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MOUSE:ABR

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Abr
Protein Name(s) Active breakpoint cluster region-related protein
External Links
UniProt Q5SSL4
EMBL AK134993
AK142364
AK153615
AL591143
AL663050
AL591143
AL663050
AL591143
AL663050
AL591143
AL663050
AL591143
AL663050
AL591143
AL663050
AL591143
AL663050
AL591143
AL663050
AL591143
BC056385
BC058708
BC059064
CCDS CCDS25066.1
CCDS36231.1
CCDS70246.1
RefSeq NP_001278115.1
NP_932135.1
NP_942597.1
NP_942598.1
XP_006532045.1
UniGene Mm.258939
ProteinModelPortal Q5SSL4
SMR Q5SSL4
BioGrid 225161
IntAct Q5SSL4
PhosphoSite Q5SSL4
MaxQB Q5SSL4
PaxDb Q5SSL4
PRIDE Q5SSL4
Ensembl ENSMUST00000065028
ENSMUST00000072740
ENSMUST00000094012
ENSMUST00000108408
GeneID 109934
KEGG mmu:109934
UCSC uc007kfr.1
uc007kfs.1
uc007kft.1
uc007kfv.1
CTD 29
MGI MGI:107771
eggNOG NOG267747
GeneTree ENSGT00760000119098
HOVERGEN HBG004165
InParanoid Q5SSL4
OMA WPFLFLV
OrthoDB EOG7BP81P
PhylomeDB Q5SSL4
TreeFam TF105082
Reactome REACT_204733
REACT_209641
REACT_210090
ChiTaRS Abr
NextBio 363025
PRO PR:Q5SSL4
Proteomes UP000000589
Bgee Q5SSL4
ExpressionAtlas Q5SSL4
Genevestigator Q5SSL4
GO GO:0005829
GO:0005886
GO:0005096
GO:0030675
GO:0005089
GO:0030036
GO:0007420
GO:0042472
GO:0035556
GO:0030336
GO:0050728
GO:0043314
GO:0050885
GO:0043547
GO:0050766
GO:0032855
GO:0032496
Gene3D 1.10.555.10
1.20.900.10
2.30.29.30
2.60.40.150
InterPro IPR000008
IPR000219
IPR001331
IPR001849
IPR011993
IPR008936
IPR000198
Pfam PF00168
PF00169
PF00620
PF00621
SMART SM00239
SM00233
SM00324
SM00325
SUPFAM SSF48065
SSF48350
SSF49562
PROSITE PS50004
PS00741
PS50010
PS50003
PS50238

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0060313

negative regulation of blood vessel remodeling

PMID:23152932[1]

ECO:0000315

P

Figure 2A shows that the walls of the pulmonary arteries of the abr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that abr is one component needed for the prevention of artery remodeling

complete
CACAO 6053

GO:0043114

regulation of vascular permeability

PMID:23152932[1]

ECO:0000315

P

"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Abr...were clearly more severely affected." This suggests that abr is a component needed for the prevention of vascular leakage under hypoxic conditions.

complete
CACAO 6055

GO:0002692

negative regulation of cellular extravasation

PMID:23152932[1]

ECO:0000315

P

Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking Abr...function as compared to wt mice," suggesting that abr prevents leukocytes from pulmonary extravasation.

complete
CACAO 6068

involved_in

GO:0002692

negative regulation of cellular extravasation

PMID:23152932[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043114

regulation of vascular permeability

PMID:23152932[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060313

negative regulation of blood vessel remodeling

PMID:23152932[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

PMID:20962234[2]

ECO:0001225

knockout evidence used in manual assertion

C

part_of:(UBERON:0002421)

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

PMID:20962234[2]

ECO:0001225

knockout evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:20962234[2]

ECO:0001225

knockout evidence used in manual assertion

P

  • occurs_in:(GO:0098978)
  • occurs_in:(UBERON:0000061)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:20962234[2]

ECO:0001225

knockout evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0099092

postsynaptic density, intracellular component

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306279

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1306279

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050885

neuromuscular process controlling balance

PMID:11921339[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050766

positive regulation of phagocytosis

PMID:17116687[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

  • regulates_o_occurs_in:(EMAPA:32760)
  • regulates_o_occurs_in:(CL:0000235)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050728

negative regulation of inflammatory response

PMID:19703997[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388713

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043314

negative regulation of neutrophil degranulation

PMID:19703997[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

regulates_o_occurs_in:(CL:0000775)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042472

inner ear morphogenesis

PMID:11921339[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

has_participant:(EMAPA:17293)|has_participant:(EMAPA:17290)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032496

response to lipopolysaccharide

PMID:19703997[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2388713

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030336

negative regulation of cell migration

PMID:17116687[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

  • regulates_o_occurs_in:(EMAPA:32760)
  • regulates_o_results_in_movement_of:(CL:0000235)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030036

actin cytoskeleton organization

PMID:17116687[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

  • occurs_in:(CL:0000581)|occurs_in:(EMAPA:32760)
  • occurs_in:(CL:0000235)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007420

brain development

PMID:11684658[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17116687[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32760)
  • part_of:(CL:0000235)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:17116687[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32760)
  • part_of:(CL:0000235)

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:19703997[5]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88141

F

occurs_in:(CL:0000775)

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:17116687[4]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(MGI:MGI:97846)|has_regulation_target:(MGI:MGI:2180784)

Seeded From UniProt

complete

part_of

GO:0099092

postsynaptic density, intracellular component

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2JTR4
ensembl:ENSRNOP00000068811

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2JTR4
ensembl:ENSRNOP00000068811

C

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001331

F

Seeded From UniProt

complete

enables

GO:0005089

Rho guanyl-nucleotide exchange factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000219

F

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037769

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000198
InterPro:IPR008936

P

Seeded From UniProt

complete

involved_in

GO:0035023

regulation of Rho protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000219

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001331

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037769

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:11684658[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0344

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Yu, M et al. (2012) Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS ONE 7 e49756 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Oh, D et al. (2010) Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J. Neurosci. 30 14134-44 PubMed GONUTS page
  3. ↑ 3.0 3.1 Kaartinen, V et al. (2002) Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev. Dyn. 223 517-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Cho, YJ et al. (2007) Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol. Cell. Biol. 27 899-911 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Cunnick, JM et al. (2009) Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol. Cell. Biol. 29 5742-50 PubMed GONUTS page
  6. ↑ 6.0 6.1 Kaartinen, V et al. (2001) Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development 128 4217-27 PubMed GONUTS page
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