HUMAN:RGRF2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RASGRF2 (synonyms: GRF2)
Protein Name(s)	Ras-specific guanine nucleotide-releasing factor 2 Ras-GRF2 Ras guanine nucleotide exchange factor 2
External Links
UniProt	O14827
EMBL	AF023130 AF181250 CH471084 BC126112 BC136296
CCDS	CCDS4052.1
RefSeq	NP_008840.1
UniGene	Hs.162129
ProteinModelPortal	O14827
SMR	O14827
BioGrid	111859
IntAct	O14827
STRING	9606.ENSP00000265080
PhosphoSite	O14827
PaxDb	O14827
PRIDE	O14827
Ensembl	ENST00000265080
GeneID	5924
KEGG	hsa:5924
UCSC	uc003kha.2
CTD	5924
GeneCards	GC05P080292
HGNC	HGNC:9876
HPA	HPA018679
MIM	606614
neXtProt	NX_O14827
PharmGKB	PA34239
eggNOG	NOG288712
GeneTree	ENSGT00770000120448
HOGENOM	HOG000046000
HOVERGEN	HBG005208
InParanoid	O14827
KO	K12326
OMA	CSCERTP
OrthoDB	EOG7H1JKP
PhylomeDB	O14827
TreeFam	TF317296
Reactome	REACT_11051 REACT_13638 REACT_18407 REACT_20546
ChiTaRS	RASGRF2
GeneWiki	RASGRF2
GenomeRNAi	5924
NextBio	23072
PRO	PR:O14827
Proteomes	UP000005640
Bgee	O14827
CleanEx	HS_RASGRF2
ExpressionAtlas	O14827
Genevestigator	O14827
GO	GO:0005829 GO:0005789 GO:0005886 GO:0005089 GO:0097190 GO:0048011 GO:0043065 GO:2000310 GO:0051056 GO:0007264 GO:0007268
Gene3D	1.10.840.10 1.20.900.10 2.30.29.30
InterPro	IPR000219 IPR000048 IPR001849 IPR011993 IPR000651 IPR019804 IPR023578 IPR001895
Pfam	PF00169 PF00617 PF00618 PF00621
SMART	SM00015 SM00233 SM00147 SM00229 SM00325
SUPFAM	SSF48065 SSF48366
PROSITE	PS50010 PS50096 PS50003 PS00720 PS50009 PS50212

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0034976	response to endoplasmic reticulum stress		ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000071)	Seeded From UniProt	complete
enables	GO:0005088	Ras guanyl-nucleotide exchange factor activity		ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000071) part_of:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001895 InterPro:IPR008937 InterPro:IPR019804 InterPro:IPR030744 InterPro:IPR036964	F		Seeded From UniProt	complete
enables	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219	F		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001895 InterPro:IPR008937 InterPro:IPR019804 InterPro:IPR036964	P		Seeded From UniProt	complete
involved_in	GO:0035023	regulation of Rho protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000219 InterPro:IPR030744	P		Seeded From UniProt	complete
involved_in	GO:0046578	regulation of Ras protein signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030744	P		Seeded From UniProt	complete
involved_in	GO:0051056	regulation of small GTPase mediated signal transduction	Reactome:R-HSA-194840	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-193648	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5672965	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5672965 Reactome:R-HSA-419166 Reactome:R-HSA-205039 Reactome:R-HSA-194913	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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References

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