO:0017132
alt_id: GO:0019839
alt_id: GO:0030676
def: "Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
subset: goslim_chembl
subset: goslim_drosophila
subset: goslim_yeast
synonym: "ARF guanyl-nucleotide exchange factor activity" NARROW []
synonym: "cAMP-dependent guanyl-nucleotide exchange factor activity" NARROW []
synonym: "GDP-dissociation stimulator activity" EXACT []
synonym: "GDS" EXACT []
synonym: "GEF" EXACT []
synonym: "GNRP" NARROW []
synonym: "guanyl-nucleotide release factor activity" EXACT []
synonym: "guanyl-nucleotide releasing factor" EXACT []
synonym: "Rab guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Rac guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Ral guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Ran guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Rap guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Ras guanyl-nucleotide exchange factor activity" NARROW []
synonym: "Rho guanine nucleotide exchange factor" EXACT []
synonym: "Rho guanyl-nucleotide exchange factor activity" NARROW []
synonym: "RhoGEF" EXACT []
synonym: "Sar guanyl-nucleotide exchange factor activity" NARROW []
is_a: GO:0030695 ! GTPase regulator activity
relationship: negatively_regulates: GO:0019003 ! GDP binding
relationship: positively_regulates: GO:0005525 ! GTP binding

AmiGO <GOterm>GO:0005085</GOterm>
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