YEAST:SEC2

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	SEC2
Protein Name(s)	Rab guanine nucleotide exchange factor SEC2 GDP-GTP exchange factor SEC2
External Links
UniProt	P17065
EMBL	X52147 Z71548 BK006947
PIR	A35597
RefSeq	NP_014127.1
PDB	2E7S 2EQB 2OCY 4ZDW
PDBsum	2E7S 2EQB 2OCY 4ZDW
ProteinModelPortal	P17065
SMR	P17065
BioGrid	35568
DIP	DIP-2493N
IntAct	P17065
MINT	MINT-438606
iPTMnet	P17065
MaxQB	P17065
PRIDE	P17065
EnsemblFungi	YNL272C
GeneID	855449
KEGG	sce:YNL272C
EuPathDB	FungiDB:YNL272C
SGD	S000005216
HOGENOM	HOG000057109
InParanoid	P17065
KO	K19940
OMA	TCEIFAF
OrthoDB	EOG0937091Q
BioCyc	YEAST:G3O-33266-MONOMER
EvolutionaryTrace	P17065
PRO	PR:P17065
Proteomes	UP000002311
GO	GO:0005935 GO:0005934 GO:0005829 GO:0030133 GO:0005085 GO:0070273 GO:0006914 GO:0006887 GO:0015031
InterPro	IPR009449
Pfam	PF06428

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005935	cellular bud neck	PMID:26928762^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043332	mating projection tip	PMID:19053807^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0070273	phosphatidylinositol-4-phosphate binding	PMID:20493815^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070273	phosphatidylinositol-4-phosphate binding	PMID:20493815^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	PMID:12045183^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:20444978^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000001889	P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:20444978^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	PMID:12045183^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	PMID:20493815^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005934	cellular bud tip	PMID:20493815^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12045183^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	PMID:9199166^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17292842^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17065	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11087867^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17065	F	Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040351	F	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
enables	GO:0005085	guanyl-nucleotide exchange factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0344	F	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0244	C	Seeded From UniProt	complete
part_of	GO:0005934	cellular bud tip	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0030	C	Seeded From UniProt	complete
part_of	GO:0005935	cellular bud neck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0029	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page
↑ Narayanaswamy, R et al. (2009) Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J. Proteome Res. 8 6-19 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Mizuno-Yamasaki, E et al. (2010) Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev. Cell 18 828-40 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Ortiz, D et al. (2002) Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J. Cell Biol. 157 1005-15 PubMed GONUTS page
↑ ^5.0 ^5.1 Geng, J et al. (2010) Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol. Biol. Cell 21 2257-69 PubMed GONUTS page
↑ Walch-Solimena, C et al. (1997) Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J. Cell Biol. 137 1495-509 PubMed GONUTS page
↑ Sato, Y et al. (2007) Asymmetric coiled-coil structure with Guanine nucleotide exchange activity. Structure 15 245-52 PubMed GONUTS page
↑ Newman, JR et al. (2000) A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 97 13203-8 PubMed GONUTS page

[PMID:26928762-1] Yofe, I et al. (2016) One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy. Nat. Methods 13 371-378 PubMed GONUTS page

[PMID:19053807-2] Narayanaswamy, R et al. (2009) Systematic definition of protein constituents along the major polarization axis reveals an adaptive reuse of the polarization machinery in pheromone-treated budding yeast. J. Proteome Res. 8 6-19 PubMed GONUTS page

[PMID:20493815-3] 3.0 ^3.1 ^3.2 ^3.3 Mizuno-Yamasaki, E et al. (2010) Phosphatidylinositol 4-phosphate controls both membrane recruitment and a regulatory switch of the Rab GEF Sec2p. Dev. Cell 18 828-40 PubMed GONUTS page

[PMID:12045183-4] 4.0 ^4.1 ^4.2 Ortiz, D et al. (2002) Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J. Cell Biol. 157 1005-15 PubMed GONUTS page

[PMID:20444978-5] 5.0 ^5.1 Geng, J et al. (2010) Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol. Biol. Cell 21 2257-69 PubMed GONUTS page

[PMID:9199166-6] Walch-Solimena, C et al. (1997) Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J. Cell Biol. 137 1495-509 PubMed GONUTS page

[PMID:17292842-7] Sato, Y et al. (2007) Asymmetric coiled-coil structure with Guanine nucleotide exchange activity. Structure 15 245-52 PubMed GONUTS page

[PMID:11087867-8] Newman, JR et al. (2000) A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 97 13203-8 PubMed GONUTS page

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YEAST:SEC2

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