HUMAN:VAV3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	VAV3
Protein Name(s)	Guanine nucleotide exchange factor VAV3 VAV-3
External Links
UniProt	Q9UKW4
EMBL	AF035442 AF067817 AF118887 AF118886 AK304088 AK316295 AL391235 AC114491 AL353892 AL513206 AL591042 AL513206 AC114491 AL353892 AL391235 AL591042 AL513206 AC114491 AL591042 AL591042 AC114491 AL353892 AL391235 AL513206 AL591042 AC114491 AL513206 AL353892 AC114491 AL391235 AL513206 AL591042 CH471156 BC143969
CCDS	CCDS44181.1 CCDS785.1
RefSeq	NP_001073343.1 NP_006104.4 XP_005270417.1
UniGene	Hs.267659
PDB	2D86
PDBsum	2D86
ProteinModelPortal	Q9UKW4
SMR	Q9UKW4
BioGrid	115715
IntAct	Q9UKW4
MINT	MINT-256977
STRING	9606.ENSP00000359073
PhosphoSite	Q9UKW4
BioMuta	VAV3
DMDM	12643372
MaxQB	Q9UKW4
PaxDb	Q9UKW4
PRIDE	Q9UKW4
DNASU	10451
Ensembl	ENST00000370056 ENST00000415432 ENST00000527011
GeneID	10451
KEGG	hsa:10451
UCSC	uc001dvj.1 uc001dvk.1 uc010ouw.1
CTD	10451
GeneCards	GC01M107571
HGNC	HGNC:12659
HPA	CAB002012 HPA028138
MIM	605541
neXtProt	NX_Q9UKW4
PharmGKB	PA37282
eggNOG	NOG326494
GeneTree	ENSGT00800000124085
HOGENOM	HOG000234364
HOVERGEN	HBG018066
InParanoid	Q9UKW4
KO	K05730
OMA	GPPLHIQ
OrthoDB	EOG73FQKZ
PhylomeDB	Q9UKW4
TreeFam	TF316171
Reactome	R-HSA-114604 R-HSA-193648 R-HSA-194840 R-HSA-2029482 R-HSA-2424491 R-HSA-2871796 R-HSA-2871809 R-HSA-3928665 R-HSA-416482 R-HSA-4420097 R-HSA-5218920
SignaLink	Q9UKW4
ChiTaRS	VAV3
EvolutionaryTrace	Q9UKW4
GeneWiki	VAV3
GenomeRNAi	10451
NextBio	39617
PRO	PR:Q9UKW4
Proteomes	UP000005640
Bgee	Q9UKW4
CleanEx	HS_VAV3
ExpressionAtlas	Q9UKW4
Genevisible	Q9UKW4
GO	GO:0005829 GO:0070062 GO:0005886 GO:0005096 GO:0005085 GO:0046872 GO:0030676 GO:0005070 GO:0001525 GO:0097190 GO:0007411 GO:0050853 GO:0007596 GO:0006974 GO:0048013 GO:0038095 GO:0038096 GO:0045087 GO:0007229 GO:0030032 GO:0048011 GO:0030593 GO:0030168 GO:0043065 GO:0030890 GO:0045785 GO:0043547 GO:0043552 GO:0009967 GO:0008361 GO:0043087 GO:0035023 GO:0051056 GO:0042493 GO:0007264 GO:0048010 GO:0006906
Gene3D	1.10.418.10 1.20.900.10 2.30.29.30 3.30.505.10
InterPro	IPR022613 IPR001715 IPR000219 IPR001331 IPR002219 IPR011993 IPR001849 IPR000980 IPR011511 IPR001452 IPR003096 IPR028530
PANTHER	PTHR22826:SF97
Pfam	PF00130 PF11971 PF00169 PF00621 PF00017 PF07653
PRINTS	PR00401 PR00452 PR00888
SMART	SM00109 SM00033 SM00233 SM00325 SM00252 SM00326
SUPFAM	SSF47576 SSF48065 SSF50044 SSF55550
PROSITE	PS50021 PS00741 PS50010 PS50003 PS50001 PS50002 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0008361	regulation of cell size	PMID:22467863^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P15498,UniProtKB:P35241,UniProtKB:P52735	P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	PMID:22467863^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P15498,UniProtKB:P35241,UniProtKB:P52735	P	has_regulation_target:(UniProtKB:P63000)	Seeded From UniProt	complete
NOT\|involved_in	GO:0008361	regulation of cell size	PMID:22467863^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P15498,UniProtKB:P52735	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:17875758^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17875758^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:17875758^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17875758^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	PMID:8990121^[3]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005070	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
enables	GO:0030676	Rac guanyl-nucleotide exchange factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	F		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
