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HUMAN:HERC2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HERC2 (ECO:0000312 with EMBL:AAD08657.1)
Protein Name(s) E3 ubiquitin-protein ligase HERC2

HECT domain and RCC1-like domain-containing protein 2

External Links
UniProt O95714
EMBL AF071172
AC091304
AC126332
AC135329
AF224243
AF224242
AF224245
AF224244
AF224249
AF224246
AF224247
AF224248
AF224251
AF224250
AF224255
AF224254
AF224252
AF224253
AF224257
AF224256
AF225401
AF225400
AF225404
AF225402
AF225403
AF225407
AF225405
AF225406
AF225409
AF225408
CCDS CCDS10021.1
RefSeq NP_004658.3
UniGene Hs.434890
Hs.610412
Hs.741019
PDB 2KEO
3KCI
4L1M
PDBsum 2KEO
3KCI
4L1M
ProteinModelPortal O95714
SMR O95714
BioGrid 114438
DIP DIP-37632N
IntAct O95714
MINT MINT-8415335
PhosphoSite O95714
MaxQB O95714
PaxDb O95714
PRIDE O95714
Ensembl ENST00000261609
GeneID 8924
KEGG hsa:8924
UCSC uc001zbj.4
CTD 8924
GeneCards GC15M028356
GeneReviews HERC2
H-InvDB HIX0012044
HIX0017540
HIX0038121
HIX0038320
HIX0038830
HIX0173226
HIX0173299
HIX0194348
HGNC HGNC:4868
HPA CAB017188
HPA048389
MIM 227220
605837
615516
neXtProt NX_O95714
Orphanet 329195
PharmGKB PA29243
eggNOG COG5021
GeneTree ENSGT00770000120501
HOVERGEN HBG081598
InParanoid O95714
KO K10595
OMA GHGTDVH
PhylomeDB O95714
TreeFam TF320636
Reactome REACT_75842
UniPathway UPA00143
ChiTaRS HERC2
EvolutionaryTrace O95714
GeneWiki HERC2
GenomeRNAi 8924
NextBio 33552
PRO PR:O95714
Proteomes UP000005640
Bgee O95714
ExpressionAtlas O95714
Genevestigator O95714
GO GO:0005814
GO:0005737
GO:0016020
GO:0005743
GO:0005634
GO:0005085
GO:0020037
GO:0016874
GO:0032183
GO:0031625
GO:0004842
GO:0008270
GO:0006974
GO:0006281
GO:0006886
GO:0043547
GO:0016567
GO:0042787
GO:0007283
Gene3D 2.130.10.30
2.30.30.30
2.60.120.260
3.10.120.10
InterPro IPR004939
IPR006624
IPR021097
IPR001199
IPR008979
IPR000569
IPR010606
IPR009091
IPR000408
IPR014722
IPR000433
Pfam PF03256
PF11515
PF00173
PF00632
PF06701
PF00415
PF00569
PRINTS PR00633
SMART SM00119
SM00706
SM00291
SUPFAM SSF49785
SSF50985
SSF55856
SSF56204
PROSITE PS50255
PS51284
PS50237
PS51416
PS00626
PS50012
PS01357
PS50135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016020

membrane

PMID:19946888[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0032183

SUMO binding

PMID:22508508[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031625

ubiquitin protein ligase binding

PMID:22508508[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O76064

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

PMID:20304803[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:22508508[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:9949213[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20304803[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20304803[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005085

guanyl-nucleotide exchange factor activity

PMID:9949213[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

PMID:20304803[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103234
PANTHER:PTN000134460

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000882682
UniProtKB:O95714

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000882682
UniProtKB:O95714

C

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4U2R1
ensembl:ENSMUSP00000131573

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q4U2R1
ensembl:ENSMUSP00000131573

P

Seeded From UniProt

complete

enables

GO:0004842

ubiquitin-protein transferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000569
InterPro:IPR010606
InterPro:IPR035983
InterPro:IPR037252

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000433

F

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010606
InterPro:IPR037252

F

Seeded From UniProt

complete

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

Reactome:R-HSA-5693571

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-69891
Reactome:R-HSA-5693599
Reactome:R-HSA-5693566
Reactome:R-HSA-5693551
Reactome:R-HSA-5686900
Reactome:R-HSA-5686704
Reactome:R-HSA-5686685
Reactome:R-HSA-5684071
Reactome:R-HSA-5684052
Reactome:R-HSA-5683801
Reactome:R-HSA-5683735
Reactome:R-HSA-5683425
Reactome:R-HSA-5683405
Reactome:R-HSA-5683385
Reactome:R-HSA-5683384
Reactome:R-HSA-5683077
Reactome:R-HSA-5682863
Reactome:R-HSA-5682858
Reactome:R-HSA-5682629
Reactome:R-HSA-5682607
Reactome:R-HSA-5682598
Reactome:R-HSA-5682586
Reactome:R-HSA-4551724

ECO:0000304

author statement supported by traceable reference used in manual assertion























C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Danielsen, JR et al. (2012) DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. J. Cell Biol. 197 179-87 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Kang, TH et al. (2010) Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc. Natl. Acad. Sci. U.S.A. 107 4890-5 PubMed GONUTS page
  4. ↑ 4.0 4.1 Ji, Y et al. (1999) The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities. Hum. Mol. Genet. 8 533-42 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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