HUMAN:HBXIP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HBXIP (synonyms: XIP)
Protein Name(s)	Hepatitis B virus X-interacting protein HBV X-interacting protein HBX-interacting protein
External Links
UniProt	O43504
EMBL	AF029890 AY623819 CR456866 CR542130 AL390797 BC062619
IPI	IPI00935729
RefSeq	NP_006393.2
UniGene	Hs.439815
PDB	3MS6 3MSH
PDBsum	3MS6 3MSH
ProteinModelPortal	O43504
SMR	O43504
IntAct	O43504
MINT	MINT-1389550
STRING	O43504
PhosphoSite	O43504
PRIDE	O43504
DNASU	10542
Ensembl	ENST00000256644 ENST00000369775
GeneID	10542
KEGG	hsa:10542
UCSC	uc001dzr.3
CTD	10542
GeneCards	GC01M110943
H-InvDB	HIX0029151
HGNC	HGNC:17955
HPA	HPA006812
MIM	608521
neXtProt	NX_O43504
PharmGKB	PA29211
eggNOG	NOG84672
GeneTree	ENSGT00390000006247
HOVERGEN	HBG010343
InParanoid	O43504
OrthoDB	EOG4NKBWP
EvolutionaryTrace	O43504
NextBio	39997
ArrayExpress	O43504
Bgee	O43504
CleanEx	HS_HBXIP
Genevestigator	O43504
GermOnline	ENSG00000134248
GO	GO:0005829 GO:0005515 GO:0006916 GO:0043154 GO:0009615 GO:0019079
InterPro	IPR024135
PANTHER	PTHR13342

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0071986	Ragulator complex	PMID:22980980^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:22980980^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061462	protein localization to lysosome	PMID:22980980^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12773388^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12773388^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0060090	molecular adaptor activity	PMID:22980980^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:22980980^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008361	regulation of cell size	PMID:22980980^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12773388^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:22980980^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
contributes_to	GO:0005085	guanyl-nucleotide exchange factor activity	PMID:22980980^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904263	positive regulation of TORC1 signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026090 PANTHER:PTN001410778	P	Seeded From UniProt	complete
part_of	GO:0071986	Ragulator complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001410778 UniProtKB:O43504	C	Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026090 PANTHER:PTN001410778 UniProtKB:O43504	P	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001410778 UniProtKB:O43504	C	Seeded From UniProt	complete
contributes_to	GO:0005085	guanyl-nucleotide exchange factor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001410778 UniProtKB:O43504	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024135	C	Seeded From UniProt	complete
involved_in	GO:0019079	viral genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024135	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024135	P	Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024135	P	Seeded From UniProt	complete
part_of	GO:0071986	Ragulator complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024135	C	Seeded From UniProt	complete
involved_in	GO:0019079	viral genome replication	PMID:9499022^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:9499022^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	Reactome:R-HSA-5675790 Reactome:R-HSA-5672817 Reactome:R-HSA-5672017 Reactome:R-HSA-5672010	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	Reactome:R-HSA-380972	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	Reactome:R-HSA-8952726 Reactome:R-HSA-8952716 Reactome:R-HSA-8944454 Reactome:R-HSA-5675790 Reactome:R-HSA-5673768 Reactome:R-HSA-5672843 Reactome:R-HSA-5672828 Reactome:R-HSA-5672824 Reactome:R-HSA-5672817 Reactome:R-HSA-5672017 Reactome:R-HSA-5672010 Reactome:R-HSA-5653974 Reactome:R-HSA-5653968 Reactome:R-HSA-5653936 Reactome:R-HSA-447074 Reactome:R-HSA-380979 Reactome:R-HSA-377186 Reactome:R-HSA-165718 Reactome:R-HSA-165692 Reactome:R-HSA-165680	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Bar-Peled, L et al. (2012) Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150 1196-208 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Marusawa, H et al. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 22 2729-40 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Melegari, M et al. (1998) Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J. Virol. 72 1737-43 PubMed GONUTS page

[PMID:22980980-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Bar-Peled, L et al. (2012) Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150 1196-208 PubMed GONUTS page

[PMID:12773388-2] 2.0 ^2.1 ^2.2 Marusawa, H et al. (2003) HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J. 22 2729-40 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9499022-4] 4.0 ^4.1 Melegari, M et al. (1998) Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J. Virol. 72 1737-43 PubMed GONUTS page

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HUMAN:HBXIP

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