involved_in	GO:0006906	vesicle fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	C		Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	F		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R0C8 ensembl:ENSMUSP00000036270	F		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	F		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001331 InterPro:IPR002219	P		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	PMID:10523675^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:10523675^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005070	SH3/SH2 adaptor activity	PMID:10523675^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051056	regulation of small GTPase mediated signal transduction	Reactome:R-HSA-194840	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-193648	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8951586 Reactome:R-HSA-5357483 Reactome:R-HSA-5357472 Reactome:R-HSA-5357445 Reactome:R-HSA-5218850 Reactome:R-HSA-5218820 Reactome:R-HSA-442314 Reactome:R-HSA-430158 Reactome:R-HSA-419166 Reactome:R-HSA-3928628 Reactome:R-HSA-3928607 Reactome:R-HSA-3928604 Reactome:R-HSA-2730892 Reactome:R-HSA-2730889 Reactome:R-HSA-2730858 Reactome:R-HSA-2730856 Reactome:R-HSA-2730847 Reactome:R-HSA-2730841 Reactome:R-HSA-2730840 Reactome:R-HSA-2730833 Reactome:R-HSA-2424487 Reactome:R-HSA-2424486 Reactome:R-HSA-2424485 Reactome:R-HSA-2424484 Reactome:R-HSA-2424481 Reactome:R-HSA-2424476 Reactome:R-HSA-205039 Reactome:R-HSA-2029458 Reactome:R-HSA-2029453 Reactome:R-HSA-2029451 Reactome:R-HSA-194913	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	Reactome:R-HSA-442314 Reactome:R-HSA-2730840 Reactome:R-HSA-2424476	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F		Seeded From UniProt	complete
	GO:0001772	immunological synapse	PMID:15708849^[5]	ECO:0000314			C		Figure 1F. shows, using digital fluorescence microscopy, that Vav3 translocates to the plasma membrane and localizes to the immunological synapse upon T cell activation.	complete CACAO 11020
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Valderrama, F et al. (2012) Radixin regulates cell migration and cell-cell adhesion through Rac1. J. Cell. Sci. 125 3310-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page
↑ Crespo, P et al. (1997) Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385 169-72 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Movilla, N & Bustelo, XR (1999) Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol. Cell. Biol. 19 7870-85 PubMed GONUTS page
↑ Charvet, C et al. (2005) Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. J. Biol. Chem. 280 15289-99 PubMed GONUTS page

[PMID:22467863-1] 1.0 ^1.1 ^1.2 Valderrama, F et al. (2012) Radixin regulates cell migration and cell-cell adhesion through Rac1. J. Cell. Sci. 125 3310-9 PubMed GONUTS page

[PMID:17875758-2] 2.0 ^2.1 ^2.2 ^2.3 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page

[PMID:8990121-3] Crespo, P et al. (1997) Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385 169-72 PubMed GONUTS page

[PMID:10523675-4] 4.0 ^4.1 ^4.2 Movilla, N & Bustelo, XR (1999) Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Mol. Cell. Biol. 19 7870-85 PubMed GONUTS page

[PMID:15708849-5] Charvet, C et al. (2005) Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. J. Biol. Chem. 280 15289-99 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

HUMAN:VAV3

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools