PMID:23152932

Citation	Yu, M, Gong, D, Lim, M, Arutyunyan, A, Groffen, J and Heisterkamp, N (2012) Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS ONE 7:e49756
Abstract	Bcr and Abr are GTPase activating proteins that specifically downregulate activity of the small GTPase Rac in restricted cell types in vivo. Rac1 is expressed in smooth muscle cells, a critical cell type involved in the pathogenesis of pulmonary hypertension. The molecular mechanisms that underlie hypoxia-associated pulmonary hypertension are not well-defined.
Links	PubMed Online version:10.1371/journal.pone.0049756
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:BCR	involved_in	GO:0060313: negative regulation of blood vessel remodeling	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:BCR	involved_in	GO:0002692: negative regulation of cellular extravasation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:BCR		GO:0060313: negative regulation of blood vessel remodeling	ECO:0000315:		P		Figure 2A shows that the walls of the pulmonary arteries of the bcr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that bcr is one component needed for the prevention of artery remodeling	complete CACAO 6049
MOUSE:BCR		GO:0043114: regulation of vascular permeability	ECO:0000315:		P		"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Bcr...were clearly more severely affected." This suggests that bcr is a component needed for the prevention of vascular leakage under hypoxic conditions.	complete CACAO 6056
MOUSE:BCR		GO:0002692: negative regulation of cellular extravasation	ECO:0000315:		P		Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking... Bcr function as compared to wt mice," suggesting that bcr prevents leukocytes from pulmonary extravasation.	complete CACAO 6069
MOUSE:BCR	involved_in	GO:0043114: regulation of vascular permeability	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:ABR		GO:0060313: negative regulation of blood vessel remodeling	ECO:0000315:		P		Figure 2A shows that the walls of the pulmonary arteries of the abr-/- mice are remarkably thicker than those of the wt mice after hypoxia, suggesting that abr is one component needed for the prevention of artery remodeling	complete CACAO 6053
MOUSE:ABR		GO:0043114: regulation of vascular permeability	ECO:0000315:		P		"Figure 3C shows that chronic hypoxia promoted loss of endothelial barrier function and, moreover, mice lacking Abr...were clearly more severely affected." This suggests that abr is a component needed for the prevention of vascular leakage under hypoxic conditions.	complete CACAO 6055
MOUSE:ABR		GO:0002692: negative regulation of cellular extravasation	ECO:0000315:		P		Figure 3A shows that "pulmonary extravasation of leukocytes under hypoxia was significantly increased in the mice lacking Abr...function as compared to wt mice," suggesting that abr prevents leukocytes from pulmonary extravasation.	complete CACAO 6068
MOUSE:ABR	involved_in	GO:0060313: negative regulation of blood vessel remodeling	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:ABR	involved_in	GO:0043114: regulation of vascular permeability	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:ABR	involved_in	GO:0002692: negative regulation of cellular extravasation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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